Compare Allopurinol vs. Colcrys

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zyloprim
(Allopurinol)

Colcrys
(Colchicine)

Prevents gout flare-ups. Zyloprim (Allopurinol) works well to prevent gout attacks and is cheaper than some alternatives, but it takes a few weeks to kick in.Prevents and treats gout. Colcrys (Colchicine) is a second-choice treatment for gout attacks. Be careful how much you use since it causes a lot of side effects.
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Reviews & ratings
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Have you used Zyloprim (Allopurinol)?
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Have you used Colcrys (Colchicine)?
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Side effects
AllopurinolColcrys

The Allopurinol FDA package insert doesn’t have numbers about how common side effects are.

More about Allopurinol side effects »

The Colcrys FDA package insert doesn’t have numbers about how common side effects are.

More about Colcrys side effects »
How it works
AllopurinolColcrys
Zyloprim (Allopurinol) is a type of medicine called a xanthine oxidase inhibitor. It lowers uric acid levels in your blood, which prevents gout attacks and certain types of kidney stones.Colcrys (Colchicine) is a second choice antigout medication that prevents acute gout attacks by reducing inflammation.
Type of medication
AllopurinolColcrys
Antigout
Xanthine oxidase inhibitor
Prescription only
AntigoutPrescription only
Available as
AllopurinolColcrys
  • Pill
  • Pill
Used for (click to learn more)
AllopurinolColcrys
Risk factors for serious side effects
AllopurinolColcrys
    Detailed risks & warnings »
      Detailed risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Food
      AllopurinolColcrys
      • Take with food or milk to prevent an upset stomach.
      • Take it with or without food.
      Kidneys and liver
      AllopurinolColcrys
      No kidneys and liver related info.
      • Doses needs to be adjusted if you have kidney or liver problems.
      • People on Colcrys (Colchicine) have reported muscle pain which can lead to muscle and kidney damage. This has been very rare. Talk to your doctor if you develop sudden muscle pain, weakness, or a fever and you don't know why.
      Pain
      AllopurinolColcrys
      No pain related info.
      • Doesn't have the ability to ease or treat pain.
      Upsides and benefits
      AllopurinolColcrys
      • Works well to lower the amount of uric acid in the body to reduce gout attacks.
      • Available as a generic medication.
      • Is an antigout medication that has anti-inflammatory properties to help treat sudden gout attacks.
      • Lowers the risk of sudden gout attacks when taken as prescribed to prevent gout attacks.
      • Also treats Familial Mediterranean Fever.
      Downsides and risks
      AllopurinolColcrys
      • Can actually increase the number of gout attacks in the first few weeks.
      • It can take 2 to 6 weeks to feel the full effects of the medication.
      • You should drink a lot of fluids to prevent kidney stones from forming while taking this medication.
      • Doesn't work as well as nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids to treat gout attacks.
      • Taking too much can cause serious side effects.
      • Doses needs to be adjusted if you have kidney or liver problems.
      • Doesn't have the ability to ease or treat pain.
      Tips from our pharmacists for people taking the medication
      AllopurinolColcrys
      • Drink plenty of water while taking this medication.
      • Take with food or milk to prevent an upset stomach.
      • It takes at least 2 to 6 weeks to experience the full benefit of this medication.
      • Your doctor can run blood tests to make sure the medication is working as it should.
      • Take it with or without food.
      • At the first sign of a gout attack, take two tablets. Don't take more than three tablets a day in order to avoid serious side effects.
      • Wait at least 3 days before another using Colcrys (Colchicine) again.
      • Almost all people experience some nausea, vomiting, or diarrhea after taking Colcrys (Colchicine).
      • Let your doctor know of any serious nausea, vomiting, diarrhea, or if you have tingling in your fingers or toes.
      Learn more
      More about AllopurinolSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Zyloprim (Allopurinol)?
      Worth itNot sureNot worth it
      More about ColcrysSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Colcrys (Colchicine)?
      Worth itNot sureNot worth it