Compare Ambien vs. amoxapine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ambien (zolpidem)

Prescription only

Asendin (amoxapine)

Prescription only
Helps you sleep.

Ambien (zolpidem) aids in falling asleep and staying asleep, but it can be habit-forming and might be more likely than other sleep medicines to cause side effects.

3.7/ 5 average rating with 1375 reviewsforAmbien
Stabilizes your mood.

While Asendin (amoxapine) can treat depression, you have to take it several times a day and it can make you feel sleepy.

Upsides
  • Effective at helping people fall asleep faster and sleep longer.
  • Extended release form is particularly good for staying asleep, and you can use it for longer than the immediate release form.
  • Generic is available.
  • Asendin (amoxapine) can be used to treat more severe forms of depression.
  • Compared to similar medicines, Asendin (amoxapine) improves the mood in depression more quickly.
  • Asendin (amoxapine) is available as generic.
Downsides
  • Not typically used for long-term treatment because it can be habit-forming.
  • Some people find that Ambien (zolpidem) becomes less effective over time.
  • More likely to cause sleep-walking, sleep-driving, and sleep-eating.
  • Might not be safe if you have problems with your liver, kidneys, lungs, or if you have a history of depression.
  • Asendin (amoxapine) is not a first choice medicine for depression because of side effects.
  • In some people, Asendin (amoxapine) can stop working as early as 2-3 months after you start taking it.
  • Not recommended in older people, children under 16, or people who've had a history of seizures.
Used for
Dosage forms
  • Pill
  • Oral spray
  • Sublingual pill
  • Pill
Price
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Reviews
1375 reviews so far
67%
saidit'sworth it
50%
saiditworked well
16%
saidit'sa big hassle

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Side effects
18possible side effects
  • Drowsiness
    8%
  • Headache
    7%
  • Dizziness
    5%
  • Allergic reactions
    4%
  • Sinus infection
    4%
  • Dry mouth
    3%
  • Back pain
    3%
  • Lack of energy
    3%
  • Drugged feeling
    3%
  • Diarrhea
    3%
  • Sore throat
    3%
  • Flu-like symptoms
    2%
  • Racing heart
    2%
  • Lightheadedness
    2%
  • Depression
    2%
  • Abdominal pain
    2%
  • Constipation
    2%
  • Rash
    2%
See more detailed side effects
4possible side effects
  • Drowsiness or fatigue
    14%
  • Dry mouth
    14%
  • Constipation
    12%
  • Vision changes
    7%
See more detailed side effects
Risks and risk factors
  • Dependence and withdrawal
    • Continuous use of Ambien (zolpidem) for 2 weeks or more
  • Driving impairment
    • Alcohol
    • Taking other medications that make you less alert
    • Less than 8 hours of sleep.
  • Abnormal thoughts
    • Undiagnosed psychiatric conditions
  • Performing activities while asleep
    • Taking Ambien (zolpidem) with alcohol or drugs that cause drowsiness
  • Risk of falls and injury
    • Higher dose
    • Liver problems
    • Taking Ambien (zolpidem) with other nervous system depressants
    • Long-term use
    • Elderly (70 years or older)
See more detailed risks and warnings
  • Increased risk of suicide
    • People under age 24
  • Vision changes
    • Glaucoma
  • Difficulty controlling movements
  • Neuroleptic malignant syndrome
    • Taking antidepressants
  • Slowed breathing
    • Taking opioids for pain relief or medicines for anxiety
  • Anticholinergic effects/Dehydration
    • Over age 65
See more detailed risks and warnings