Compare Ambien vs. Anafranil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ambien
(zolpidem)

Anafranil
(clomipramine)

Helps you sleep. Ambien (zolpidem) aids in falling asleep and staying asleep, but it can be habit-forming and might be more likely than other sleep medicines to cause side effects.Helps with your actions. Anafranil (Clomipramine) is helpful in treating OCD, but it can have a lot of side effects.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.1Ambien
Reviews for Ambien
67%
of people (All ages) say Ambien is worth it
50%
say it works well
16%
say it's a big hassle
1375 reviews
Have you used Ambien (zolpidem)?
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Have you used Anafranil (clomipramine)?
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Side effects
AmbienAnafranil
  • Drowsiness 3%
  • Headache 1%
  • Dizziness 4%
  • Allergic reactions 3%
  • Sinus infection 2%
  • Sore throat 2%
  • Dry mouth 2%
  • Lack of energy 2%
  • Back pain 1%
  • Diarrhea 1%
More Ambien side effects »
  • Dry mouth 67%
  • Tremor 52%
  • Dizziness 40%
  • Somnolence 38%
  • Headache 11%
  • Constipation 36%
  • Ejaculation failure 40%
  • Fatigue 21%
More Anafranil side effects »
How it works
AmbienAnafranil
Ambien (zolpidem) is in a class of drugs called sedative-hypnotics. It interacts with your brain to make you relaxed and sleepy.Anafranil (Clomipramine) is a tricyclic antidepressant (TCA). It treats obsessive-compulsive disorder by affecting the levels of serotonin and norepinephrine in your brain.
Type of medication
AmbienAnafranil
Prescription onlyPrescription only
Available as
AmbienAnafranil
  • Pill
  • Oral spray
  • Sublingual pill
  • Pill
Used for
AmbienAnafranil
Risk factors for serious side effects
AmbienAnafranil
  • Continuous use of Ambien (zolpidem) for 2 weeks or more
  • Alcohol
  • Taking other medications that make you less alert
  • Less than 8 hours of sleep.
  • Undiagnosed psychiatric conditions
Detailed Ambien (zolpidem) risks & warnings »
  • Age 24 years or younger
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Using other medications that affect serotonin
  • History of seizure
Detailed Anafranil (clomipramine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
AmbienAnafranil
  • Avoid alcohol and drugs when taking Ambien (zolpidem).
No alcohol related info.
Food
AmbienAnafranil
No food related info.
  • Take it with food and/or at bedtime to decrease the potential side effects.
Kidneys and liver
AmbienAnafranil
  • Might not be safe if you have problems with your liver, kidneys, lungs, or if you have a history of depression.
No kidneys and liver related info.
Sleep
AmbienAnafranil
  • Ambien (zolpidem) makes you feel drowsy and sleepy, potentially leading to falls and severe injuries. This is especially a risk if you're older. Falls from sleep medicines like Ambien (zolpidem) have caused severe injuries such as hip fractures and head injury. You may need a lower dose if you're taking other medications that also cause drowsiness. Check with your doctor first.
  • Only take it if you have time to sleep for at least 8 hours.
  • Effective at helping people fall asleep faster and sleep longer.
  • Can help you sleep.
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
Upsides and benefits
AmbienAnafranil
  • Effective at helping people fall asleep faster and sleep longer.
  • Extended release form is particularly good for staying asleep, and you can use it for longer than the immediate release form.
  • Generic is available.
  • Works well to decrease the symptoms of obsessive-compulsive disorder (OCD).
  • Helps some people see improvements in their mood.
  • Can help you sleep.
  • Lower risk of causing heart problems compared to other medicine in this class.
Downsides and risks
AmbienAnafranil
  • Not typically used for long-term treatment because it can be habit-forming.
  • Some people find that Ambien (zolpidem) becomes less effective over time.
  • More likely to cause sleep-walking, sleep-driving, and sleep-eating.
  • Might not be safe if you have problems with your liver, kidneys, lungs, or if you have a history of depression.
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
  • Can cause sexual performance problems in men.
  • Increases the risk of falls, especially when used in the elderly.
Tips from our pharmacists for people taking the medication
AmbienAnafranil
  • Take 30 to 45 minutes before bedtime.
  • Only take it if you have time to sleep for at least 8 hours.
  • Can be addictive. Meant for short-term treatment. Dependence can form after daily use for 2 weeks.
  • Avoid alcohol and drugs when taking Ambien (zolpidem).
  • Withdrawal symptoms can occur if you abruptly stop the drug and you've been regularly using it. The symptoms usually resolve in 1 to 2 nights.
  • Report any confusion or changes in thoughts or behavior.
  • Needs to be taken every day for 2 to 3 weeks to see the full effect of the medication.
  • It's important to keep taking Anafranil (Clomipramine) even when you feel your symptoms are getting better.
  • Take it with food and/or at bedtime to decrease the potential side effects.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • If you decide to stop taking Anafranil (Clomipramine), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
Learn more
More about AmbienSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Ambien (zolpidem)?
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More about AnafranilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Anafranil (clomipramine)?
Worth itNot sureNot worth it