Compare Alora vs. Estradiol Norethindrone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Alora
(estradiol patch)

Activella
(estradiol / norethindrone)

Relieves hot flashes and vaginal dryness due to menopause and strengthens your bones. Alora (estradiol patch) treats symptoms from low estrogen, and it may have fewer side effects than oral estrogen pills.Relieves menopause symptoms and lowers your risk of osteoporosis. Activella (Estradiol / Norethindrone) is effective at treating symptoms related to menopause and preventing bone loss. The estrogen/progestin combo is a good options for women with an intact uterus.
Reviews & ratings
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Have you used Alora (estradiol patch)?
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Have you used Activella (estradiol / norethindrone)?
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Side effects
AloraEstradiol Norethindrone
  • Breast pain 7%
  • Heartburn 8%
  • Stomach pain 3%
  • Weakness 3%
More Alora side effects »
  • Breast Pain 24%
  • Upper Respiratory Tract Infection 18%
  • Headache 16%
  • Sinusitis 7%
  • Insomnia 6%
  • Back Pain 6%
  • Post-Menopausal Bleeding 5%
  • Uterine Fibroid 5%
  • Infection Viral 4%
  • Moniliasis Genital 4%
More Estradiol Norethindrone side effects »
How it works
AloraEstradiol Norethindrone
Alora (estradiol patch) replaces an estrogen hormone that your body loses during and after menopause. Higher levels of the hormone relieve symptoms of low estrogen, menopause, and prevent bone loss.Activella (Estradiol / Norethindrone) contains two hormones that work to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats and prevents bone loss, but can also harm cells in the uterus after menopause. Norethindrone (a progestin) protects the uterus from damage.
Type of medication
AloraEstradiol Norethindrone
Prescription onlyPrescription only
Available as
AloraEstradiol Norethindrone
  • Patch
  • Pill
Used for
AloraEstradiol Norethindrone
  • Treats Hot Flashes Night Sweats And Flushing In Women In Menopause
  • Hot Flashes And Night Sweats
Risk factors for serious side effects
AloraEstradiol Norethindrone
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Personal or family history of blood clots
  • Smoking
Detailed Alora (estradiol patch) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
Detailed Activella (estradiol / norethindrone) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Weight
AloraEstradiol Norethindrone
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Activella (Estradiol / Norethindrone) is a mixture of estrogen and progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
Upsides and benefits
AloraEstradiol Norethindrone
  • Alora (estradiol patch) replaces estrogen to your whole body and relieves many symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • The patch is good for people who don't want to or can't take daily pills.
  • Can be worn while swimming, bathing, and showering.
  • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
  • Lowers your risk of fractures by keeping your bones healthy.
  • Activella (Estradiol / Norethindrone) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Good choice for women with intact uterus. The norethindrone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Mimvey brand is less expensive than other estrogen/progestin combination medicines.
Downsides and risks
AloraEstradiol Norethindrone
  • You need to replace Alora (estradiol patch) twice a week, compared to other patches that are once a week.
  • Patches can fall off.
  • Increases your risk of uterine and breast cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Can't be used in people with liver problems.
  • More potential side effects since it exposes your whole body to two hormones, estrogen and norethindrone (a progestin).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
Tips from our pharmacists for people taking the medication
AloraEstradiol Norethindrone
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin below your belly button on areas as instructed by the manufacturer (never on your breast).
  • Replace the patch twice a week (every 3-4 days) on a different area of the skin to lower the risk of skin irritation.
  • Fold together the sticky sides of used patches before throwing them away to prevent exposing others to the medicine. Don't flush them down the toilet.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
Learn more
More about AloraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Alora (estradiol patch)?
Worth itNot sureNot worth it
More about Estradiol NorethindroneSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Activella (estradiol / norethindrone)?
Worth itNot sureNot worth it