Compare Allegra vs. Nyquil Cold And Flu

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Allegra
(fexofenadine)

Nyquil Cold And Flu
(acetaminophen / dextromethorphan / doxylamine)

Treats allergy symptoms. Allegra (Fexofenadine) relieves allergy symptoms without making you feel drowsy.Relieves cold and flu symptoms, and helps you sleep. Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.
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Best available price for 30 (24 hour) tablets of fexofenadine
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Reviews & ratings
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5.38Allegra
Reviews for Allegra (fexofenadine)
79%
of people (All ages) say Allegra (fexofenadine) is worth it
63%
say it works well
0%
say it's a big hassle
Have you used Allegra (fexofenadine)?
Worth itNot sureNot worth it
Reviews for Nyquil Cold And Flu (acetaminophen / dextromethorphan / doxylamine)
83%
+4% better vs. Allegra (fexofenadine)
42%
-21% worse vs. Allegra (fexofenadine)
7%
-7% worse vs. Allegra (fexofenadine)
1188 reviews
Have you used Nyquil Cold And Flu (acetaminophen / dextromethorphan / doxylamine)?
Worth itNot sureNot worth it
Side effects
AllegraNyquil Cold And Flu
  • Menstrual cramps 2%
  • Headache 3%
  • Back pain 2%
  • Cough 3%
  • Ear, nose, or throat infection 2%
  • Fever 1%
  • Middle ear inflammation 2%
  • Runny nose 1%
More Allegra side effects »

We haven’t found good data for Nyquil Cold And Flu side effects.

FDA side effect reports for Nyquil Cold And Flu »
How it works
AllegraNyquil Cold And Flu
Allegra (Fexofenadine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions.Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Doxylamine is an antihistamine that relieves a runny nose and makes you very sleepy.
Type of medication
AllegraNyquil Cold And Flu
Prescription or OTC
Over-the-counter
Available as
AllegraNyquil Cold And Flu
  • Pill
  • Dissolving tablet
  • Liquid
  • Pill
  • Liquid
Used for
AllegraNyquil Cold And Flu
Risk factors for serious side effects
AllegraNyquil Cold And Flu
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • History of phenylketonuria (PKU)
Detailed Allegra (fexofenadine) risks & warnings »
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • Using other medications that affect serotonin
  • Taking with alcohol
Detailed Nyquil Cold And Flu (acetaminophen / dextromethorphan / doxylamine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
AllegraNyquil Cold And Flu
No alcohol related info.
  • Avoid using alcohol and other drugs that make you drowsy.
Food
AllegraNyquil Cold And Flu
  • Some forms of Allegra (Fexofenadine) contain aspartame (phenylalanine). People who have phenylketonuria (PKU) can't break down the amino acid phenylalanine. It builds up and causes serious medical problems. If you have PKU, check to see which products you can use.
No food related info.
Kidneys and liver
AllegraNyquil Cold And Flu
  • The dose needs to be adjusted for people with kidney problems.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Pain
AllegraNyquil Cold And Flu
No pain related info.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Sleep
AllegraNyquil Cold And Flu
  • Won't make you feel drowsy like some antihistamine medicines.
  • Can make you feel dizzy or sleepy, so you can take it at bedtime.
No sleep related info.
Upsides and benefits
AllegraNyquil Cold And Flu
  • Relieves allergy symptoms, like sneezing, runny nose, and itching.
  • Approved to be used in kids and adults age 6 months and older.
  • Won't make you feel drowsy like some antihistamine medicines.
  • Available over-the-counter without a prescription.
  • Comes in many forms, such as a tablet, liquid, or quick-dissolving tablet.
  • It's okay to take with most other medications since it has very few interactions.
  • Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have watery eyes, a cough, fever, and pain.
  • The cough medicine (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • The antihistamine (doxylamine) will help you sleep.
Downsides and risks
AllegraNyquil Cold And Flu
  • For some people, the effects Allegra (Fexofenadine) has on allergies will wear off over time.
  • May not work as well as the first-generation antihistamines, like diphenhydramine (Benadryl).
  • The dose needs to be adjusted for people with kidney problems.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Tips from our pharmacists for people taking the medication
AllegraNyquil Cold And Flu
  • Starts working in 1 to 2 hours depending on what dosage form you're taking.
  • Works best when taken regularly, even before symptoms are expected to appear.
  • Can make you feel dizzy or sleepy, so you can take it at bedtime.
  • Follow age-specific dosing and don't take more than recommended.
  • If symptoms get worse or you need to use it for more than a few weeks, talk with your doctor.
  • Doxylamine (the antihistamine ingredient) can make you tired, so take it close to bedtime.
  • Follow age-specific dosing instructions on how much to take. Don't take more than recommended on the package.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Avoid using alcohol and other drugs that make you drowsy.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
Learn more
More about AllegraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Allegra (fexofenadine)?
Worth itNot sureNot worth it
More about Nyquil Cold And FluSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Nyquil Cold And Flu (acetaminophen / dextromethorphan / doxylamine)?
Worth itNot sureNot worth it