Compare Ambien vs. Lunesta

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ambien (zolpidem)

Prescription only

Lunesta (Eszopiclone)

Prescription only
Helps you sleep.

Ambien (zolpidem) aids in falling asleep and staying asleep, but it can be habit-forming and might be more likely than other sleep medicines to cause side effects.

5.1/ 7 average rating with 1375 reviewsforAmbien
Helps you sleep.

Lunesta (Eszopiclone) is good for falling asleep and staying asleep. Not as habit-forming as some sleep medicines, but more likely to cause withdrawal symptoms if you stop suddenly.

4.5/ 7 average rating with 592 reviewsforLunesta
Upsides
  • Effective at helping people fall asleep faster and sleep longer.
  • Extended release form is particularly good for staying asleep, and you can use it for longer than the immediate release form.
  • Generic is available.
  • Effective at helping people fall asleep faster and sleep longer.
  • Not as habit-forming, so you can use it for longer than most other sleep medicines.
Downsides
  • Not typically used for long-term treatment because it can be habit-forming.
  • Some people find that Ambien (zolpidem) becomes less effective over time.
  • More likely to cause sleep-walking, sleep-driving, and sleep-eating.
  • Might not be safe if you have problems with your liver, kidneys, lungs, or if you have a history of depression.
  • More likely to cause withdrawal symptoms if you stop taking it suddenly.
  • Might not be safe if you have a history of drug or alcohol abuse, depression, lung disease, or a condition that affects metabolism.
  • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behavior so that you can sleep better naturally.
Used for
Dosage forms
  • Pill
  • Oral spray
  • Sublingual pill
  • Pill
Price
Lowest price near you
$8.49
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Lowest price near you
$22.82
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Reviews
1375 
67%
think this treatment is worth it
50%
think this treatment works well
16%
think this treatment is a hassle

Have you used Ambien (zolpidem)?

Leave a review
592 
55%
think this treatment is worth it
36%
think this treatment works well
17%
think this treatment is a hassle

Have you used Lunesta (Eszopiclone)?

Leave a review
Side effects
10possible side effects
  • Drowsiness
    8%
  • Headache
    7%
  • Dizziness
    5%
  • Allergic reactions
    4%
  • Sinus infection
    4%
  • Dry mouth
    3%
  • Back pain
    3%
  • Lack of energy
    3%
  • Drugged feeling
    3%
  • Diarrhea
    3%
See more detailed side effects
10possible side effects
  • Headache
    15%
  • Unpleasant Taste
    8%
  • Dyspepsia
    6%
  • Pain
    4%
  • Diarrhea
    4%
  • Pruritus
    4%
  • Dry Mouth
    3%
  • Abnormal Dreams
    3%
  • Neuralgia
    3%
  • Urinary Tract Infection
    3%
See more detailed side effects
Risks and warnings
  • Dependence and withdrawal

    Continuous use of Ambien (zolpidem) for 2 weeks or more

  • Driving impairment

    Alcohol

    ...and 2 more risk factors

  • Abnormal thoughts

    Undiagnosed psychiatric conditions

  • Performing activities while asleep

    Taking Ambien (zolpidem) with alcohol or drugs that cause drowsiness

  • Risk of falls and injury

    Higher dose

    ...and 4 more risk factors

See more detailed risks and warnings
  • Dependence and withdrawal

    Continuous use for 2 weeks or more

  • Driving impairment

    Alcohol

    ...and 2 more risk factors

  • Abnormal thoughts

    Undiagnosed psychiatric conditions

  • Sleep driving

    Taking with alcohol or drugs that acts in the brain

  • Risk of falls and injury

    Elderly

    ...and 4 more risk factors

  • Risk to fetus

    Women of childbearing age

    ...and 1 more risk factors

See more detailed risks and warnings