Compare almotriptan vs. Imitrex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Axert
(almotriptan)

Imitrex
(sumatriptan)

Treats migraine headaches. Axert (almotriptan) is better than other similar medications for migraines for pain relief.Treats migraine headaches. Imitrex (Sumatriptan) is an excellent choice for acute migraine relief, but you might need another medication to prevent headaches.
Reviews & ratings
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Have you used Axert (almotriptan)?
Worth itNot sureNot worth it
Reviews for Imitrex
74%
-74% worse vs. almotriptan
68%
-68% worse vs. almotriptan
19%
+19% better vs. almotriptan
Have you used Imitrex (sumatriptan)?
Worth itNot sureNot worth it
Side effects
almotriptanImitrex
  • Nausea 1%
  • Sleepiness 3%
  • Dizziness 1%
  • Headache 1%
  • Vomiting 2%
More almotriptan side effects »
  • Pain and other pressure sensations 2%
  • Atypical sensations 1%
  • Paresthesia (all types) 1%
  • Sensation warm/cold 1%
  • Pain - location specified 1%
  • Malaise/fatigue 2%
  • Chest - pain/tightness/pressure and/or heaviness 1%
  • Neck/throat/jaw - pain/ tightness/pressure 2%
  • Other - pressure/tightness/ heaviness 1%
  • Vertigo 2%
More Imitrex side effects »
How it works
almotriptanImitrex
Axert (almotriptan) is a selective serotonin receptor agonist called a triptan. Migraine headaches happen when blood vessels are too open and allow too much blood in the brain. Axert (almotriptan) tightens the blood vessels which relieves the pain.Imitrex (Sumatriptan) is a triptan medication that treats migraine headaches. It releases serotonin, which lowers the inflammation that causes headaches.
Type of medication
almotriptanImitrex
Prescription onlyPrescription only
Available as
almotriptanImitrex
  • Pill
  • Pill
  • Injection
  • Nasal spray
Used for
almotriptanImitrex
Risk factors for serious side effects
almotriptanImitrex
  • Heart disease
  • history of chest pain/angina
  • uncontrolled high blood pressure
  • History of a stroke
  • Using Axert (almotriptan) for more than 10 days a month
Detailed Axert (almotriptan) risks & warnings »
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
Detailed Imitrex (sumatriptan) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
almotriptanImitrex
  • You can take Axert (almotriptan) with or without food.
No food related info.
Pain
almotriptanImitrex
  • Effective at relieving migraine pain.
No pain related info.
Sleep
almotriptanImitrex
No sleep related info.
  • Imitrex (Sumatriptan) can make you drowsy, so avoid activities that need you to be fully alert until you know how it affects you.
Upsides and benefits
almotriptanImitrex
  • Effective at relieving migraine pain.
  • You can take Axert (almotriptan) with or without food.
  • Axert (almotriptan) works within 30 minutes of taking it, and most people don't have to take a second dose to control their pain.
  • Axert (almotriptan) is available in generic.
  • Comes in several forms. Ask your doctor if you should use the pill, nasal spray, patch, or injection.
  • A combination of forms can be used if symptoms do not improve.
  • The nasal spray and injectable forms work very quickly.
  • It's generally safe to use if you are pregnant.
  • Comes in a generic form, so it can be pretty cheap.
Downsides and risks
almotriptanImitrex
  • Axert (almotriptan) can only treat migraines that have already started. It can't stop a migraine from happening.
  • Axert (almotriptan) is only available as a pill that must be swallowed, so taking it might be difficult for someone who has trouble swallowing during a migraine.
  • The oral and nasal versions of Imitrex (Sumatriptan) have an unpleasant after-taste.
  • Does not prevent migraine headaches; it only treats them once they start.
  • Must wait 1 hour before using second injection.
  • Can cause rebound (more) headaches if Imitrex (Sumatriptan) is used too often.
  • Need to have your blood pressure checked often, especially if you're pregnant.
Tips from our pharmacists for people taking the medication
almotriptanImitrex
  • Axert (almotriptan) can only treat a migraine that's already happening. Axert (almotriptan) doesn't stop migraines from starting.
  • Take Axert (almotriptan) at the first sign of a migraine. You can take another dose if you don't feel better after 2 hours. Don't take more than two doses every 24 hours.
  • Axert (almotriptan) can make you feel dizzy or tired when you first start taking it. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • If you finish the entire month's supply of Axert (almotriptan) before your next refill or if you have more than 4 migraines a month, talk to your doctor to see if you should try something else.
  • Axert (almotriptan) can cause nausea or tightness in the chest or throat. Talk to your doctor if it bothers you.
  • Take it as soon as your headache starts.
  • If you use the nasal spray, be sure to blow your nose before using it.
  • If you use the patch, put it on a dry area free of scars, tattoos, or other cuts and scrapes. Be sure to press the button to activate it.
  • If you use the injection, you can use a second injection if you still have a headache after an hour. If you have symptoms 2 hours after the injection, switch to the pill version.
  • Imitrex (Sumatriptan) can make you drowsy, so avoid activities that need you to be fully alert until you know how it affects you.
  • Lie down in a dark room after taking Imitrex (Sumatriptan) to help ease the pain.
Learn more
More about almotriptanSide effectsAlternativesFDA package insert
Have you used Axert (almotriptan)?
Worth itNot sureNot worth it
More about ImitrexSide effectsReviews & ratingsFDA package insert
Have you used Imitrex (sumatriptan)?
Worth itNot sureNot worth it