Compare Amaryl vs. metformin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Amaryl
(glimepiride)

Glucophage
(metformin)

Lowers your blood sugar. Amaryl (Glimepiride) is an effective blood sugar lowering medicine, but you have to avoid direct sunlight and alcohol.Lowers blood sugar. Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects.
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Coupons for Amaryl
Best available price for 60 (4mg) tablets of glimepiride
Coupons for metformin
Best available price for 60 (500mg) tablets of metformin
Reviews & ratings
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Have you used Amaryl (glimepiride)?
Worth itNot sureNot worth it
Reviews for metformin
65%
-15% worse vs. Amaryl
46%
+54% better vs. Amaryl
16%
-34% worse vs. Amaryl
938 reviews
Have you used Glucophage (metformin)?
Worth itNot sureNot worth it
Side effects
Amarylmetformin
  • Low blood sugar 17%
  • Accidental injury 3%
  • Nausea 2%
  • Dizziness 3%
More Amaryl side effects »
  • Diarrhea 41%
  • Nausea/vomiting 18%
  • Gas 6%
  • Weakness 3%
  • Indigestion 3%
  • Stomach pain 1%
  • Headache 1%
More metformin side effects »
How it works
Amarylmetformin
Amaryl (Glimepiride) is an anti-diabetic medication. It causes your body to release more insulin.Glucophage (metformin) is an anti-diabetic drug. It lowers the amount of sugar your body makes or absorbs, and allows your body use the existing insulin better.
Type of medication
Amarylmetformin
Prescription onlyPrescription only
Available as
Amarylmetformin
  • Pill
  • Pill
  • Extended release pill
  • Liquid
Used for
Amarylmetformin
Risk factors for serious side effects
Amarylmetformin
  • Skipping meals or inconsistent meal times
  • Drinking alcohol
  • Using other diabetes medications and insulin
  • Autonomic neuropathy
  • Gastroparesis
Detailed Amaryl (glimepiride) risks & warnings »
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Using contrast dye for procedures
  • Surgery
Detailed Glucophage (metformin) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
Amarylmetformin
  • Avoid alcohol when taking Amaryl (Glimepiride).
  • Limit or avoid alcohol when taking this medicine.
  • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
Food
Amarylmetformin
  • Eat regular, balanced meals to avoid low blood sugar.
  • Always take it with food to lessen stomach upset.
Kidneys and liver
Amarylmetformin
No kidneys and liver related info.
  • Glucophage (metformin) can cause this rare life-threatening condition. Your doctor will check your kidneys and liver before you start. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. You're more likely to get this if you already have kidney problems. Glucophage (metformin) should be stopped 48 hours before and after surgery or any imaging procedure needing contrast dye.
  • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
Weight
Amarylmetformin
  • Can cause weight gain.
  • Doesn't cause weight gain.
Upsides and benefits
Amarylmetformin
  • Has a lower chance of causing low blood sugar than glyburide.
  • Can be taken by mouth instead of getting an injection.
  • Lowers A1c levels by 1-2% (A1c measures your average blood sugar over time.)
  • Prevents the harmful effects of high sugar levels on your organs.
  • Also available as a generic medication, so its cheaper than many other diabetes medications.
  • Improves sugar control and lowers A1c levels as much as 2%.
  • One of the few diabetes medicines that lowers the risk of death from diabetes-related complications.
  • Doesn't cause weight gain.
  • Rarely causes low blood sugar.
Downsides and risks
Amarylmetformin
  • Can cause weight gain.
  • You need to check your blood sugar 2 to 5 times per week.
  • Not preferred for people 65 years or older because it can cause episodes of low blood sugar.
  • Amaryl (Glimepiride) can cause a higher sensitivity to light so you may sunburn more easily.
  • Loses effectiveness over time as your body stops making insulin.
  • Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping.
  • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
  • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
Tips from our pharmacists for people taking the medication
Amarylmetformin
  • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
  • Eat regular, balanced meals to avoid low blood sugar.
  • Avoid direct sunlight while taking this medication and when you can’t avoid it, be sure to wear a long-sleeved shirt and pants, a hat, and sunglasses.
  • Avoid alcohol when taking Amaryl (Glimepiride).
  • It's best to check your blood sugar at least once a day using a home blood sugar monitor to make sure your medication is working and is safe. Some people may need to test more often.
  • Can cause upset stomach with nausea and especially diarrhea in the first couple of weeks.
  • Always take it with food to lessen stomach upset.
  • Stay hydrated.
  • Limit or avoid alcohol when taking this medicine.
  • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
  • Check your blood sugar regularly.
Learn more
More about AmarylSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Amaryl (glimepiride)?
Worth itNot sureNot worth it
More about metforminSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Glucophage (metformin)?
Worth itNot sureNot worth it