Compare Allopurinol vs. Benemid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zyloprim (allopurinol)

Prescription only

Benemid (probenecid)

Prescription only
Lowers uric acid levels in blood, and prevents gout flare-ups.

Zyloprim (allopurinol) works well to prevent gout attacks and is cheaper than some alternatives, but it takes a few weeks to start working.

5.0/ 7 average rating with 21 reviewsforAllopurinol
Lowers uric acid levels and strengthens penicillin's effect.

Benemid (probenecid) can be used to lower high uric acid levels in people with gout, but it is not a first-choice treatment because it takes a long time to kick in.

  • Zyloprim (allopurinol) works well to lower uric acid in the body.
  • It is available as a generic medication.
  • Benemid (probenecid) is available in generic.
  • It can raise levels of certain antibiotics in the body and make those antibiotics work better.
  • It is recommended as a second-choice medicine to help lower uric acid levels if they're not going down fast enough.
  • Zyloprim (allopurinol) can raise the number of gout attacks in the first few weeks.
  • It can take 2 to 6 weeks to feel the full effects of Zyloprim (allopurinol).
  • Kidney stones can form while taking Zyloprim (allopurinol), so you need to drink a lot of fluids to help prevent this.
  • Benemid (probenecid) is not a first-choice treatment for gout because it takes a while to kick in.
  • It doesn't work well in people who are using aspirin, or have kidney problems.
  • You have to take Benemid (probenecid) 2 times a day. Other stronger drugs for gout are only taken 1 time a day.
Used for
Dosage forms
  • Pill
  • Injection
  • Pill
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Side effects
The Zyloprim (allopurinol) FDA package insert doesn’t have numbers about how common side effects are.
The Benemid (probenecid) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Kidney stones

    History of kidney stones

  • Sleepiness or dizziness

    Taking other medications that also cause sleepiness

    ...and 3 more risk factors

See more detailed risks and warnings
  • Blood disorders

    Glucose-6-phosphate dehydrogenase (G6PD) deficiency

  • Gout attacks

    Taking Benemid (probenecid) for the first few weeks

  • Kidney problems

    History of kidney problems

  • Stomach ulcers

    History of esophagus or stomach problems, including ulcers

See more detailed risks and warnings