Compare Alora vs. Estradiol Norethindrone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Relieves hot flashes and vaginal dryness due to menopause and strengthens your bones.

Alora (estradiol patch) treats symptoms from low estrogen, and it may have fewer side effects than oral estrogen pills.

Relieves menopause symptoms and lowers your risk of osteoporosis.

Activella (Estradiol / Norethindrone) is effective at treating symptoms related to menopause and preventing bone loss. The estrogen/progestin combo is a good options for women with an intact uterus.

Upsides
  • Alora (estradiol patch) replaces estrogen to your whole body and relieves many symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • The patch is good for people who don't want to or can't take daily pills.
  • Can be worn while swimming, bathing, and showering.
  • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
  • Lowers your risk of fractures by keeping your bones healthy.
  • Activella (Estradiol / Norethindrone) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Good choice for women with intact uterus. The norethindrone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Mimvey brand is less expensive than other estrogen/progestin combination medicines.
Downsides
  • You need to replace Alora (estradiol patch) twice a week, compared to other patches that are once a week.
  • Patches can fall off.
  • Increases your risk of uterine and breast cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Can't be used in people with liver problems.
  • More potential side effects since it exposes your whole body to two hormones, estrogen and norethindrone (a progestin).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
Used for
  • Treats hot flashes, night sweats and flushing in women in menopause
  • Treats vaginal changes in women in menopause
  • Treats low estrogen in women
  • Prevents bone thinning in women in menopause
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Prevention of postmenopausal osteoporosis
Dosage forms
  • Patch
  • Pill
Price
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Reviews
Not enough review data.Leave a review
Not enough review data.Leave a review
Side effects
31possible side effects
  • Vaginal bleeding
    33%
  • Headache
    21%
  • Lung infection
    16%
  • Pain
    9%
  • Sinus infection
    8%
  • Vaginal inflammation
    8%
  • Breast pain
    7%
  • Back pain
    6%
  • Skin irritation
    6%
  • Accidental injury
    5%
  • Gas
    5%
  • Trouble sleeping
    5%
  • Itchiness
    5%
  • Nausea
    4%
  • Flu like symptoms
    3%
  • Stomach pain
    3%
  • Diarrhea
    3%
  • Depression
    3%
  • Airway inflammation
    3%
  • Cough
    3%
  • Rash
    3%
  • Weakness
    2%
  • Constipation
    2%
  • Swelling of arms and legs
    2%
  • Muscle aches
    2%
  • Anxiety
    2%
  • Sore throat
    2%
  • Breast growth
    2%
  • Bladder infection
    2%
  • White or yellow vaginal discharge
    2%
  • Breast tumor
    2%
See more detailed side effects
15possible side effects
  • Breast Pain
    24%
  • Upper Respiratory Tract Infection
    18%
  • Headache
    16%
  • Sinusitis
    7%
  • Back Pain
    6%
  • Insomnia
    6%
  • Post-Menopausal Bleeding
    5%
  • Uterine Fibroid
    5%
  • Infection Viral
    4%
  • Moniliasis Genital
    4%
  • Injury Accidental
    4%
  • Nausea
    3%
  • Ovarian Cyst
    3%
  • Gastroenteritis
    2%
  • Other Events
    2%
See more detailed side effects
Risks and risk factors
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Duration of use
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Harm to fetus
    • Women of childbearing age
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
  • Ovarian cancer
    • Family history of ovarian cancer
See more detailed risks and warnings