Compare Allegra vs. Clarinex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Allegra
(fexofenadine)

Clarinex
(desloratadine)

Treats allergy symptoms. Allegra (Fexofenadine) relieves allergy symptoms without making you feel drowsy.Treats allergy symptoms. Clarinex (desloratadine) is a good option for once-daily allergy relief. It doesn't make you feel sleepy, but you need a prescription.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.38Allegra
Reviews for Allegra
79%
of people (All ages) say Allegra is worth it
63%
say it works well
0%
say it's a big hassle
Have you used Allegra (fexofenadine)?
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Have you used Clarinex (desloratadine)?
Worth itNot sureNot worth it
Side effects
AllegraClarinex
  • Dysmenorrhea 2%
  • Headache 3%
  • Back Pain 2%
  • Cough 3%
  • Upper Respiratory Tract Infection 2%
  • Pyrexia 1%
  • Otitis Media 2%
  • Rhinorrhea 1%
More Allegra side effects »
  • Sore throat 2%
  • Dry mouth 1%
  • Tiredness 1%
  • Headache 1%
  • Nausea 3%
  • Dizziness 1%
  • Stomach upset 2%
More Clarinex side effects »
How it works
AllegraClarinex
Allegra (Fexofenadine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions.Clarinex (desloratadine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions.
Type of medication
AllegraClarinex
Prescription or OTCPrescription only
Available as
AllegraClarinex
  • Pill
  • Dissolving tablet
  • Liquid
  • Pill
  • Dissolving tablet
  • Liquid
Used for
AllegraClarinex
Risk factors for serious side effects
AllegraClarinex
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • History of phenylketonuria (PKU)
Detailed Allegra (fexofenadine) risks & warnings »
    Detailed Clarinex (desloratadine) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Food
    AllegraClarinex
    • Some forms of Allegra (Fexofenadine) contain aspartame (phenylalanine). People who have phenylketonuria (PKU) can't break down the amino acid phenylalanine. It builds up and causes serious medical problems. If you have PKU, check to see which products you can use.
    • Take it once a day with or without food or as directed by your doctor.
    Kidneys and liver
    AllegraClarinex
    • The dose needs to be adjusted for people with kidney problems.
    No kidneys and liver related info.
    Sleep
    AllegraClarinex
    • Can make you feel dizzy or sleepy, so you can take it at bedtime.
    • Won't make you feel drowsy like some antihistamine medicines.
    • In some rare cases, causes drowsiness, dizziness, sore throat, or muscle pain.
    • Preferred for older people since it causes little to no drowsiness compared to other antihistamines like diphenhydramine (Benadryl).
    • Works faster than other non-drowsy antihistamines like loratadine (Claritin).
    Upsides and benefits
    AllegraClarinex
    • Relieves allergy symptoms, like sneezing, runny nose, and itching.
    • Approved to be used in kids and adults age 6 months and older.
    • Won't make you feel drowsy like some antihistamine medicines.
    • Available over-the-counter without a prescription.
    • Comes in many forms, such as a tablet, liquid, or quick-dissolving tablet.
    • It's okay to take with most other medications since it has very few interactions.
    • Clarinex (desloratadine) relieves allergy symptoms like sneezing, runny nose, congestion, hives, or itchy skin.
    • Preferred for older people since it causes little to no drowsiness compared to other antihistamines like diphenhydramine (Benadryl).
    • Works faster than other non-drowsy antihistamines like loratadine (Claritin).
    • Side effects are rare and usually mild.
    • Available as a liquid or fast-dissolving tablet for people who don't like swallowing pills.
    Downsides and risks
    AllegraClarinex
    • For some people, the effects Allegra (Fexofenadine) has on allergies will wear off over time.
    • May not work as well as the first-generation antihistamines, like diphenhydramine (Benadryl).
    • The dose needs to be adjusted for people with kidney problems.
    • May not work as fast as the other antihistamines that make you sleepy (like Benadryl).
    • Not a good medication for pregnant women to take.
    Tips from our pharmacists for people taking the medication
    AllegraClarinex
    • Starts working in 1 to 2 hours depending on what dosage form you're taking.
    • Works best when taken regularly, even before symptoms are expected to appear.
    • Can make you feel dizzy or sleepy, so you can take it at bedtime.
    • Follow age-specific dosing and don't take more than recommended.
    • If symptoms get worse or you need to use it for more than a few weeks, talk with your doctor.
    • Take it once a day with or without food or as directed by your doctor.
    • Works best if used regularly during allergy season.
    • Can give you headache or dry mouth.
    • In some rare cases, causes drowsiness, dizziness, sore throat, or muscle pain.
    Learn more
    More about AllegraSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Allegra (fexofenadine)?
    Worth itNot sureNot worth it
    More about ClarinexSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Clarinex (desloratadine)?
    Worth itNot sureNot worth it