Compare Allegra D vs. Flonase

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Allegra D
(pseudoephedrine / fexofenadine)

Flonase
(fluticasone)

Treats allergy symptoms and congestion. Allegra D (Pseudoephedrine / Fexofenadine) is a combination allergy medicine that's useful if you have congestion and runny nose.Relieves allergy symptoms. Flonase (Fluticasone) is a good first-choice medicine for treating a runny or stuffy nose caused by allergies, and it's cheaper than some alternatives.
Reviews & ratings
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Have you used Allegra D (pseudoephedrine / fexofenadine)?
Worth itNot sureNot worth it
Reviews for Flonase
72%
-1% worse vs. Allegra D
43%
+28% better vs. Allegra D
7%
+7% better vs. Allegra D
890 reviews
Have you used Flonase (fluticasone)?
Worth itNot sureNot worth it
Side effects
Allegra DFlonase
  • Headache 3%
  • Back pain 2%
  • Sleep difficulty 13%
  • Nausea 7%
  • Adverse effects 4%
  • Indigestion 3%
  • Dry mouth 3%
  • Dizziness 2%
  • Agitation 2%
More Allegra D side effects »
  • Asthma symptoms 4%
  • Nosebleed 1%
  • Nausea/vomiting 3%
  • Cough 1%
  • Blood in mucus 2%
  • Bronchitis 2%
  • Abdominal pain 2%
More Flonase side effects »
How it works
Allegra DFlonase
Allegra D (Pseudoephedrine / Fexofenadine) is a combination medicine that relieves allergy symptoms. Fexofenadine (an antihistamine) prevents allergy symptoms like runny nose, sneezing, and itching. Pseudoephedrine (a decongestant) clears your sinuses.Flonase (Fluticasone) is a nasal steroid. It works directly in your nose to reduce swelling and inflammation caused by allergies.
Type of medication
Allegra DFlonase
Prescription or OTCPrescription or OTC
Available as
Allegra DFlonase
  • Extended release
  • Nasal spray
Used for
Allegra DFlonase
Risk factors for serious side effects
Allegra DFlonase
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • History of high blood pressure
  • History of heart problems
  • Age 65 or older
Detailed Allegra D (pseudoephedrine / fexofenadine) risks & warnings »
  • Switching from oral or injectable steroids to inhaled, especially if used long term
  • Using other inhaled steroids with Flonase (Fluticasone)
  • Long-term use
  • Taking more than recommended dose
Detailed Flonase (fluticasone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Pain
Allegra DFlonase
No pain related info.
  • Long-term use of Flonase (Fluticasone) can increase your chances of getting thrush in the nose and throat. Your doctor will check your nose and throat if you have to be on this medication for a long time. Also, tell your doctor if you notice pain in the nose and throat with redness and white patches.
Sleep
Allegra DFlonase
  • The antihistamine (fexofenadine) can cause dizziness, drowsiness, dry eyes/mouth, and constipation.
No sleep related info.
Upsides and benefits
Allegra DFlonase
  • Available without a prescription in the drugstore.
  • It has two medications that work in different ways to help relieve nasal symptoms.
  • The antihistamine (fexofenadine) is useful for relieving itchy eyes, runny nose, or constant sneezing.
  • The decongestant (pseudoephedrine) is very good at relieving congestion.
  • First-choice medication for treating runny and stuffy noses caused by allergies. It works by reducing inflammation in the nose.
  • Because it's used directly where the inflammation is happening, it has fewer side effects than oral steroids do and has a lower chance of causing withdrawal symptoms once the medication is stopped.
  • Can be used as needed to help control symptoms in people age 13 years or older.
  • Available as a generic medication.
Downsides and risks
Allegra DFlonase
  • Has more side effects than Allegra since it has pseudoephedrine in it.
  • The antihistamine (fexofenadine) can cause dizziness, drowsiness, dry eyes/mouth, and constipation.
  • The decongestant (pseudoephedrine) can make your blood pressure higher and can make it harder to sleep.
  • You must show a photo ID to buy this from behind the pharmacy counter. There's a maximum limit on how much you can buy in the pharmacy at a time.
  • Flonase (Fluticasone) doesn't have a counter on it, so it can be hard to remember how many sprays are left (each bottle has 120 sprays).
  • Needs to be primed (pressed/pumped until a fine spray appears) up to six times prior to using it for the first time, or if you haven't used it in 2 weeks.
  • Since the medicine in Flonase (Fluticasone) is a steroid, it can slow down your healing process if you've hurt your nose or had nose surgery.
Tips from our pharmacists for people taking the medication
Allegra DFlonase
  • It works best if you have nasal congestion and a runny nose.
  • Take on an empty stomach, 1 hour before eating or 2 hours after eating.
  • Shouldn't be used in kids younger than 12 years old.
  • Avoid taking it close to bedtime to prevent trouble sleeping.
  • Can cause dizziness, headache, or a fast heartbeat.
  • Talk to your doctor if you have high blood pressure or kidney problems before using it.
  • If symptoms get worse or you need to use it for more than a few weeks, talk with your doctor.
  • It can take several days for Flonase (Fluticasone) to start working fully.
  • Don't take more of it than was prescribed for you.
  • Blow your nose before using Flonase (Fluticasone).
  • Can cause thrush (a fungal infection) inside the nose and throat.
  • Can also cause a headache, sore throat, or nosebleeds.
Learn more
More about Allegra DSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Allegra D (pseudoephedrine / fexofenadine)?
Worth itNot sureNot worth it
More about FlonaseSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Flonase (fluticasone)?
Worth itNot sureNot worth it