Compare Allegra vs. Flonase

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Allegra
(fexofenadine)

Flonase
(fluticasone)

Treats allergy symptoms. Allegra (Fexofenadine) relieves allergy symptoms without making you feel drowsy.Relieves allergy symptoms. Flonase (Fluticasone) is a good first-choice medicine for treating a runny or stuffy nose caused by allergies, and it's cheaper than some alternatives.
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Reviews & ratings
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Have you used Allegra (fexofenadine)?
Worth itNot sureNot worth it
Reviews for Flonase (fluticasone)
72%
-7% worse vs. Allegra (fexofenadine)
43%
-20% worse vs. Allegra (fexofenadine)
7%
-7% worse vs. Allegra (fexofenadine)
890 reviews
Have you used Flonase (fluticasone)?
Worth itNot sureNot worth it
Side effects
AllegraFlonase
  • Menstrual cramps 2%
  • Headache 3%
  • Back pain 2%
  • Cough 3%
  • Ear, nose, or throat infection 2%
  • Fever 1%
  • Middle ear inflammation 2%
  • Runny nose 1%
More Allegra side effects »
  • Asthma symptoms 4%
  • Nosebleed 1%
  • Nausea/vomiting 3%
  • Cough 1%
  • Blood in mucus 2%
  • Bronchitis 2%
  • Abdominal pain 2%
More Flonase side effects »
How it works
AllegraFlonase
Allegra (Fexofenadine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions.Flonase (Fluticasone) is a nasal steroid. It works directly in your nose to reduce swelling and inflammation caused by allergies.
Type of medication
AllegraFlonase
Prescription or OTC
Prescription or OTC
Available as
AllegraFlonase
  • Pill
  • Dissolving tablet
  • Liquid
  • Nasal spray
Used for
AllegraFlonase
Risk factors for serious side effects
AllegraFlonase
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • History of phenylketonuria (PKU)
Detailed Allegra (fexofenadine) risks & warnings »
  • Switching from oral or injectable steroids to inhaled, especially if used long term
  • Using other inhaled steroids with Flonase (Fluticasone)
    • Long-term use
    • Taking more than recommended dose
    • Long-term use
    • Exposure to immunizable diseases (chickenpox and measles)
    • Exposure to tuberculosis
    • Surgery or trauma to the nose or sinuses
    • Long-term use
    Detailed Flonase (fluticasone) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Food
    AllegraFlonase
    • Some forms of Allegra (Fexofenadine) contain aspartame (phenylalanine). People who have phenylketonuria (PKU) can't break down the amino acid phenylalanine. It builds up and causes serious medical problems. If you have PKU, check to see which products you can use.
    No food related info.
    Kidneys and liver
    AllegraFlonase
    • The dose needs to be adjusted for people with kidney problems.
    No kidneys and liver related info.
    Pain
    AllegraFlonase
    No pain related info.
    • Long-term use of Flonase (Fluticasone) can increase your chances of getting thrush in the nose and throat. Your doctor will check your nose and throat if you have to be on this medication for a long time. Also, tell your doctor if you notice pain in the nose and throat with redness and white patches.
    Sleep
    AllegraFlonase
    • Won't make you feel drowsy like some antihistamine medicines.
    • Can make you feel dizzy or sleepy, so you can take it at bedtime.
    No sleep related info.
    Upsides and benefits
    AllegraFlonase
    • Relieves allergy symptoms, like sneezing, runny nose, and itching.
    • Approved to be used in kids and adults age 6 months and older.
    • Won't make you feel drowsy like some antihistamine medicines.
    • Available over-the-counter without a prescription.
    • Comes in many forms, such as a tablet, liquid, or quick-dissolving tablet.
    • It's okay to take with most other medications since it has very few interactions.
    • First-choice medication for treating runny and stuffy noses caused by allergies. It works by reducing inflammation in the nose.
    • Because it's used directly where the inflammation is happening, it has fewer side effects than oral steroids do and has a lower chance of causing withdrawal symptoms once the medication is stopped.
    • Can be used as needed to help control symptoms in people age 13 years or older.
    • Available as a generic medication.
    Downsides and risks
    AllegraFlonase
    • For some people, the effects Allegra (Fexofenadine) has on allergies will wear off over time.
    • May not work as well as the first-generation antihistamines, like diphenhydramine (Benadryl).
    • The dose needs to be adjusted for people with kidney problems.
    • Flonase (Fluticasone) doesn't have a counter on it, so it can be hard to remember how many sprays are left (each bottle has 120 sprays).
    • Needs to be primed (pressed/pumped until a fine spray appears) up to six times prior to using it for the first time, or if you haven't used it in 2 weeks.
    • Since the medicine in Flonase (Fluticasone) is a steroid, it can slow down your healing process if you've hurt your nose or had nose surgery.
    Tips from our pharmacists for people taking the medication
    AllegraFlonase
    • Starts working in 1 to 2 hours depending on what dosage form you're taking.
    • Works best when taken regularly, even before symptoms are expected to appear.
    • Can make you feel dizzy or sleepy, so you can take it at bedtime.
    • Follow age-specific dosing and don't take more than recommended.
    • If symptoms get worse or you need to use it for more than a few weeks, talk with your doctor.
    • It can take several days for Flonase (Fluticasone) to start working fully.
    • Don't take more of it than was prescribed for you.
    • Blow your nose before using Flonase (Fluticasone).
    • Can cause thrush (a fungal infection) inside the nose and throat.
    • Can also cause a headache, sore throat, or nosebleeds.
    Learn more
    More about AllegraSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Allegra (fexofenadine)?
    Worth itNot sureNot worth it
    More about FlonaseSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Flonase (fluticasone)?
    Worth itNot sureNot worth it