Compare Amaryl vs. Janumet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Amaryl
(glimepiride)

Janumet
(sitagliptin / metformin)

Lowers your blood sugar. Amaryl (Glimepiride) is an effective blood sugar lowering medicine, but you have to avoid direct sunlight and alcohol.Lowers your blood sugar. Janumet is a combination of two anti-diabetic medicines that work better together, but is available as brand only.
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Coupons for Amaryl
Best available price for 60 (4mg) tablets of glimepiride
Coupons for Janumet
Best available price for 60 (50mg/1000mg) tablets of janumet
Reviews & ratings
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Have you used Amaryl (glimepiride)?
Worth itNot sureNot worth it
Reviews for Janumet
46%
+4% better vs. Amaryl
38%
+62% better vs. Amaryl
15%
-35% worse vs. Amaryl
Have you used Janumet (sitagliptin / metformin)?
Worth itNot sureNot worth it
Side effects
AmarylJanumet
  • Low blood sugar 17%
  • Accidental injury 3%
  • Nausea 2%
  • Dizziness 3%
More Amaryl side effects »
  • Low blood sugar 15%
  • Diarrhea 4%
  • Ear, nose, or throat infection 1%
  • Headache 3%
More Janumet side effects »
How it works
AmarylJanumet
Amaryl (Glimepiride) is an anti-diabetic medication. It causes your body to release more insulin.Janumet (sitagliptin / metformin) is a combination of two anti-diabetic medicines. Metformin lowers the amount of sugar your body produces, and sitagliptin enhances the release of insulin.
Type of medication
AmarylJanumet
Prescription onlyPrescription only
Available as
AmarylJanumet
  • Pill
  • Pill
  • Extended release
Used for
AmarylJanumet
Risk factors for serious side effects
AmarylJanumet
  • Skipping meals or inconsistent meal times
  • Drinking alcohol
  • Using other diabetes medications and insulin
  • Autonomic neuropathy
  • Gastroparesis
Detailed Amaryl (glimepiride) risks & warnings »
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Using contrast dye for procedures
  • Surgery
Detailed Janumet (sitagliptin / metformin) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
AmarylJanumet
  • Avoid alcohol when taking Amaryl (Glimepiride).
No alcohol related info.
Food
AmarylJanumet
  • Eat regular, balanced meals to avoid low blood sugar.
  • Take with food to avoid upset stomach with diarrhea, nausea, and vomiting.
Kidneys and liver
AmarylJanumet
No kidneys and liver related info.
  • Not appropriate for those with poor kidney function.
Weight
AmarylJanumet
  • Can cause weight gain.
No weight related info.
Upsides and benefits
AmarylJanumet
  • Has a lower chance of causing low blood sugar than glyburide.
  • Can be taken by mouth instead of getting an injection.
  • Lowers A1c levels by 1-2% (A1c measures your average blood sugar over time.)
  • Prevents the harmful effects of high sugar levels on your organs.
  • Also available as a generic medication, so its cheaper than many other diabetes medications.
  • This 2-in-1 combination can lower the number of pills you have to take daily.
  • Lowers A1c (average blood sugar over time) up to 2.5%.
  • Available in extended and immediate release forms to allow better control of your blood sugar.
  • Doesn't increase your appetite unlike other anti-diabetic medicines.
  • Does not cause hypoglycemia or very low blood sugar.
Downsides and risks
AmarylJanumet
  • Can cause weight gain.
  • You need to check your blood sugar 2 to 5 times per week.
  • Not preferred for people 65 years or older because it can cause episodes of low blood sugar.
  • Amaryl (Glimepiride) can cause a higher sensitivity to light so you may sunburn more easily.
  • Loses effectiveness over time as your body stops making insulin.
  • Available as brand name only and may be expensive.
  • Metformin component usually causes upset stomach.
  • Sitagliptin component may increase your risk for throat infections and inflammation of pancreas.
  • Not appropriate for those with poor kidney function.
Tips from our pharmacists for people taking the medication
AmarylJanumet
  • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
  • Eat regular, balanced meals to avoid low blood sugar.
  • Avoid direct sunlight while taking this medication and when you can’t avoid it, be sure to wear a long-sleeved shirt and pants, a hat, and sunglasses.
  • Avoid alcohol when taking Amaryl (Glimepiride).
  • It's best to check your blood sugar at least once a day using a home blood sugar monitor to make sure your medication is working and is safe. Some people may need to test more often.
  • Take with food to avoid upset stomach with diarrhea, nausea, and vomiting.
  • May cause headaches and cold-like symptoms.
  • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
  • Can be expensive depending on insurance coverage.
  • Check your blood sugar regularly.
Learn more
More about AmarylSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Amaryl (glimepiride)?
Worth itNot sureNot worth it
More about JanumetSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Janumet (sitagliptin / metformin)?
Worth itNot sureNot worth it