Compare Allopurinol vs. Benemid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zyloprim
(Allopurinol)

Benemid
(Probenecid)

Prevents gout flare-ups. Zyloprim (Allopurinol) works well to prevent gout attacks and is cheaper than some alternatives, but it takes a few weeks to kick in.Coming soon.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.0476190476190474Allopurinol
Reviews for Zyloprim (Allopurinol)
71%
of people say Zyloprim (Allopurinol) is worth it
52%
say it works well
5%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
AllopurinolBenemid

The Allopurinol FDA package insert doesn’t have numbers about how common side effects are.

More about Allopurinol side effects »

We haven’t found good data for Benemid side effects.

FDA side effect reports for Benemid »
How it works
AllopurinolBenemid
Zyloprim (Allopurinol) is a type of medicine called a xanthine oxidase inhibitor. It lowers uric acid levels in your blood, which prevents gout attacks and certain types of kidney stones.Coming soon.
Type of medication
AllopurinolBenemid
Antigout
Xanthine oxidase inhibitor
Prescription only
Coming soon.
Available as
AllopurinolBenemid
  • Pill
  • Pill
Used for (click to learn more)
AllopurinolBenemid
  • Antibiotic therapy; Adjunct Gonorrhea
Risk factors for serious side effects
AllopurinolBenemid
          Detailed Zyloprim (Allopurinol) risks & warnings »
          Coming soon.
          Pregnancy category
          AllopurinolBenemid
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          • Take with food or milk to prevent an upset stomach.
          No specific food-related info.
          Kidneys and liver
          • You should drink a lot of fluids to prevent kidney stones from forming while taking this medication.
          • People who take Zyloprim (Allopurinol) can be more likely to have kidney stones, especially if you're dehydrated. Drink at least 10 to 12 eight ounce glasses of water every day to help prevent that from happening.
          No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          AllopurinolBenemid
          • Works well to lower the amount of uric acid in the body to reduce gout attacks.
          • Available as a generic medication.
          Coming soon.
          Downsides and risks
          AllopurinolBenemid
          • Can actually increase the number of gout attacks in the first few weeks.
          • It can take 2 to 6 weeks to feel the full effects of the medication.
          • You should drink a lot of fluids to prevent kidney stones from forming while taking this medication.
          Coming soon.
          Tips from our pharmacists for people taking the medication
          AllopurinolBenemid
          • Drink plenty of water while taking this medication.
          • Take with food or milk to prevent an upset stomach.
          • It takes at least 2 to 6 weeks to experience the full benefit of this medication.
          • Your doctor can run blood tests to make sure the medication is working as it should.
          Coming soon.
          Learn more
          More about AllopurinolSide effectsReviews & ratingsAlternativesFDA package insert
          More about BenemidSide effectsFDA package insert