Compare Amaryl vs. Byetta

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Amaryl
(glimepiride)

Byetta
(exenatide)

Lowers your blood sugar. Amaryl (Glimepiride) is an effective blood sugar lowering medicine, but you have to avoid direct sunlight and alcohol.Lowers blood sugar. Byetta (Exenatide) can lower your blood sugars in addition to metformin. It does not increase your appetite unlike some other anti-diabetics, but must be given by injection and usually causes upset stomach.
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Coupons for Amaryl
Best available price for 60 (4mg) tablets of glimepiride
Coupons for Byetta
Best available price for 2.4 (10mcg) pens of byetta
Reviews & ratings
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Have you used Amaryl (glimepiride)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Byetta (exenatide)?
Worth itNot sureNot worth it
Side effects
AmarylByetta
  • Low blood sugar 17%
  • Accidental injury 3%
  • Nausea 2%
  • Dizziness 3%
More Amaryl side effects »
  • Low blood sugar 11%
  • Nausea 33%
  • Diarrhea 10%
  • Vomiting 14%
  • Headache 10%
  • Constipation 8%
  • Indigestion 5%
  • Weakness 4%
  • Abdominal swelling 3%
  • Loss of appetite 3%
More Byetta side effects »
How it works
AmarylByetta
Amaryl (Glimepiride) is an anti-diabetic medication. It causes your body to release more insulin.Byetta (Exenatide) enhances the release of insulin in your gut and pancreas to lower your blood sugar.
Type of medication
AmarylByetta
Prescription onlyPrescription only
Available as
AmarylByetta
  • Pill
  • Injection
Used for
AmarylByetta
Risk factors for serious side effects
AmarylByetta
  • Skipping meals or inconsistent meal times
  • Drinking alcohol
  • Using other diabetes medications and insulin
  • Autonomic neuropathy
  • Gastroparesis
Detailed Amaryl (glimepiride) risks & warnings »
  • Severe renal impairment
  • End-stage renal disease
  • Severe gastrointestinal disease
  • Gastroparesis
Detailed Byetta (exenatide) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
AmarylByetta
  • Avoid alcohol when taking Amaryl (Glimepiride).
No alcohol related info.
Food
AmarylByetta
  • Eat regular, balanced meals to avoid low blood sugar.
No food related info.
Kidneys and liver
AmarylByetta
No kidneys and liver related info.
  • If you have severe kidney or liver problems, you should not take Byetta (Exenatide). Talk to your doctor about testing your kidneys before starting Byetta (Exenatide). People taking medications that are damaging to kidneys such as ACE inhibitors, NSAIDs or diuretics in addition to Byetta (Exenatide) may notice nausea, vomiting, or diarrhea.
Pain
AmarylByetta
No pain related info.
  • Using Byetta (Exenatide) has been associated with stomach pain, nausea, vomiting and diarrhea. If you have severe gastrointestinal disease such as Crohn’s Disease or Ulcerative Colitis, you should talk to your doctor about using a different medicine for diabetes. You should not use Byetta (Exenatide) if you have gastroparesis, a condition that causes slow or irregular digestion. Gastroparesis can be common for people that have had uncontrolled diabetes for a while.
Weight
AmarylByetta
  • Can cause weight gain.
No weight related info.
Upsides and benefits
AmarylByetta
  • Has a lower chance of causing low blood sugar than glyburide.
  • Can be taken by mouth instead of getting an injection.
  • Lowers A1c levels by 1-2% (A1c measures your average blood sugar over time.)
  • Prevents the harmful effects of high sugar levels on your organs.
  • Also available as a generic medication, so its cheaper than many other diabetes medications.
  • Can lower your A1c (average blood sugar over time) by 1%.
  • Not as likely to cause very low blood sugar as glyburine or insulin.
  • Does not increase your appetite like other anti-diabetic medicines.
  • Pen is dialed to a single dose for easy injections.
Downsides and risks
AmarylByetta
  • Can cause weight gain.
  • You need to check your blood sugar 2 to 5 times per week.
  • Not preferred for people 65 years or older because it can cause episodes of low blood sugar.
  • Amaryl (Glimepiride) can cause a higher sensitivity to light so you may sunburn more easily.
  • Loses effectiveness over time as your body stops making insulin.
  • Byetta (Exenatide) must be injected twice a day. Other medicines like it can be injected once daily or even weekly.
  • It commonly causes nausea, vomiting, diarrhea, constipation, or indigestion.
  • Can affect how well your antibiotics and birth control pills work. Take them no sooner than one hour after your injections.
Tips from our pharmacists for people taking the medication
AmarylByetta
  • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
  • Eat regular, balanced meals to avoid low blood sugar.
  • Avoid direct sunlight while taking this medication and when you can’t avoid it, be sure to wear a long-sleeved shirt and pants, a hat, and sunglasses.
  • Avoid alcohol when taking Amaryl (Glimepiride).
  • It's best to check your blood sugar at least once a day using a home blood sugar monitor to make sure your medication is working and is safe. Some people may need to test more often.
  • Inject into your belly, thighs, or upper arms within an hour of your main meals.
  • Store unused pens in the refrigerator.
  • After first use, pens can be kept at room temperature for 30 days.
  • Change the needle and prime the pen every time you inject.
  • If you're also on insulin, don't inject into the same site.
  • Best to check your blood sugar once a day to make sure your medicine is working properly.
Learn more
More about AmarylSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Amaryl (glimepiride)?
Worth itNot sureNot worth it
More about ByettaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Byetta (exenatide)?
Worth itNot sureNot worth it