Compare Allegra vs. Zyrtec

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Allegra (Fexofenadine)

Prescription or OTC

Zyrtec (Cetirizine)

Prescription or OTC
Treats allergy symptoms.

Allegra (Fexofenadine) relieves allergy symptoms without making you feel drowsy.

5.4/ 7 average rating with 24 reviewsforAllegra
Treats allergy symptoms.

Zyrtec (Cetirizine) is a once-daily allergy relief medication that won't make you feel too sleepy.

5.2/ 7 average rating with 1232 reviewsforZyrtec
Upsides
  • Relieves allergy symptoms, like sneezing, runny nose, and itching.
  • Approved to be used in kids and adults age 6 months and older.
  • Won't make you feel drowsy like some antihistamine medicines.
  • Available over-the-counter without a prescription.
  • Comes in many forms, such as a tablet, liquid, or quick-dissolving tablet.
  • It's okay to take with most other medications since it has very few interactions.
  • Zyrtec (Cetirizine) works as well as other antihistamines to treat sneezing and runny nose, but causes less sedation.
  • Works well to also treat hives and itchy skin.
  • Zyrtec (Cetirizine) is available over the counter without a prescription.
  • It comes as a tablet, liquid, and quick-dissolving tablet.
  • It can provide quick relief of allergy symptoms for both kids and adults.
  • It's okay to take with most other medications because it has few drug interactions.
  • Most people don't get any side effects from Zyrtec (Cetirizine).
Downsides
  • For some people, the effects Allegra (Fexofenadine) has on allergies will wear off over time.
  • May not work as well as the first-generation antihistamines, like diphenhydramine (Benadryl).
  • The dose needs to be adjusted for people with kidney problems.
  • Although it works fast, its effectiveness wears off for some people over time.
  • Zyrtec (Cetirizine) can be slightly more sedating than Allegra or Claritin.
  • Some people find that other more sedating antihistamines, like Benadryl, are more effective for them than Zyrtec (Cetirizine).
  • If you have daily allergy symptoms, a prescription nasal steroid spray might be better for you long-term.
Used for
Dosage forms
  • Pill
  • Dissolving tablet
  • Liquid
  • Pill
  • Liquid capsule
  • Dissolving tablet
  • Liquid
No pricing information available
No pricing information available
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Reviews
24 
79%
think this treatment is worth it
63%
think this treatment works well
0%
think this treatment is a hassle

Have you used Allegra (Fexofenadine)?

Leave a review
1232 
76%
think this treatment is worth it
47%
think this treatment works well
7%
think this treatment is a hassle

Have you used Zyrtec (Cetirizine)?

Leave a review
Side effects
4possible side effects
  • Dizziness
    2%
  • Back Pain
    2%
  • Stomach Discomfort
    2%
  • Pain in extremity
    2%
See more detailed side effects
The Zyrtec (Cetirizine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Brain damage from too much phenylalanine

    History of phenylketonuria (PKU)

See more detailed risks and warnings
  • Increased side effects

    Age 65 or older

  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Overdosage

    Current kidney disease

    ...and 1 more risk factors

See more detailed risks and warnings