Compare Ambien vs. amoxapine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ambien
(zolpidem)

Asendin
(amoxapine)

Helps you sleep. Ambien (zolpidem) aids in falling asleep and staying asleep, but it can be habit-forming and might be more likely than other sleep medicines to cause side effects.Stabilizes your mood. While Asendin (amoxapine) can treat depression, you have to take it several times a day and it can make you feel sleepy.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.1Ambien
Reviews for Ambien
67%
of people (All ages) say Ambien is worth it
50%
say it works well
16%
say it's a big hassle
1375 reviews
Have you used Ambien (zolpidem)?
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Have you used Asendin (amoxapine)?
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Side effects
Ambienamoxapine
  • Drowsiness 3%
  • Headache 1%
  • Dizziness 4%
  • Allergic reactions 3%
  • Sinus infection 2%
  • Sore throat 2%
  • Dry mouth 2%
  • Lack of energy 2%
  • Back pain 1%
  • Diarrhea 1%
More Ambien side effects »
  • Drowsiness or fatigue 14%
  • Dry mouth 14%
  • Constipation 12%
  • Vision changes 7%
More amoxapine side effects »
How it works
Ambienamoxapine
Ambien (zolpidem) is in a class of drugs called sedative-hypnotics. It interacts with your brain to make you relaxed and sleepy.Asendin (amoxapine) is a tricyclic antidepressant. It increases the activity of serotonin and norepinephrine in your brain which regulate your mood.
Type of medication
Ambienamoxapine
Prescription onlyPrescription only
Available as
Ambienamoxapine
  • Pill
  • Oral spray
  • Sublingual pill
  • Pill
Used for
Ambienamoxapine
Risk factors for serious side effects
Ambienamoxapine
  • Continuous use of Ambien (zolpidem) for 2 weeks or more
  • Alcohol
  • Taking other medications that make you less alert
  • Less than 8 hours of sleep.
  • Undiagnosed psychiatric conditions
Detailed Ambien (zolpidem) risks & warnings »
  • People under age 24
  • Glaucoma
  • Taking antidepressants
  • Taking opioids for pain relief or medicines for anxiety
  • Over age 65
Detailed Asendin (amoxapine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
Ambienamoxapine
  • Avoid alcohol and drugs when taking Ambien (zolpidem).
No alcohol related info.
Food
Ambienamoxapine
No food related info.
  • Take Asendin (amoxapine) with food to avoid stomach upset.
Kidneys and liver
Ambienamoxapine
  • Might not be safe if you have problems with your liver, kidneys, lungs, or if you have a history of depression.
No kidneys and liver related info.
Sleep
Ambienamoxapine
  • Ambien (zolpidem) makes you feel drowsy and sleepy, potentially leading to falls and severe injuries. This is especially a risk if you're older. Falls from sleep medicines like Ambien (zolpidem) have caused severe injuries such as hip fractures and head injury. You may need a lower dose if you're taking other medications that also cause drowsiness. Check with your doctor first.
  • Only take it if you have time to sleep for at least 8 hours.
  • Effective at helping people fall asleep faster and sleep longer.
  • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
Upsides and benefits
Ambienamoxapine
  • Effective at helping people fall asleep faster and sleep longer.
  • Extended release form is particularly good for staying asleep, and you can use it for longer than the immediate release form.
  • Generic is available.
  • Asendin (amoxapine) can be used to treat more severe forms of depression.
  • Compared to similar medicines, Asendin (amoxapine) improves the mood in depression more quickly.
  • Asendin (amoxapine) is available as generic.
Downsides and risks
Ambienamoxapine
  • Not typically used for long-term treatment because it can be habit-forming.
  • Some people find that Ambien (zolpidem) becomes less effective over time.
  • More likely to cause sleep-walking, sleep-driving, and sleep-eating.
  • Might not be safe if you have problems with your liver, kidneys, lungs, or if you have a history of depression.
  • Asendin (amoxapine) is not a first choice medicine for depression because of side effects.
  • In some people, Asendin (amoxapine) can stop working as early as 2-3 months after you start taking it.
  • Not recommended in older people, children under 16, or people who've had a history of seizures.
Tips from our pharmacists for people taking the medication
Ambienamoxapine
  • Take 30 to 45 minutes before bedtime.
  • Only take it if you have time to sleep for at least 8 hours.
  • Can be addictive. Meant for short-term treatment. Dependence can form after daily use for 2 weeks.
  • Avoid alcohol and drugs when taking Ambien (zolpidem).
  • Withdrawal symptoms can occur if you abruptly stop the drug and you've been regularly using it. The symptoms usually resolve in 1 to 2 nights.
  • Report any confusion or changes in thoughts or behavior.
  • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • You might not notice any changes in your mood for at least a few weeks.
  • Take Asendin (amoxapine) with food to avoid stomach upset.
  • You're more likely to be dehydrated and constipated. Drink plenty of fluids and be careful not to get overheated if you're out in the sun.
  • Don't stop taking Asendin (amoxapine) without talking to your doctor. Stopping Asendin (amoxapine) suddenly can be very dangerous.
Learn more
More about AmbienSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Ambien (zolpidem)?
Worth itNot sureNot worth it
More about amoxapineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Asendin (amoxapine)?
Worth itNot sureNot worth it