Compare Allopurinol vs. Colcrys

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zyloprim
(Allopurinol)

Colcrys
(Colchicine)

Prevents gout flare-ups. Zyloprim (Allopurinol) works well to prevent gout attacks and is cheaper than some alternatives, but it takes a few weeks to kick in.Prevents and treats gout. Colcrys (Colchicine) is a second-choice treatment for gout attacks. Be careful how much you use since it causes a lot of side effects.
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Reviews & ratings
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5.0476190476190474Allopurinol
Reviews for Zyloprim (Allopurinol)
71%
of people say Zyloprim (Allopurinol) is worth it
52%
say it works well
5%
say it's a big hassle

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Side effects
AllopurinolColcrys

The Allopurinol FDA package insert doesn’t have numbers about how common side effects are.

More about Allopurinol side effects »
  • Gastrointestinal disorders 6%
  • Gout 2%
  • Metabolic and nutrition disorders 1%
More Colcrys side effects »
How it works
AllopurinolColcrys
Zyloprim (Allopurinol) is a type of medicine called a xanthine oxidase inhibitor. It lowers uric acid levels in your blood, which prevents gout attacks and certain types of kidney stones.Colcrys (Colchicine) is a second choice antigout medication that prevents acute gout attacks by reducing inflammation.
Type of medication
AllopurinolColcrys
Antigout
Xanthine oxidase inhibitor
Prescription only
AntigoutPrescription only
Available as
AllopurinolColcrys
  • Pill
  • Pill
Used for (click to learn more)
AllopurinolColcrys
Risk factors for serious side effects
AllopurinolColcrys
          Detailed Zyloprim (Allopurinol) risks & warnings »
                Detailed Colcrys (Colchicine) risks & warnings »
                Pregnancy category
                AllopurinolColcrys
                CFDA pregnancy category (Weigh risks vs. benefits)

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                See the FDA package insert
                CFDA pregnancy category (Weigh risks vs. benefits)

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                See the FDA package insert
                Alcohol
                No specific alcohol-related info.No specific alcohol-related info.
                Food
                • Take with food or milk to prevent an upset stomach.
                • Take it with or without food.
                Kidneys and liver
                • You should drink a lot of fluids to prevent kidney stones from forming while taking this medication.
                • People who take Zyloprim (Allopurinol) can be more likely to have kidney stones, especially if you're dehydrated. Drink at least 10 to 12 eight ounce glasses of water every day to help prevent that from happening.
                • Doses needs to be adjusted if you have kidney or liver problems.
                • People on Colcrys (Colchicine) have reported muscle pain which can lead to muscle and kidney damage. This has been very rare. Talk to your doctor if you develop sudden muscle pain, weakness, or a fever and you don't know why.
                Sex
                No specific sex-related info.No specific sex-related info.
                Sleep
                No specific sleep-related info.No specific sleep-related info.
                Weight
                No specific weight-related info.No specific weight-related info.
                Upsides and benefits
                AllopurinolColcrys
                • Works well to lower the amount of uric acid in the body to reduce gout attacks.
                • Available as a generic medication.
                • Is an antigout medication that has anti-inflammatory properties to help treat sudden gout attacks.
                • Lowers the risk of sudden gout attacks when taken as prescribed to prevent gout attacks.
                • Also treats Familial Mediterranean Fever.
                Downsides and risks
                AllopurinolColcrys
                • Can actually increase the number of gout attacks in the first few weeks.
                • It can take 2 to 6 weeks to feel the full effects of the medication.
                • You should drink a lot of fluids to prevent kidney stones from forming while taking this medication.
                • Doesn't work as well as nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids to treat gout attacks.
                • Taking too much can cause serious side effects.
                • Doses needs to be adjusted if you have kidney or liver problems.
                • Doesn't have the ability to ease or treat pain.
                Tips from our pharmacists for people taking the medication
                AllopurinolColcrys
                • Drink plenty of water while taking this medication.
                • Take with food or milk to prevent an upset stomach.
                • It takes at least 2 to 6 weeks to experience the full benefit of this medication.
                • Your doctor can run blood tests to make sure the medication is working as it should.
                • Take it with or without food.
                • At the first sign of a gout attack, take two tablets. Don't take more than three tablets a day in order to avoid serious side effects.
                • Wait at least 3 days before another using Colcrys (Colchicine) again.
                • Almost all people experience some nausea, vomiting, or diarrhea after taking Colcrys (Colchicine).
                • Let your doctor know of any serious nausea, vomiting, diarrhea, or if you have tingling in your fingers or toes.
                Learn more
                More about AllopurinolSide effectsReviews & ratingsAlternativesFDA package insert
                More about ColcrysSide effectsReviews & ratingsAlternativesFDA package insert