Compare Allopurinol vs. Colcrys

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zyloprim
(allopurinol)

Colcrys
(colchicine)

Lowers uric acid levels in blood, and prevents gout flare-ups. Zyloprim (allopurinol) works well to prevent gout attacks and is cheaper than some alternatives, but it takes a few weeks to start working.Prevents and treats gout. Colcrys (colchicine) is a second-choice treatment for gout attacks. Be careful how much you use since it can cause problems with your blood.
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Prices and coupon for 30 (300mg) tablets of allopurinol
Coupons for
Prices and coupon for 30 (0.6mg) capsules of colchicine
Reviews & ratings
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Have you used Zyloprim (allopurinol)?
Worth itNot sureNot worth it

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Have you used Colcrys (colchicine)?
Worth itNot sureNot worth it
Side effects
AllopurinolColcrys

The Allopurinol FDA package insert doesn’t have numbers about how common side effects are.

More about Allopurinol side effects »
  • Stomach problems 6%
  • Diarrhea 9%
  • Gout 2%
  • Throat pain 3%
More Colcrys side effects »
How it works
AllopurinolColcrys
Zyloprim (allopurinol) is a xanthine oxidase inhibitor. It lowers uric acid levels in your blood, which can stop gout attacks and kidney stones.Colcrys (colchicine) stops the redness and swelling in gout attacks by blocking the cells that cause inflammation from going to the affected joints.
Type of medication
AllopurinolColcrys
Prescription only
Prescription only
Available as
AllopurinolColcrys
  • Pill
  • Injection
  • Pill
Used for
AllopurinolColcrys
Risk factors for serious side effects
AllopurinolColcrys
    • History of kidney stones
        • Taking other medications that also cause sleepiness
        • Recreational drug use
        • Excessive alcohol use
        • Elderly
        Detailed Zyloprim (allopurinol) risks & warnings »
            • Grapefruit
            • Grapefruit juice
            • Protease inhibitors
            • Antifungal antibiotics
            • Calcium channel blockers
            • Cyclosporine
            • Anti-cholesterol medicines
            • Digoxin
            • Kidney problems
            • Elderly
            • Use of statins or cholesterol medications
            • Use of cyclosporine
            Detailed Colcrys (colchicine) risks & warnings »
            Pregnancy

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            Interactions
            AllopurinolColcrys
            No interactions related info.
            • Many foods and medicines can interact with Colcrys (colchicine), which can be dangerous. If you have liver or kidney problems, these interactions can be worse. Talk to your doctor and pharmacist to see what dose of Colcrys (colchicine) you should take based on your diet and other medicines.
            Food
            AllopurinolColcrys
            • Take with food or milk to prevent an upset stomach.
            • Take Colcrys (colchicine) with or without food.
            • Many foods and medicines can interact with Colcrys (colchicine), which can be dangerous. If you have liver or kidney problems, these interactions can be worse. Talk to your doctor and pharmacist to see what dose of Colcrys (colchicine) you should take based on your diet and other medicines.
            Kidneys and liver
            AllopurinolColcrys
            • Kidney stones can form while taking Zyloprim (allopurinol), so you need to drink a lot of fluids to help prevent this.
            • Doses needs to be changed if you have kidney or liver problems.
            • Many foods and medicines can interact with Colcrys (colchicine), which can be dangerous. If you have liver or kidney problems, these interactions can be worse. Talk to your doctor and pharmacist to see what dose of Colcrys (colchicine) you should take based on your diet and other medicines.
            Sleep
            AllopurinolColcrys
            • Taking Zyloprim (allopurinol) can make you feel sleepy or dizzy, especially if you're taking other medicines that can also make you feel sleepy, or if you're taking recreational drugs or drinking too much alcohol. Avoid driving or doing other tasks that require concentration until you know how this medication affects you. Get up very slowly from a seated or lying down position.
            No sleep related info.
            Upsides and benefits
            AllopurinolColcrys
            • Zyloprim (allopurinol) works well to lower uric acid in the body.
            • It is available as a generic medication.
            • Colcrys (colchicine) treats and stops sudden gout attacks.
            • It can be used to prevent gout when people are first starting on allopurinol.
            • Colcrys (colchicine) also treats Familial Mediterranean fever.
            Downsides and risks
            AllopurinolColcrys
            • Zyloprim (allopurinol) can raise the number of gout attacks in the first few weeks.
            • It can take 2 to 6 weeks to feel the full effects of Zyloprim (allopurinol).
            • Kidney stones can form while taking Zyloprim (allopurinol), so you need to drink a lot of fluids to help prevent this.
            • Colcrys (colchicine) doesn't work as well as nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids to treat gout attacks.
            • Taking Colcrys (colchicine) for too long can cause problems with your blood.
            • Doses needs to be changed if you have kidney or liver problems.
            • While Colcrys (colchicine) stops the redness and swelling of gout attacks, it doesn't stop the pain.
            • If you're taking Colcrys (colchicine) to stop gout flare-ups, you can only use it for 3 to 6 months after your levels have stabilized.
            • The capsules (Mitigare) are only approved for prevention, but not treatment of gout.
            Tips from our pharmacists for people taking the medication
            AllopurinolColcrys
            • Drink plenty of water while taking Zyloprim (allopurinol).
            • Take with food or milk to prevent an upset stomach.
            • It takes at least 2 to 6 weeks to experience the full benefit of this medicine.
            • Your doctor can run blood tests to make sure the medication is working as it should.
            • During the first few weeks of starting this, you may need to be on a second anti-gout medicine to prevent flare-ups because Zyloprim (allopurinol) can cause gout attacks when you first start it.
            • If you're taking this because you have cancer, your doctor might have to change the doses of some of your chemotherapy drugs.
            • Take Colcrys (colchicine) with or without food.
            • At the first sign of a gout attack, take 2 tablets. Don't take more than 3 tablets a day in order to avoid serious side effects.
            • Wait at least 3 days before using Colcrys (colchicine) again, or at least 12 hours if you had been using Colcrys (colchicine) prophylactically.
            • Almost all people experience some nausea, vomiting, or diarrhea after taking Colcrys (colchicine).
            • Let your doctor know of any serious nausea, vomiting, diarrhea, or if you have tingling in your fingers or toes.
            • Avoid grapefruit and grapefruit juice while taking Colcrys (colchicine).
            Learn more
            More about AllopurinolSide effectsReviews & ratingsAlternativesFDA package insert
            Have you used Zyloprim (allopurinol)?
            Worth itNot sureNot worth it
            More about ColcrysSide effectsReviews & ratingsAlternativesFDA package insert
            Have you used Colcrys (colchicine)?
            Worth itNot sureNot worth it