Compare Amaryl vs. Januvia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Amaryl (glimepiride)

Prescription only

Januvia (sitagliptin)

Prescription only
Lowers blood sugar.

Amaryl (glimepiride) is an effective medicine for lowering blood sugar, but it can cause weight gain.

Lowers your blood sugar.

Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine.

4.3/ 7 average rating with 143 reviewsforJanuvia
Upsides
  • Needs to be taken only once a day.
  • Effectively lowers blood sugar and A1c levels by 1-2%. (A1c is a test that measures your average blood sugars over the past 3 months).
  • Amaryl (glimepiride) is an oral medicine so it might be a good alternative for those who don't like injections.
  • Protects your organs and blood vessels by preventing the harmful effects of high blood sugar levels.
  • Available as a generic form and is relatively cheap.
  • Oral blood sugar-lowering medicine.
  • Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class.
  • Uses the hormones naturally produced by your body to affect how sugar is processed.
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
Downsides
  • Amaryl (glimepiride) might cause weight gain.
  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • Not preferred for people age 65 or older because they are at higher risk of experiencing side effects such as low blood sugar.
  • Might lose its effectiveness over time.
  • Needs to be taken 30 minutes before a meal for it to be most effective.
  • Lowers A1c (average blood sugar over time) by less than 1%.
  • Available as brand version only.
  • Some people might get frequent cold-like symptoms.
  • Rare but serious side effects include pancreatitis and severe joint pain.
Used for
Dosage forms
  • Pill
  • Pill
Price
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$10
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Lowest price near you
$415.3
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Reviews
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143 
44%
think this treatment is worth it
34%
think this treatment works well
17%
think this treatment is a hassle

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Side effects
5possible side effects
  • Headache
    8%
  • Accidental injury
    6%
  • Flu syndrome
    5%
  • Nausea
    5%
  • Dizziness
    5%
See more detailed side effects
3possible side effects
  • Common cold
    5%
  • Diarrhea
    3%
  • Abdominal pain
    2%
See more detailed side effects
Risks and warnings
  • Low blood sugar

    Skipping meals or having inconsistent meal times

    ...and 4 more risk factors

  • Severe allergic reaction

    History of allergy to sulfa-containing medicine

  • Breakdown of red blood cells

    People with G6PD deficiency

  • Kidney and liver disease

    Those with kidney and/or liver disease

See more detailed risks and warnings
  • Death from inflammation of the pancreas (pancreatitis)

    History of pancreatitis

    ...and 4 more risk factors

  • Kidney damage

    Pre-existing kidney damage

  • Low blood sugar (hypoglycemia)

    Taking medicines for diabetes

See more detailed risks and warnings