Compare Allopurinol vs. Colcrys

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zyloprim (allopurinol)

Prescription only

Colcrys (colchicine)

Prescription only
Lowers uric acid levels in blood, and prevents gout flare-ups.

Zyloprim (allopurinol) works well to prevent gout attacks and is cheaper than some alternatives, but it takes a few weeks to start working.

5.0/ 7 average rating with 21 reviewsforAllopurinol
Prevents and treats gout.

Colcrys (colchicine) is a second-choice treatment for gout attacks. Be careful how much you use since it can cause problems with your blood.

Upsides
  • Zyloprim (allopurinol) works well to lower uric acid in the body.
  • It is available as a generic medication.
  • Colcrys (colchicine) treats and stops sudden gout attacks.
  • It can be used to prevent gout when people are first starting on allopurinol.
  • Colcrys (colchicine) also treats Familial Mediterranean fever.
Downsides
  • Zyloprim (allopurinol) can raise the number of gout attacks in the first few weeks.
  • It can take 2 to 6 weeks to feel the full effects of Zyloprim (allopurinol).
  • Kidney stones can form while taking Zyloprim (allopurinol), so you need to drink a lot of fluids to help prevent this.
  • Colcrys (colchicine) doesn't work as well as nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids to treat gout attacks.
  • Taking Colcrys (colchicine) for too long can cause problems with your blood.
  • Doses needs to be changed if you have kidney or liver problems.
  • While Colcrys (colchicine) stops the redness and swelling of gout attacks, it doesn't stop the pain.
  • If you're taking Colcrys (colchicine) to stop gout flare-ups, you can only use it for 3 to 6 months after your levels have stabilized.
  • The capsules (Mitigare) are only approved for prevention, but not treatment of gout.
Used for
Dosage forms
  • Pill
  • Injection
  • Pill
Price
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$4
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$190.5
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Reviews
21 
71%
think this treatment is worth it
52%
think this treatment works well
5%
think this treatment is a hassle

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Side effects
The Zyloprim (allopurinol) FDA package insert doesn’t have numbers about how common side effects are.
The Colcrys (colchicine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Kidney stones

    History of kidney stones

  • Sleepiness or dizziness

    Taking other medications that also cause sleepiness

    ...and 3 more risk factors

See more detailed risks and warnings
  • Food and medicine interactions

    Grapefruit

    ...and 7 more risk factors

  • Muscle pain and breakdown

    Kidney problems

    ...and 3 more risk factors

See more detailed risks and warnings