Compare Ambien vs. Remeron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ambien
(zolpidem)

Remeron
(mirtazapine)

Helps you sleep. Ambien (zolpidem) aids in falling asleep and staying asleep, but it can be habit-forming and might be more likely than other sleep medicines to cause side effects.Improves mood. Remeron (mirtazapine) improves your mood and helps you sleep better, but can cause more weight gain than any other antidepressant.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.1Ambien
Reviews for Ambien
67%
of people (All ages) say Ambien is worth it
50%
say it works well
16%
say it's a big hassle
1375 reviews
Have you used Ambien (zolpidem)?
Worth itNot sureNot worth it
Reviews for Remeron
45%
+22% better vs. Ambien
39%
+11% better vs. Ambien
26%
+10% better vs. Ambien
152 reviews
Have you used Remeron (mirtazapine)?
Worth itNot sureNot worth it
Side effects
AmbienRemeron
  • Drowsiness 2%
  • Flu-like symptoms 2%
  • Racing heart 2%
  • Lightheadedness 1%
  • Depression 1%
  • Constipation 1%
  • Rash 1%
  • Dry mouth 2%
  • Back pain 1%
More Ambien side effects »
  • Back pain 1%
  • Swelling in limbs 1%
  • Muscle pain 1%
  • Tremor 1%
  • Confusion 2%
  • Urinary frequency 1%
  • Abnormal thinking 2%
  • Abnormal dreams 3%
  • Flu syndrome 2%
  • Dizziness 4%
More Remeron side effects »
How it works
AmbienRemeron
Ambien (zolpidem) is in a class of drugs called sedative-hypnotics. It interacts with your brain to make you relaxed and sleepy.Remeron (mirtazapine) is an atypical antidepressant. It stimulates your body to make certain chemicals in the brain, such as serotonin and norepinephrine, which regulate mood.
Type of medication
AmbienRemeron
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic available
Available as
AmbienRemeron
  • Pill
  • Oral spray
  • Sublingual pill
  • Pill
  • Dissolving tablet
Used for
AmbienRemeron
Risk factors for serious side effects
AmbienRemeron
  • Continuous use of Ambien (zolpidem) for 2 weeks or more
  • Alcohol
  • Taking other medications that make you less alert
  • Less than 8 hours of sleep.
  • Undiagnosed psychiatric conditions
Detailed Ambien (zolpidem) risks & warnings »
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • History of heart problems
  • History of liver problems
  • Higher dose
Detailed Remeron (mirtazapine) risks & warnings »
Pregnancy
Interactions
AmbienRemeron
No interactions related info.
  • Prescription medications can interact with Remeron (mirtazapine). Let your doctor or pharmacist know if you're on prescription medications currently or within the past 14 days.
Alcohol
AmbienRemeron
  • Avoid alcohol and drugs when taking Ambien (zolpidem).
No alcohol related info.
Kidneys and liver
AmbienRemeron
  • Might not be safe if you have problems with your liver, kidneys, lungs, or if you have a history of depression.
No kidneys and liver related info.
Sleep
AmbienRemeron
  • Ambien (zolpidem) makes you feel drowsy and sleepy, potentially leading to falls and severe injuries. This is especially a risk if you're older. Falls from sleep medicines like Ambien (zolpidem) have caused severe injuries such as hip fractures and head injury. You may need a lower dose if you're taking other medications that also cause drowsiness. Check with your doctor first.
  • Only take it if you have time to sleep for at least 8 hours.
  • Effective at helping people fall asleep faster and sleep longer.
  • Remeron (mirtazapine) can make you sleepy. It is best to take at bedtime.
  • Can help you fall asleep if you have trouble sleeping.
  • Makes you more tired than other antidepressants.
Weight
AmbienRemeron
No weight related info.
  • Remeron (mirtazapine) can raise your appetite and cause you to gain weight. Remeron (mirtazapine) can also raise your cholesterol.
  • Remeron (mirtazapine) can increase your appetite and cause to you to gain weight.
  • Good option if you are underweight or frail, because it can help you gain weight.
  • More likely to cause minor weight gain (1-5 pounds) and raise cholesterol than any other antidepressant.
Upsides and benefits
AmbienRemeron
  • Effective at helping people fall asleep faster and sleep longer.
  • Extended release form is particularly good for staying asleep, and you can use it for longer than the immediate release form.
  • Generic is available.
  • Effective at relieving some depression symptoms.
  • Starts to work more quickly than most antidepressants.
  • Can help you fall asleep if you have trouble sleeping.
  • Can also help relieve anxiety.
  • Good option if you are underweight or frail, because it can help you gain weight.
  • Available as a generic.
Downsides and risks
AmbienRemeron
  • Not typically used for long-term treatment because it can be habit-forming.
  • Some people find that Ambien (zolpidem) becomes less effective over time.
  • More likely to cause sleep-walking, sleep-driving, and sleep-eating.
  • Might not be safe if you have problems with your liver, kidneys, lungs, or if you have a history of depression.
  • Makes you more tired than other antidepressants.
  • More likely to cause minor weight gain (1-5 pounds) and raise cholesterol than any other antidepressant.
Tips from our pharmacists for people taking the medication
AmbienRemeron
  • Take 30 to 45 minutes before bedtime.
  • Only take it if you have time to sleep for at least 8 hours.
  • Can be addictive. Meant for short-term treatment. Dependence can form after daily use for 2 weeks.
  • Avoid alcohol and drugs when taking Ambien (zolpidem).
  • Withdrawal symptoms can occur if you abruptly stop the drug and you've been regularly using it. The symptoms usually resolve in 1 to 2 nights.
  • Report any confusion or changes in thoughts or behavior.
  • Remeron (mirtazapine) can make you sleepy. It is best to take at bedtime.
  • Remeron (mirtazapine) can increase your appetite and cause to you to gain weight.
  • You should not abruptly stop Remeron (mirtazapine) as this could cause serious side effects.
  • Prescription medications can interact with Remeron (mirtazapine). Let your doctor or pharmacist know if you're on prescription medications currently or within the past 14 days.
  • Remeron (mirtazapine) should be protected from light. Keep it in it's original package until ready to use.
  • Remeron (mirtazapine) can cause dry mouth. Try using sugar-free gum or candy to help with dry mouth.
Learn more
More about AmbienSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Ambien (zolpidem)?
Worth itNot sureNot worth it
More about RemeronSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Remeron (mirtazapine)?
Worth itNot sureNot worth it