Compare Allegra-D vs. Nyquil Cold And Flu

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Allegra-D (fexofenadine / pseudoephedrine)

Over-the-counter
Treats allergy symptoms and congestion.

Allegra-D (fexofenadine / pseudoephedrine) is a combination allergy medicine that's useful if you have congestion and runny nose.

Relieves cold and flu symptoms, and helps you sleep.

Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.

5.3/ 7 average rating with 1188 reviewsforNyquil Cold And Flu
Upsides
  • Allegra-D (fexofenadine / pseudoephedrine) contains two medicines that work in different ways to help relieve multiple symptoms including nasal congestion and allergies.
  • Available without a prescription in the drugstore.
  • Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have watery eyes, a cough, fever, and pain.
  • The cough medicine (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • The antihistamine (doxylamine) will help you sleep.
Downsides
  • You must show a photo ID to purchase this medicine from behind the pharmacy counter. There's a maximum limit on how much Allegra-D (fexofenadine / pseudoephedrine) you can buy at a time.
  • Allegra-D (fexofenadine / pseudoephedrine) can have more side effects (such as increased blood pressure and difficulty sleeping) than Allegra since it has pseudoephedrine in it.
  • If you have severe high blood pressure or heart disease you can't take this medicine. If you have kidney damage, you may not be able to take Allegra-D (fexofenadine / pseudoephedrine).
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Used for
Dosage forms
  • Pill
  • Pill
  • Liquid
No pricing information available
No pricing information available
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Reviews
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1188 
83%
think this treatment is worth it
42%
think this treatment works well
7%
think this treatment is a hassle

Have you used Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine)?

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Side effects
10possible side effects
  • Headache
    13%
  • Trouble sleeping
    13%
  • Nausea
    7%
  • Dry Mouth
    3%
  • Indigestion
    3%
  • Throat irritation
    2%
  • Dizziness
    2%
  • Agitation
    2%
  • Back pain
    2%
  • Palpitations
    2%
See more detailed side effects
The Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • High blood pressure

    History of high blood pressure

  • Heart problems

    History of heart problems

    ...and 1 more risk factors

  • Seizure

    History of seizure

See more detailed risks and warnings
  • Liver damage

    Drinking more than 2 alcoholic beverages a day

    ...and 2 more risk factors

  • Serotonin syndrome

    Using other medications that affect serotonin

  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Antihistamine side effects

    Age 65 years or older

    ...and 2 more risk factors

See more detailed risks and warnings