Compare Allegra vs. Zyrtec D

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Allegra (Fexofenadine)

Prescription or OTC
Treats allergy symptoms.

Allegra (Fexofenadine) relieves allergy symptoms without making you feel drowsy.

5.4/ 7 average rating with 24 reviewsforAllegra
Relieves congestion and allergy symptoms.

Zyrtec D (Cetirizine / Pseudoephedrine) relieves allergies and congestion without causing daytime sleepiness. It can keep you up at night if you take it too close to bedtime.

5.1/ 7 average rating with 927 reviewsforZyrtec D
Upsides
  • Relieves allergy symptoms, like sneezing, runny nose, and itching.
  • Approved to be used in kids and adults age 6 months and older.
  • Won't make you feel drowsy like some antihistamine medicines.
  • Available over-the-counter without a prescription.
  • Comes in many forms, such as a tablet, liquid, or quick-dissolving tablet.
  • It's okay to take with most other medications since it has very few interactions.
  • The antihistamine (Cetirizine) in Zyrtec D (Cetirizine / Pseudoephedrine) causes less drowsiness than other medications like Benadryl.
  • The decongestant (Pseudoephedrine) in Zyrtec D (Cetirizine / Pseudoephedrine) is stronger than other decongestants. It can also help relieve congestion-related headaches and ear pressure.
  • The stimulant effects of Pseudoephedrine can give you some extra energy during the day.
  • Doesn't give you rebound congestion (worse congestion symptoms after you stop taking the medicine) like decongestant nose sprays can.
  • It's available without a prescription, unlike other strong allergy medicines.
Downsides
  • For some people, the effects Allegra (Fexofenadine) has on allergies will wear off over time.
  • May not work as well as the first-generation antihistamines, like diphenhydramine (Benadryl).
  • The dose needs to be adjusted for people with kidney problems.
  • You can have more side effects when using combination pills than when using single-ingredient medications.
  • The antihistamine (Cetirizine) can cause more drowsiness than similar antihistamines, like Allegra D (which contains Fexofenadine) and Claritin D (which contains Loratadine).
  • The decongestant (Pseudoephedrine) can make your heart race or give you anxious or restless feelings.
  • You might not sleep as well due to Pseudoephedrine's effects and you can also have strange dreams while taking it.
  • Pseudoephedrine can raise your blood pressure, so don't take it if you have high blood pressure or other heart conditions.
  • Although you don't need a prescription, you do need to show a photo ID to buy this from behind the pharmacy counter.
Used for
Dosage forms
  • Pill
  • Dissolving tablet
  • Liquid
  • Extended release
No pricing information available
No pricing information available
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Reviews
24 
79%
think this treatment is worth it
63%
think this treatment works well
0%
think this treatment is a hassle

Have you used Allegra (Fexofenadine)?

Leave a review
927 
75%
think this treatment is worth it
43%
think this treatment works well
9%
think this treatment is a hassle

Have you used Zyrtec D (Cetirizine / Pseudoephedrine)?

Leave a review
Side effects
4possible side effects
  • Dizziness
    2%
  • Back Pain
    2%
  • Stomach Discomfort
    2%
  • Pain in extremity
    2%
See more detailed side effects
The Zyrtec D (Cetirizine / Pseudoephedrine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Brain damage from too much phenylalanine

    History of phenylketonuria (PKU)

See more detailed risks and warnings
  • High blood pressure

    History of high blood pressure

  • Heart problems

    History of heart problems

    ...and 1 more risk factors

  • Seizure

    History of seizure

  • Harm to fetus

    Women of childbearing age

  • Increased side effects

    Age 65 years or older

  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Overdosage

    Current kidney disease

    ...and 1 more risk factors

See more detailed risks and warnings