Compare Allegra vs. Advil Allergy and Congestion Relief

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Allegra
(Fexofenadine)

Advil Allergy And Congestion Relief
(Chlorpheniramine / Ibuprofen / Phenylephrine)

Treats allergy symptoms. Allegra (Fexofenadine) relieves allergy symptoms without making you feel drowsy.Relieves cold and allergy symptoms. Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) is an okay combination medicine to relieve pain and congestion. The antihistamine can make you sleepy and the decongestant can keep you awake, so it could affect you either way.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.2727272727272725Allegra
Reviews for Allegra (Fexofenadine)
77%
of people say Allegra (Fexofenadine) is worth it
59%
say it works well
0%
say it's a big hassle
Reviews for Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine)
73%
4% vs. Allegra (Fexofenadine)
30%
29% vs. Allegra (Fexofenadine)
6%
6% vs. Allegra (Fexofenadine)
Side effects
AllegraAdvil Allergy and Congestion Relief
  • Vomiting 3%
  • Headache 3%
  • Cough 3%
  • Back pain 2%
  • Ear, nose, or throat infection 2%
  • Diarrhea 1%
  • Fever 1%
  • Runny nose 1%
  • Dizziness 1%
  • Stomach discomfort 1%
More Allegra side effects »

We haven’t found good data for Advil Allergy and Congestion Relief side effects.

FDA side effect reports for Advil Allergy and Congestion Relief »
How it works
AllegraAdvil Allergy and Congestion Relief
Allegra (Fexofenadine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions.Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) is a combination medicine that treats cold and allergy symptoms. Ibuprofen is an NSAID that relieves swelling, pain, and fever. Chlorpheniramine is an antihistamine that treats runny nose and watery eyes. Phenylephrine is a decongestant that clears your sinuses.
Type of medication
AllegraAdvil Allergy and Congestion Relief
Antihistamine
2nd generation
Prescription or OTC
Antihistamine
1st generation
Pain reliever
NSAID
DecongestantOver-the-counter
Available as
AllegraAdvil Allergy and Congestion Relief
  • Pill
  • Dissolving tablet
  • Liquid
  • Pill
Used for (click to learn more)
AllegraAdvil Allergy and Congestion Relief
Risk factors for serious side effects
AllegraAdvil Allergy and Congestion Relief
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • History of phenylketonuria (PKU)
Detailed Allegra (Fexofenadine) risks & warnings »
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Women of childbearing age
  • Kidney disease
  • Heart failure
  • Liver disease
  • Taking high blood pressure medications
  • Age 65 years or older
  • History of high blood pressure
  • History of heart problems
  • Age 65 years or older
  • Taking with aspirin
Detailed Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) risks & warnings »
Pregnancy category
AllegraAdvil Allergy and Congestion Relief
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
Alcohol
No specific alcohol-related info.
  • While taking this, avoid alcohol and other drugs that make you drowsy.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
  • The dose needs to be adjusted for people with kidney problems.
  • Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) contains ibuprofen, an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) for any amount of time.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
  • Won't make you feel drowsy like some antihistamine medicines.
  • While taking this, avoid alcohol and other drugs that make you drowsy.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
AllegraAdvil Allergy and Congestion Relief
  • Relieves allergy symptoms, like sneezing, runny nose, and itching.
  • Approved to be used in kids and adults age 6 months and older.
  • Won't make you feel drowsy like some antihistamine medicines.
  • Available over-the-counter without a prescription.
  • Comes in many forms, such as a tablet, liquid, or quick-dissolving tablet.
  • It's okay to take with most other medications since it has very few interactions.
  • Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine) is a combination medicine that relieves multiple cold and allergy symptoms. It's good to use if you have a stuffy nose, sinus pressure, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
Downsides and risks
AllegraAdvil Allergy and Congestion Relief
  • For some people, the effects Allegra (Fexofenadine) has on allergies will wear off over time.
  • May not work as well as the first-generation antihistamines, like diphenhydramine (Benadryl).
  • The dose needs to be adjusted for people with kidney problems.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
  • It's not safe to take ibuprofen if you're pregnant since it increases the risk of heart defects in babies.
Tips from our pharmacists for people taking the medication
AllegraAdvil Allergy and Congestion Relief
  • Starts working in 1 to 2 hours depending on what dosage form you're taking.
  • Works best when taken regularly, even before symptoms are expected to appear.
  • Can make you feel dizzy or sleepy, so you can take it at bedtime.
  • Follow age-specific dosing and don't take more than recommended.
  • If symptoms get worse or you need to use it for more than a few weeks, talk with your doctor.
  • Don't take it if you have an allergy to aspirin since ibuprofen can cause a similar reaction.
  • Chlorpheniramine (the antihistamine ingredient in Advil Allergy And Congestion Relief (Chlorpheniramine / Ibuprofen / Phenylephrine)) can make you sleepy, so avoid activities that require you to be fully alert until you know how it affects you.
  • While taking this, avoid alcohol and other drugs that make you drowsy.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Let your doctor know if your symptoms don't improve in a few days.
  • Don't use in kids age 12 years or younger.
Learn more
More about AllegraSide effectsReviews & ratingsAlternativesFDA package insert
More about Advil Allergy and Congestion ReliefSide effectsReviews & ratingsAlternativesFDA package insert