Compare Amaryl vs. metformin
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Amaryl (glimepiride) is an effective medicine for lowering blood sugar, but it can cause weight gain.
Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects.
- Needs to be taken only once a day.
- Effectively lowers blood sugar and A1c levels by 1-2%. (A1c is a test that measures your average blood sugars over the past 3 months).
- Amaryl (glimepiride) is an oral medicine so it might be a good alternative for those who don't like injections.
- Protects your organs and blood vessels by preventing the harmful effects of high blood sugar levels.
- Available as a generic form and is relatively cheap.
- Improves sugar control and lowers A1c levels as much as 2%.
- One of the few diabetes medicines that lowers the risk of death from diabetes-related complications.
- Doesn't cause weight gain.
- Rarely causes low blood sugar.
- Amaryl (glimepiride) might cause weight gain.
- Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
- Not preferred for people age 65 or older because they are at higher risk of experiencing side effects such as low blood sugar.
- Might lose its effectiveness over time.
- Needs to be taken 30 minutes before a meal for it to be most effective.
- Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping.
- Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
- Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
- Extended release pill
- Accidental injury6%
- Flu syndrome5%
- Stomach pain6%
- Low blood sugar
Skipping meals or having inconsistent meal times
...and 4 more risk factors
- Severe allergic reaction
History of allergy to sulfa-containing medicine
- Breakdown of red blood cells
People with G6PD deficiency
- Kidney and liver disease
Those with kidney and/or liver disease
- Excess lactic acid in the blood
...and 5 more risk factors