Compare Allegra D vs. Advil Allergy and Congestion Relief

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Allegra D
(Pseudoephedrine / Fexofenadine)

Advil Allergy And Congestion Relief
(Chlorpheniramine / Ibuprofen / Phenylephrine)

Treats allergy symptoms and congestion. Allegra D (Pseudoephedrine / Fexofenadine) is a combination allergy medicine that's useful if you have congestion and runny nose.Relieves cold and allergy symptoms. Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) is an okay combination medicine to relieve pain and congestion. The antihistamine can make you sleepy and the decongestant can keep you awake, so it could affect you either way.
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Reviews & ratings
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Reviews for Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine)
73%
+6% vs. Allegra D (Pseudoephedrine / Fexofenadine)
30%
37% vs. Allegra D (Pseudoephedrine / Fexofenadine)
6%
6% vs. Allegra D (Pseudoephedrine / Fexofenadine)
Side effects
Allegra DAdvil Allergy and Congestion Relief
  • Back pain 2%
More Allegra D side effects »

We haven’t found good data for Advil Allergy and Congestion Relief side effects.

FDA side effect reports for Advil Allergy and Congestion Relief »
How it works
Allegra DAdvil Allergy and Congestion Relief
Allegra D (Pseudoephedrine / Fexofenadine) is a combination medicine that relieves allergy symptoms. Fexofenadine (an antihistamine) prevents allergy symptoms like runny nose, sneezing, and itching. Pseudoephedrine (a decongestant) clears your sinuses.Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) is a combination medicine that treats cold and allergy symptoms. Ibuprofen is an NSAID that relieves swelling, pain, and fever. Chlorpheniramine is an antihistamine that treats runny nose and watery eyes. Phenylephrine is a decongestant that clears your sinuses.
Type of medication
Allegra DAdvil Allergy and Congestion Relief
DecongestantAntihistamine
2nd generation
Prescription or OTC
Antihistamine
1st generation
Pain reliever
NSAID
DecongestantOver-the-counter
Available as
Allegra DAdvil Allergy and Congestion Relief
  • Extended release
  • Pill
Used for (click to learn more)
Allegra DAdvil Allergy and Congestion Relief
Risk factors for serious side effects
Allegra DAdvil Allergy and Congestion Relief
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • History of high blood pressure
  • History of heart problems
  • Age 65 or older
  • History of seizure
  • Women of childbearing age
Detailed Allegra D (Pseudoephedrine / Fexofenadine) risks & warnings »
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Women of childbearing age
  • Kidney disease
  • Heart failure
  • Liver disease
  • Taking high blood pressure medications
  • Age 65 years or older
  • History of high blood pressure
  • History of heart problems
  • Age 65 years or older
  • Taking with aspirin
Detailed Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) risks & warnings »
Pregnancy category
Allegra DAdvil Allergy and Congestion Relief
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
Alcohol
No specific alcohol-related info.
  • While taking this, avoid alcohol and other drugs that make you drowsy.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
  • Talk to your doctor if you have high blood pressure or kidney problems before using it.
  • Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) contains ibuprofen, an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) for any amount of time.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
  • The antihistamine (fexofenadine) can cause dizziness, drowsiness, dry eyes/mouth, and constipation.
  • The decongestant (pseudoephedrine) can make your blood pressure higher and can make it harder to sleep.
  • Avoid taking it close to bedtime to prevent trouble sleeping.
  • While taking this, avoid alcohol and other drugs that make you drowsy.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
Allegra DAdvil Allergy and Congestion Relief
  • Available without a prescription in the drugstore.
  • It has two medications that work in different ways to help relieve nasal symptoms.
  • The antihistamine (fexofenadine) is useful for relieving itchy eyes, runny nose, or constant sneezing.
  • The decongestant (pseudoephedrine) is very good at relieving congestion.
  • Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) is a combination medicine that relieves multiple cold and allergy symptoms. It's good to use if you have a stuffy nose, sinus pressure, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
Downsides and risks
Allegra DAdvil Allergy and Congestion Relief
  • Has more side effects than Allegra since it has pseudoephedrine in it.
  • The antihistamine (fexofenadine) can cause dizziness, drowsiness, dry eyes/mouth, and constipation.
  • The decongestant (pseudoephedrine) can make your blood pressure higher and can make it harder to sleep.
  • You must show a photo ID to buy this from behind the pharmacy counter. There's a maximum limit on how much you can buy in the pharmacy at a time.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
  • It's not safe to take ibuprofen if you're pregnant since it increases the risk of heart defects in babies.
Tips from our pharmacists for people taking the medication
Allegra DAdvil Allergy and Congestion Relief
  • It works best if you have nasal congestion and a runny nose.
  • Take on an empty stomach, 1 hour before eating or 2 hours after eating.
  • Shouldn't be used in kids younger than 12 years old.
  • Avoid taking it close to bedtime to prevent trouble sleeping.
  • Can cause dizziness, headache, or a fast heartbeat.
  • Talk to your doctor if you have high blood pressure or kidney problems before using it.
  • If symptoms get worse or you need to use it for more than a few weeks, talk with your doctor.
  • Don't take it if you have an allergy to aspirin since ibuprofen can cause a similar reaction.
  • Chlorpheniramine (the antihistamine ingredient in Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine)) can make you sleepy, so avoid activities that require you to be fully alert until you know how it affects you.
  • While taking this, avoid alcohol and other drugs that make you drowsy.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Let your doctor know if your symptoms don't improve in a few days.
  • Don't use in kids age 12 years or younger.
Learn more
More about Allegra DSide effectsReviews & ratingsAlternativesFDA package insert
More about Advil Allergy and Congestion ReliefSide effectsReviews & ratingsAlternativesFDA package insert