Compare Allegra vs. Clarinex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Allegra
(Fexofenadine)

Clarinex
(Desloratadine)

Treats allergy symptoms. Allegra (Fexofenadine) relieves allergy symptoms without making you feel drowsy.Treats allergy symptoms. Clarinex (Desloratadine) is a good option for once-daily allergy relief. It doesn't make you feel sleepy, but you need a prescription.
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Reviews & ratings
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Have you used Allegra (Fexofenadine)?
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Have you used Clarinex (Desloratadine)?
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Side effects
AllegraClarinex
  • Vomiting 3%
  • Headache 3%
  • Cough 3%
  • Back pain 2%
  • Ear, nose, or throat infection 2%
  • Diarrhea 1%
  • Fever 1%
  • Runny nose 1%
  • Dizziness 1%
  • Stomach discomfort 1%
More Allegra side effects »
  • Fever 12%
  • Diarrhea 12%
  • Ear, nose, or throat infection 8%
  • Middle ear inflammation 4%
  • Sore throat 3%
  • Loss of appetite 3%
  • Vomiting 3%
  • Runny nose 2%
  • Fatigue 1%
  • Mood swings 1%
More Clarinex side effects »
How it works
AllegraClarinex
Allegra (Fexofenadine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions.Clarinex (Desloratadine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions.
Type of medication
AllegraClarinex
Antihistamine
2nd generation
Prescription or OTC
Antihistamine
2nd generation
Prescription only
Available as
AllegraClarinex
  • Pill
  • Dissolving tablet
  • Liquid
  • Pill
  • Dissolving tablet
  • Liquid
Used for (click to learn more)
AllegraClarinex
Risk factors for serious side effects
AllegraClarinex
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • History of phenylketonuria (PKU)
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
AllegraClarinex
  • Some forms of Allegra (Fexofenadine) contain aspartame (phenylalanine). People who have phenylketonuria (PKU) can't break down the amino acid phenylalanine. It builds up and causes serious medical problems. If you have PKU, check to see which products you can use.
No food related info.
Kidneys and liver
AllegraClarinex
  • The dose needs to be adjusted for people with kidney problems.
No kidneys and liver related info.
Sleep
AllegraClarinex
  • Won't make you feel drowsy like some antihistamine medicines.
  • Can make you feel dizzy or sleepy, so you can take it at bedtime.
  • Preferred for older people since it causes little to no drowsiness compared to other antihistamines like Diphenhydramine (Benadryl).
  • Works faster than other non-drowsy antihistamines like Loratadine (Claritin).
  • Can give you a headache or diarrhea, but it rarely causes drowsiness or dizziness.
Upsides and benefits
AllegraClarinex
  • Relieves allergy symptoms, like sneezing, runny nose, and itching.
  • Approved to be used in kids and adults age 6 months and older.
  • Won't make you feel drowsy like some antihistamine medicines.
  • Available over-the-counter without a prescription.
  • Comes in many forms, such as a tablet, liquid, or quick-dissolving tablet.
  • It's okay to take with most other medications since it has very few interactions.
  • Relieves allergy symptoms like sneezing, runny nose, congestion, hives, or itchy skin.
  • Preferred for older people since it causes little to no drowsiness compared to other antihistamines like Diphenhydramine (Benadryl).
  • Works faster than other non-drowsy antihistamines like Loratadine (Claritin).
  • Side effects are rare and usually mild.
  • Available as a liquid or fast-dissolving tablet for people who don't like swallowing pills.
Downsides and risks
AllegraClarinex
  • For some people, the effects Allegra (Fexofenadine) has on allergies will wear off over time.
  • May not work as well as the first-generation antihistamines, like diphenhydramine (Benadryl).
  • The dose needs to be adjusted for people with kidney problems.
  • May not work as fast as the other antihistamines that make you sleepy (like Benadryl).
  • Not a good medication for pregnant women to take.
Tips from our pharmacists for people taking the medication
AllegraClarinex
  • Starts working in 1 to 2 hours depending on what dosage form you're taking.
  • Works best when taken regularly, even before symptoms are expected to appear.
  • Can make you feel dizzy or sleepy, so you can take it at bedtime.
  • Follow age-specific dosing and don't take more than recommended.
  • If symptoms get worse or you need to use it for more than a few weeks, talk with your doctor.
  • Starts working in an hour.
  • Take it once a day when needed.
  • Works the best if used regularly during allergy season.
  • Can give you a headache or diarrhea, but it rarely causes drowsiness or dizziness.
Learn more
More about AllegraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Allegra (Fexofenadine)?
Worth itNot sureNot worth it
More about ClarinexSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Clarinex (Desloratadine)?
Worth itNot sureNot worth it