Compare Amaryl vs. Janumet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Amaryl (glimepiride)

Prescription only
Lowers blood sugar.

Amaryl (glimepiride) is an effective medicine for lowering blood sugar, but it can cause weight gain.

Lowers your blood sugar.

Janumet is a combination of two anti-diabetic medicines that work better together, but is available as brand only.

4.5/ 7 average rating with 79 reviewsforJanumet
Upsides
  • Needs to be taken only once a day.
  • Effectively lowers blood sugar and A1c levels by 1-2%. (A1c is a test that measures your average blood sugars over the past 3 months).
  • Amaryl (glimepiride) is an oral medicine so it might be a good alternative for those who don't like injections.
  • Protects your organs and blood vessels by preventing the harmful effects of high blood sugar levels.
  • Available as a generic form and is relatively cheap.
  • This 2-in-1 combination can lower the number of pills you have to take daily.
  • Lowers A1c (average blood sugar over time) up to 2.5%.
  • Available in extended and immediate release forms to allow better control of your blood sugar.
  • Doesn't increase your appetite unlike other anti-diabetic medicines.
  • Does not cause hypoglycemia or very low blood sugar.
Downsides
  • Amaryl (glimepiride) might cause weight gain.
  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • Not preferred for people age 65 or older because they are at higher risk of experiencing side effects such as low blood sugar.
  • Might lose its effectiveness over time.
  • Needs to be taken 30 minutes before a meal for it to be most effective.
  • Available as brand name only and may be expensive.
  • Metformin component usually causes upset stomach.
  • Sitagliptin component may increase your risk for throat infections and inflammation of pancreas.
  • Not appropriate for those with poor kidney function.
Used for
Dosage forms
  • Pill
  • Pill
  • Extended release
Price
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$10
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$415.3
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Reviews
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79 
46%
think this treatment is worth it
38%
think this treatment works well
15%
think this treatment is a hassle

Have you used Janumet (sitagliptin / metformin)?

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Side effects
5possible side effects
  • Headache
    8%
  • Accidental injury
    6%
  • Flu syndrome
    5%
  • Nausea
    5%
  • Dizziness
    5%
See more detailed side effects
The Janumet (sitagliptin / metformin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Low blood sugar

    Skipping meals or having inconsistent meal times

    ...and 4 more risk factors

  • Severe allergic reaction

    History of allergy to sulfa-containing medicine

  • Breakdown of red blood cells

    People with G6PD deficiency

  • Kidney and liver disease

    Those with kidney and/or liver disease

See more detailed risks and warnings
  • Excess lactic acid in the blood

    Kidney problems

    ...and 5 more risk factors

See more detailed risks and warnings