Compare Ambien vs. Anafranil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ambien
(Zolpidem)

Anafranil
(Clomipramine)

Helps you sleep. Ambien (Zolpidem) is good for falling asleep and staying asleep, but it can be habit-forming and might be more likely than other sleep medicines to cause disturbing side effects.Helps with your actions. Anafranil (Clomipramine) is helpful in treating OCD, but it can have a lot of side effects.
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Reviews & ratings
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5.089219330855019Ambien
Reviews for Ambien (Zolpidem)
66%
of people say Ambien (Zolpidem) is worth it
50%
say it works well
16%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
AmbienAnafranil
  • Dizziness 4%
  • Drowsiness 3%
  • Allergy 3%
  • Sinus inflammation 2%
  • Dry mouth 2%
  • Sore throat 2%
  • Diarrhea 2%
  • Lack of energy 2%
  • Lightheadedness 1%
  • Low mood disorder 1%
More Ambien side effects »
  • Dry mouth 67%
  • Tremor 52%
  • Dizziness 40%
  • Ejaculation failure 40%
  • Drowsiness 38%
  • Constipation 36%
  • Increased sweating 26%
  • Fatigue 21%
  • Loss of appetite 20%
  • Nausea 19%
More Anafranil side effects »
How it works
AmbienAnafranil
Ambien (Zolpidem) is in a class of drugs called sedative-hypnotics. Researchers don't know exactly how it works, but it interacts with your brain to make you relaxed and sleepy.Anafranil (Clomipramine) is a tricyclic antidepressant (TCA). It treats obsessive-compulsive disorder by affecting the levels of serotonin and norepinephrine in your brain.
Type of medication
AmbienAnafranil
SedativePrescription only
Antidepressant
Tricyclic antidepressant (TCA)
Prescription only
Available as
AmbienAnafranil
  • Pill
  • Extended release
  • Pill
Used for (click to learn more)
AmbienAnafranil
Risk factors for serious side effects
AmbienAnafranil
  • Continuous use for 2 weeks or more
  • Alcohol
  • Taking other medicines that make you less alert
  • Less than 7 hours of sleep
  • Undiagnosed psychiatric conditions
  • Taking with alcohol or drugs
    • Respiratory conditions
    • Liver problems
    • Muscle disease
    • Elderly
    • Higher dose
    • Liver problems
    • Taking Ambien (Zolpidem) with other nervous system depressants
    • Long-term use
    • Women of childbearing age
    • Breast-feeding
    Detailed Ambien (Zolpidem) risks & warnings »
    • Age 24 years or younger
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Using other medications that affect serotonin
    • History of seizure
    • Taking other medicines that increase seizure risk
    • Alcoholism
    • Stopping Anafranil (Clomipramine) suddenly
    • Age 65 years or older
    • History of heart disease
    • Older age
    • Electrolyte imbalance
    Detailed Anafranil (Clomipramine) risks & warnings »
    Pregnancy category
    AmbienAnafranil
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    Alcohol
    • Avoid alcohol and drugs.
    • Ambien (Zolpidem) can be disinhibiting (like alcohol) or cause hallucinations. Tell your doctor if you notice any unusual changes in behavior.
    No specific alcohol-related info.
    Food
    • Works best if taken without food.
    • Take it with food and/or at bedtime to decrease the potential side effects.
    Kidneys and liver
    • Might not be safe if you have problems with your liver, kidneys, or lungs, or if you have a history of depression.
    No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.
    • Can cause sexual performance problems in men.
    Sleep
    • More likely to cause sleep-walking, sleep-driving, and sleep-eating.
    • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behavior so that you can sleep better naturally.
    • Effective at helping people fall asleep faster and sleep longer.
    • Only take it if you have time to sleep for at least 7 hours.
    • Can cause headache, drowsiness, and dizziness.
    • Can cause sleep-walking, sleep-driving, and sleep-eating.
    • All prescription sleep-aid medicines like Ambien (Zolpidem) have a risk of physical dependence. Dependence means that you'll feel withdrawal symptoms if you stop taking the medication all at once. Talk to your doctor about natural ways to improve sleep or treat underlying conditions that prevent sleep.
    • Ambien (Zolpidem) increases your risk of performing potentially dangerous activities while asleep, such as sleep-walking, sleep-driving, and sleep-eating. Talk to your doctor immediately about stopping Ambien (Zolpidem) if any sleep-related activities occur.
    • Ambien (Zolpidem) make you feel drowsy and sleepy, leading to falls and severe injuries. This is especially a risk if your older. Falls from sleep medicines like Ambien (Zolpidem) have caused severe injuries such as hip fractures and head injury. You may need a lower dose if you're taking other medicine that affects your nervous system or have issues with falls in the past. Check with your doctor first.
    • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
    • Can help you sleep.
    • Stopping Anafranil (Clomipramine) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and dizziness. Withdrawal symptoms usually occur within 3-5 days of stopping the medication, and go away within 1-2 weeks. Work with your doctor to gradually reduce your dose.
    Weight
    No specific weight-related info.
    • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
    Upsides and benefits
    AmbienAnafranil
    • Effective at helping people fall asleep faster and sleep longer.
    • Extended release form is particularly good for staying asleep, and you can use it for longer than the immediate release form.
    • Works well to decrease the symptoms of obsessive-compulsive disorder (OCD).
    • Helps some people see improvements in their mood.
    • Can help you sleep.
    • Lower risk of causing heart problems compared to other medicine in this class.
    Downsides and risks
    AmbienAnafranil
    • Not typically used for long-term treatment because it can be habit-forming.
    • Some people find that it's less effective over time.
    • More likely to cause sleep-walking, sleep-driving, and sleep-eating.
    • Might not be safe if you have problems with your liver, kidneys, or lungs, or if you have a history of depression.
    • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behavior so that you can sleep better naturally.
    • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
    • Can cause sexual performance problems in men.
    • Increases the risk of falls, especially when used in the elderly.
    Tips from our pharmacists for people taking the medication
    AmbienAnafranil
    • Take 30 to 45 minutes before bedtime.
    • Only take it if you have time to sleep for at least 7 hours.
    • Very addictive. Meant for short-term treatment. Dependence can form after daily use for 2 weeks.
    • Can cause headache, drowsiness, and dizziness.
    • Can cause sleep-walking, sleep-driving, and sleep-eating.
    • Works best if taken without food.
    • Avoid alcohol and drugs.
    • Withdrawal symptoms usually resolve in 1 to 2 nights.
    • Report any confusion or changes in thoughts or behavior.
    • Needs to be taken every day for 2 to 3 weeks to see the full effect of the medication.
    • It's important to keep taking Anafranil (Clomipramine) even when you feel your symptoms are getting better.
    • Take it with food and/or at bedtime to decrease the potential side effects.
    • Tell your doctor if you notice sudden mood changes or unusual thoughts.
    • If you decide to stop taking Anafranil (Clomipramine), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
    Learn more
    More about AmbienSide effectsReviews & ratingsAlternativesFDA package insert
    More about AnafranilSide effectsReviews & ratingsAlternativesFDA package insert