Compare Allegra vs. Nyquil Cold and Flu

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Nyquil Cold And Flu
(Acetaminophen / Dextromethorphan / Doxylamine)

Treats allergy symptoms. Allegra (Fexofenadine) relieves allergy symptoms without making you feel drowsy.Relieves cold and flu symptoms, and helps you sleep. Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.
How it works
Allegra (Fexofenadine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions.Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Doxylamine is an antihistamine that relieves a runny nose and makes you very sleepy.
Type of medication
2nd generation
Prescription or OTC
Pain reliever
Cough suppressantAntihistamine
Ethanolamine derivative
Available as
  • Pill
  • Dissolving tablet
  • Liquid
  • Pill
  • Liquid
Used for (click to learn more)
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
Reviews for Allegra (Fexofenadine)
of people say Allegra (Fexofenadine) is worth it
say it works well
say it's a big hassle
Reviews for Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine)
+6% vs. Allegra (Fexofenadine)
17% vs. Allegra (Fexofenadine)
6% vs. Allegra (Fexofenadine)
Side effects
  • Vomiting 3%
  • Headache 3%
  • Cough 3%
  • Back pain 2%
  • Ear, nose, or throat infection 2%
  • Diarrhea 1%
  • Fever 1%
  • Runny nose 1%
  • Dizziness 1%
  • Stomach discomfort 1%
More Allegra side effects »

We haven’t found good data for Nyquil Cold and Flu side effects.

FDA side effect reports for Nyquil Cold and Flu »
Risk factors for serious side effects
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • History of phenylketonuria (PKU)
Detailed Allegra (Fexofenadine) risks & warnings »
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • Using other medications that affect serotonin
  • Taking with alcohol
  • Taking with other medicines that make you less alert
  • Age 65 years or older
  • Glaucoma
  • Benign prostatic hypertrophy (BPH)
Detailed Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) risks & warnings »
Pregnancy category
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
No specific alcohol-related info.
  • Avoid using alcohol and other drugs that make you drowsy.
No specific food-related info.No specific food-related info.
Kidneys and liver
  • The dose needs to be adjusted for people with kidney problems.
No specific kidneys and liver-related info.
No specific sex-related info.No specific sex-related info.
No specific sleep-related info.
  • The antihistamine (doxylamine) will help you sleep.
No specific weight-related info.No specific weight-related info.
Upsides and benefits
  • Relieves allergy symptoms, like sneezing, runny nose, and itching.
  • Approved to be used in kids and adults age 6 months and older.
  • Won't make you feel drowsy like some antihistamine medicines.
  • Available over-the-counter without a prescription.
  • Comes in many forms, such as a tablet, liquid, or quick-dissolving tablet.
  • It's okay to take with most other medications since it has very few interactions.
  • Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have watery eyes, a cough, fever, and pain.
  • The cough medicine (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • The antihistamine (doxylamine) will help you sleep.
Downsides and risks
  • For some people, the effects Allegra (Fexofenadine) has on allergies will wear off over time.
  • May not work as well as the first-generation antihistamines, like diphenhydramine (Benadryl).
  • The dose needs to be adjusted for people with kidney problems.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Tips from our pharmacists for people taking the medication
  • Starts working in 1 to 2 hours depending on what dosage form you're taking.
  • Works best when taken regularly, even before symptoms are expected to appear.
  • Can make you feel dizzy or sleepy, so you can take it at bedtime.
  • Follow age-specific dosing and don't take more than recommended.
  • If symptoms get worse or you need to use it for more than a few weeks, talk with your doctor.
  • Doxylamine (the antihistamine ingredient) can make you tired, so take it close to bedtime.
  • Follow age-specific dosing instructions on how much to take. Don't take more than recommended on the package.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Avoid using alcohol and other drugs that make you drowsy.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
Learn more
More about AllegraSide effectsReviews & ratingsAlternativesFDA package insert
More about Nyquil Cold and FluSide effectsReviews & ratingsAlternativesFDA package insert