Compare Amaryl vs. Januvia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Amaryl
(glimepiride)

Januvia
(sitagliptin)

Lowers your blood sugar. Amaryl (Glimepiride) is an effective blood sugar lowering medicine, but you have to avoid direct sunlight and alcohol.Lowers your blood sugar. Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine.
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Coupons for Amaryl
Best available price for 60 (4mg) tablets of glimepiride
Coupons for Januvia
Best available price for 30 (100mg) tablets of januvia
Reviews & ratings
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Have you used Amaryl (glimepiride)?
Worth itNot sureNot worth it
Reviews for Januvia
44%
+6% better vs. Amaryl
34%
+66% better vs. Amaryl
17%
-33% worse vs. Amaryl
143 reviews
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it
Side effects
AmarylJanuvia
  • Low blood sugar 17%
  • Accidental injury 3%
  • Nausea 2%
  • Dizziness 3%
More Amaryl side effects »
  • Common cold 2%
  • Diarrhea 1%
  • Upper respiratory infection 3%
  • Headache 1%
More Januvia side effects »
How it works
AmarylJanuvia
Amaryl (Glimepiride) is an anti-diabetic medication. It causes your body to release more insulin.Januvia (sitagliptin) is an anti-diabetic drug that enhances your body's release of insulin.
Type of medication
AmarylJanuvia
Prescription onlyPrescription only
Available as
AmarylJanuvia
  • Pill
  • Pill
Used for
AmarylJanuvia
Risk factors for serious side effects
AmarylJanuvia
  • Skipping meals or inconsistent meal times
  • Drinking alcohol
  • Using other diabetes medications and insulin
  • Autonomic neuropathy
  • Gastroparesis
Detailed Amaryl (glimepiride) risks & warnings »
  • History of pancreatitis
  • High blood triglyceride levels
  • Gallstones (stones in gallbladder)
  • History of alchoholism
  • Kidney problems
Detailed Januvia (sitagliptin) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
AmarylJanuvia
  • Avoid alcohol when taking Amaryl (Glimepiride).
No alcohol related info.
Food
AmarylJanuvia
  • Eat regular, balanced meals to avoid low blood sugar.
  • Take once a day in the morning with or without food.
Kidneys and liver
AmarylJanuvia
No kidneys and liver related info.
  • Januvia (sitagliptin) can worsen kidney problems. Your doctor may check your kidney function before and during treatment. Your doctor may have to adjust the dose or stop this medicine based on changes in kidney function.
Pain
AmarylJanuvia
No pain related info.
  • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
Weight
AmarylJanuvia
  • Can cause weight gain.
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
Upsides and benefits
AmarylJanuvia
  • Has a lower chance of causing low blood sugar than glyburide.
  • Can be taken by mouth instead of getting an injection.
  • Lowers A1c levels by 1-2% (A1c measures your average blood sugar over time.)
  • Prevents the harmful effects of high sugar levels on your organs.
  • Also available as a generic medication, so its cheaper than many other diabetes medications.
  • Oral blood sugar-lowering medicine.
  • Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class.
  • Uses the hormones naturally produced by your body to affect how sugar is processed.
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
Downsides and risks
AmarylJanuvia
  • Can cause weight gain.
  • You need to check your blood sugar 2 to 5 times per week.
  • Not preferred for people 65 years or older because it can cause episodes of low blood sugar.
  • Amaryl (Glimepiride) can cause a higher sensitivity to light so you may sunburn more easily.
  • Loses effectiveness over time as your body stops making insulin.
  • Lowers A1c (average blood sugar over time) by less than 1%.
  • Available as brand version only.
  • Some people might get frequent cold-like symptoms.
  • Rare but serious side effects include pancreatitis and severe joint pain.
Tips from our pharmacists for people taking the medication
AmarylJanuvia
  • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
  • Eat regular, balanced meals to avoid low blood sugar.
  • Avoid direct sunlight while taking this medication and when you can’t avoid it, be sure to wear a long-sleeved shirt and pants, a hat, and sunglasses.
  • Avoid alcohol when taking Amaryl (Glimepiride).
  • It's best to check your blood sugar at least once a day using a home blood sugar monitor to make sure your medication is working and is safe. Some people may need to test more often.
  • Take once a day in the morning with or without food.
  • Can cause headache and cold-like symptoms.
  • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
  • Tell your doctor right away if you are experiencing severe joint pain.
  • Check your blood sugar regularly to check for low blood sugar.
Learn more
More about AmarylSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Amaryl (glimepiride)?
Worth itNot sureNot worth it
More about JanuviaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it