Compare Allegra D vs. Alka-Seltzer Plus Night Cold and Flu

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Allegra D
(Pseudoephedrine / Fexofenadine)

Alka-Seltzer Plus Night Cold And Flu
(Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine)

Treats allergy symptoms and congestion. Allegra D (Pseudoephedrine / Fexofenadine) is a combination allergy medicine that's useful if you have congestion and runny nose.Relieves cold and flu symptoms, and helps you sleep. Alka-Seltzer Plus Night Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) is good for multiple cold symptoms at night, but it's more medicine than you need if you only have one symptom.
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Side effects
Allegra DAlka-Seltzer Plus Night Cold and Flu
  • Back pain 2%
More Allegra D side effects »

We haven’t found good data for Alka-Seltzer Plus Night Cold and Flu side effects.

FDA side effect reports for Alka-Seltzer Plus Night Cold and Flu »
How it works
Allegra DAlka-Seltzer Plus Night Cold and Flu
Allegra D (Pseudoephedrine / Fexofenadine) is a combination medicine that relieves allergy symptoms. Fexofenadine (an antihistamine) prevents allergy symptoms like runny nose, sneezing, and itching. Pseudoephedrine (a decongestant) clears your sinuses.Alka-Seltzer Plus Night Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Phenylephrine is a decongestant that clears your sinuses. Doxylamine is an antihistamine that relieves a runny nose and makes you very sleepy.
Type of medication
Allegra DAlka-Seltzer Plus Night Cold and Flu
DecongestantAntihistamine
2nd generation
Prescription or OTC
Pain reliever
Acetaminophen (APAP)
Antihistamine
Ethanolamine derivative
Cough suppressantDecongestantOver-the-counter
Available as
Allegra DAlka-Seltzer Plus Night Cold and Flu
  • Extended release
  • Pill
Used for (click to learn more)
Allegra DAlka-Seltzer Plus Night Cold and Flu
Risk factors for serious side effects
Allegra DAlka-Seltzer Plus Night Cold and Flu
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • History of high blood pressure
  • History of heart problems
  • Age 65 or older
  • History of seizure
  • Women of childbearing age
Detailed Allegra D (Pseudoephedrine / Fexofenadine) risks & warnings »
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
  • History of chronic obstructive pulmonary disease (COPD)
  • History of smoking
  • Taking with alcohol
  • Taking with other medicines that make you less alert
  • Age 65 years or older
  • Glaucoma
  • Benign prostatic hypertrophy (BPH)
  • Using other medications that affect serotonin
Detailed Alka-Seltzer Plus Night Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) risks & warnings »
Pregnancy category
Allegra DAlka-Seltzer Plus Night Cold and Flu
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
  • Talk to your doctor if you have high blood pressure or kidney problems before using it.
No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
  • The antihistamine (fexofenadine) can cause dizziness, drowsiness, dry eyes/mouth, and constipation.
  • The decongestant (pseudoephedrine) can make your blood pressure higher and can make it harder to sleep.
  • Avoid taking it close to bedtime to prevent trouble sleeping.
  • The antihistamine (doxylamine) can help you sleep.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
Allegra DAlka-Seltzer Plus Night Cold and Flu
  • Available without a prescription in the drugstore.
  • It has two medications that work in different ways to help relieve nasal symptoms.
  • The antihistamine (fexofenadine) is useful for relieving itchy eyes, runny nose, or constant sneezing.
  • The decongestant (pseudoephedrine) is very good at relieving congestion.
  • Alka-Seltzer Plus Night Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a cough, fever, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The cough suppressant (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • The antihistamine (doxylamine) can help you sleep.
Downsides and risks
Allegra DAlka-Seltzer Plus Night Cold and Flu
  • Has more side effects than Allegra since it has pseudoephedrine in it.
  • The antihistamine (fexofenadine) can cause dizziness, drowsiness, dry eyes/mouth, and constipation.
  • The decongestant (pseudoephedrine) can make your blood pressure higher and can make it harder to sleep.
  • You must show a photo ID to buy this from behind the pharmacy counter. There's a maximum limit on how much you can buy in the pharmacy at a time.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Tips from our pharmacists for people taking the medication
Allegra DAlka-Seltzer Plus Night Cold and Flu
  • It works best if you have nasal congestion and a runny nose.
  • Take on an empty stomach, 1 hour before eating or 2 hours after eating.
  • Shouldn't be used in kids younger than 12 years old.
  • Avoid taking it close to bedtime to prevent trouble sleeping.
  • Can cause dizziness, headache, or a fast heartbeat.
  • Talk to your doctor if you have high blood pressure or kidney problems before using it.
  • If symptoms get worse or you need to use it for more than a few weeks, talk with your doctor.
  • Alka-Seltzer Plus Night Cold And Flu (Acetaminophen / Doxylamine / Dextromethorphan / Phenylephrine) starts working in about 30 minutes.
  • Doxylamine (the antihistamine ingredient) can make you tired, so take it close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
Learn more
More about Allegra DSide effectsReviews & ratingsAlternativesFDA package insert
More about Alka-Seltzer Plus Night Cold and FluSide effectsReviews & ratingsAlternativesFDA package insert