Compare Allopurinol vs. Benemid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zyloprim
(allopurinol)

Benemid
(probenecid)

Prevents gout flare-ups. Zyloprim (Allopurinol) works well to prevent gout attacks and is cheaper than some alternatives, but it takes a few weeks to kick in.Coming soon.
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Prices and coupon for 30 (300mg) tablets of allopurinol
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Prices and coupon for 60 (500mg) tablets of probenecid
Reviews & ratings
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Have you used Zyloprim (allopurinol)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Benemid (probenecid)?
Worth itNot sureNot worth it
Side effects
AllopurinolBenemid
  • Acute attacks of gout 6%
  • Skin rash 3%
More Allopurinol side effects »

We haven’t found good data for Benemid side effects.

FDA side effect reports for Benemid »
How it works
AllopurinolBenemid
Zyloprim (Allopurinol) is a type of medicine called a xanthine oxidase inhibitor. It lowers uric acid levels in your blood, which prevents gout attacks and certain types of kidney stones.Coming soon.
Type of medication
AllopurinolBenemid
Prescription only
Available as
AllopurinolBenemid
  • Pill
  • Pill
Used for
AllopurinolBenemid
  • Antibiotic Therapy Adjunct Gonorrhea
Risk factors for serious side effects
AllopurinolBenemid
          Detailed Zyloprim (allopurinol) risks & warnings »
          Coming soon.
          Pregnancy

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          Food
          AllopurinolBenemid
          • Take with food or milk to prevent an upset stomach.
          No food related info.
          Upsides and benefits
          AllopurinolBenemid
          • Works well to lower the amount of uric acid in the body to reduce gout attacks.
          • Available as a generic medication.
          Coming soon
          Downsides and risks
          AllopurinolBenemid
          • Can actually increase the number of gout attacks in the first few weeks.
          • It can take 2 to 6 weeks to feel the full effects of the medication.
          • You should drink a lot of fluids to prevent kidney stones from forming while taking this medication.
          Coming soon
          Tips from our pharmacists for people taking the medication
          AllopurinolBenemid
          • Drink plenty of water while taking this medication.
          • Take with food or milk to prevent an upset stomach.
          • It takes at least 2 to 6 weeks to experience the full benefit of this medication.
          • Your doctor can run blood tests to make sure the medication is working as it should.
          Coming soon
          Learn more
          More about AllopurinolSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Zyloprim (allopurinol)?
          Worth itNot sureNot worth it
          More about BenemidSide effectsFDA package insert
          Have you used Benemid (probenecid)?
          Worth itNot sureNot worth it