Compare almotriptan vs. Cafergot

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Axert
(almotriptan)

Cafergot
(ergotamine / caffeine)

Treats migraine headaches. Axert (almotriptan) is better than other similar medications for migraines for pain relief.Treats migraine headaches. Cafergot (ergotamine / caffeine) can treat migraines, but you're more likely to have side effects.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for almotriptan
Best available price for 12 (12 tablets of 12.5mg) dose packs of almotriptan
Coupons for Cafergot
Best available price for 30 (1mg/100mg) tablets of cafergot
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Axert (almotriptan)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Cafergot (ergotamine / caffeine)?
Worth itNot sureNot worth it
Side effects
almotriptanCafergot
  • Nausea 1%
  • Sleepiness 3%
  • Dizziness 1%
  • Headache 1%
  • Vomiting 2%
More almotriptan side effects »

The Cafergot FDA package insert doesn’t have numbers about how common side effects are.

More about Cafergot side effects »
How it works
almotriptanCafergot
Axert (almotriptan) is a selective serotonin receptor agonist called a triptan. Migraine headaches happen when blood vessels are too open and allow too much blood in the brain. Axert (almotriptan) tightens the blood vessels which relieves the pain.Cafergot (ergotamine / caffeine) is a combination of ergotamine and caffeine. It tightens the blood vessels in your brain to relieve the pain of your headaches.
Type of medication
almotriptanCafergot
Prescription onlyPrescription only
Available as
almotriptanCafergot
  • Pill
  • Pill
  • Suppository
Used for
almotriptanCafergot
Risk factors for serious side effects
almotriptanCafergot
  • Heart disease
  • history of chest pain/angina
  • uncontrolled high blood pressure
  • History of a stroke
  • Using Axert (almotriptan) for more than 10 days a month
Detailed Axert (almotriptan) risks & warnings »
  • Overdosing Cafergot (ergotamine / caffeine)
  • Taking triptans (Imitrex, Axert, Maxalt, Amerge, Frova) for migraines
  • Taking Cafergot (ergotamine / caffeine) regularly for months
Detailed Cafergot (ergotamine / caffeine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Food
almotriptanCafergot
  • You can take Axert (almotriptan) with or without food.
No food related info.
Pain
almotriptanCafergot
  • Effective at relieving migraine pain.
No pain related info.
Upsides and benefits
almotriptanCafergot
  • Effective at relieving migraine pain.
  • You can take Axert (almotriptan) with or without food.
  • Axert (almotriptan) works within 30 minutes of taking it, and most people don't have to take a second dose to control their pain.
  • Axert (almotriptan) is available in generic.
  • Cafergot (ergotamine / caffeine) works better than other medicines if your migraines usually last more than 2 days or if you have more frequent migraines.
Downsides and risks
almotriptanCafergot
  • Axert (almotriptan) can only treat migraines that have already started. It can't stop a migraine from happening.
  • Axert (almotriptan) is only available as a pill that must be swallowed, so taking it might be difficult for someone who has trouble swallowing during a migraine.
  • Cafergot (ergotamine / caffeine) can't stop migraines from happening. They can only treat them.
  • Cafergot (ergotamine / caffeine) can only be used for migraines. It doesn't work for other types of headaches.
  • Smoking or using products that contain nicotine can make Cafergot (ergotamine / caffeine) less effective.
Tips from our pharmacists for people taking the medication
almotriptanCafergot
  • Axert (almotriptan) can only treat a migraine that's already happening. Axert (almotriptan) doesn't stop migraines from starting.
  • Take Axert (almotriptan) at the first sign of a migraine. You can take another dose if you don't feel better after 2 hours. Don't take more than two doses every 24 hours.
  • Axert (almotriptan) can make you feel dizzy or tired when you first start taking it. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • If you finish the entire month's supply of Axert (almotriptan) before your next refill or if you have more than 4 migraines a month, talk to your doctor to see if you should try something else.
  • Axert (almotriptan) can cause nausea or tightness in the chest or throat. Talk to your doctor if it bothers you.
  • Take Cafergot (ergotamine / caffeine) as soon as you feel the migraine coming on.
  • You might be more sensitive to cold when you take Cafergot (ergotamine / caffeine) since it slows down the circulation of your blood in your skin, fingers and toes. Dress warmly.
  • If you have to take more than 6 tablets or 2 suppositories a day or 10 tablets or 5 suppositories in a week of Cafergot (ergotamine / caffeine), talk to your doctor.
  • Don't smoke tobacco if you're taking Cafergot (ergotamine / caffeine).
  • Keep the suppository of Cafergot (ergotamine / caffeine) in the fridge.
Learn more
More about almotriptanSide effectsAlternativesFDA package insert
Have you used Axert (almotriptan)?
Worth itNot sureNot worth it
More about CafergotSide effectsAlternativesFDA package insert
Have you used Cafergot (ergotamine / caffeine)?
Worth itNot sureNot worth it