Compare Ambien vs. Remeron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ambien
(Zolpidem)

Remeron
(Mirtazapine)

Helps you sleep. Ambien (Zolpidem) is good for falling asleep and staying asleep, but it can be habit-forming and might be more likely than other sleep medicines to cause disturbing side effects.Improves mood. Remeron (Mirtazapine) is okay for treating depression and good for sleep. More likely to cause weight gain than any other antidepressant.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.1Ambien
Reviews for Ambien (Zolpidem)
67%
of people (All ages) say Ambien (Zolpidem) is worth it
50%
say it works well
16%
say it's a big hassle
1375 reviews
Have you used Ambien (Zolpidem)?
Worth itNot sureNot worth it
Reviews for Remeron (Mirtazapine)
45%
-22% worse vs. Ambien (Zolpidem)
39%
-11% worse vs. Ambien (Zolpidem)
26%
-10% worse vs. Ambien (Zolpidem)
152 reviews
Have you used Remeron (Mirtazapine)?
Worth itNot sureNot worth it
Side effects
AmbienRemeron
  • Drowsiness 3%
  • Dizziness 4%
  • Sinus inflammation 2%
  • Allergy 3%
  • Drugged feeling 3%
  • Back pain 1%
  • Sore throat 2%
  • Lack of energy 2%
  • Dry mouth 2%
  • Diarrhea 1%
More Ambien side effects »
  • Drowsiness 36%
  • Dry mouth 10%
  • Increased appetite 15%
  • Constipation 6%
  • Weight gain 10%
  • Muscle weakness 3%
  • Dizziness 4%
  • Flu syndrome 2%
  • Abnormal dreams 3%
  • Thinking abnormal 2%
More Remeron side effects »
How it works
AmbienRemeron
Ambien (Zolpidem) is in a class of drugs called sedative-hypnotics. Researchers don't know exactly how it works, but it interacts with your brain to make you relaxed and sleepy.Remeron (Mirtazapine) is an atypical antidepressant. It stimulates your body to make certain chemicals in the brain, such as serotonin and norepinephrine, which regulate mood.
Type of medication
AmbienRemeron
Prescription only
Prescription only
Available as
AmbienRemeron
  • Pill
  • Extended release
  • Pill
  • Dissolving tablet
Used for
AmbienRemeron
Risk factors for serious side effects
AmbienRemeron
  • Continuous use for 2 weeks or more
  • Alcohol
  • Taking other medicines that make you less alert
  • Less than 7 hours of sleep
  • Undiagnosed psychiatric conditions
  • Taking with alcohol or drugs
    • Respiratory conditions
    • Liver problems
    • Muscle disease
    • Elderly
    • Higher dose
    • Liver problems
    • Taking Ambien (Zolpidem) with other nervous system depressants
    • Long-term use
    • Women of childbearing age
    • Breast-feeding
    Detailed Ambien (Zolpidem) risks & warnings »
    • Age 24 years or younger
    • Using other medications that affect serotonin
    • History of heart problems
    • History of liver problems
    • Higher dose
    • Alcohol
    • Taking other medicines that make you less alert
        Detailed Remeron (Mirtazapine) risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Alcohol
        AmbienRemeron
        • Avoid alcohol and drugs.
        No alcohol related info.
        Kidneys and liver
        AmbienRemeron
        • Might not be safe if you have problems with your liver, kidneys, or lungs, or if you have a history of depression.
        No kidneys and liver related info.
        Sleep
        AmbienRemeron
        • Effective at helping people fall asleep faster and sleep longer.
        • Only take it if you have time to sleep for at least 7 hours.
        • Can cause headache, drowsiness, and dizziness.
        • Ambien (Zolpidem) make you feel drowsy and sleepy, leading to falls and severe injuries. This is especially a risk if your older. Falls from sleep medicines like Ambien (Zolpidem) have caused severe injuries such as hip fractures and head injury. You may need a lower dose if you're taking other medicine that affects your nervous system or have issues with falls in the past. Check with your doctor first.
        No sleep related info.
        Weight
        AmbienRemeron
        No weight related info.
        • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
        • Can increase appetite and weight.
        • Remeron (Mirtazapine) can increase appetite and cause you to gain weight.
        Upsides and benefits
        AmbienRemeron
        • Effective at helping people fall asleep faster and sleep longer.
        • Extended release form is particularly good for staying asleep, and you can use it for longer than the immediate release form.
        • Effective at relieving some depression symptoms.
        • Starts to work more quickly than most antidepressants.
        • Might be a good option for people who have insomnia with their depression, because it can make you very sleepy.
        • Good option for people who are underweight or frail, because it can help you gain weight.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        Downsides and risks
        AmbienRemeron
        • Not typically used for long-term treatment because it can be habit-forming.
        • Some people find that it's less effective over time.
        • More likely to cause sleep-walking, sleep-driving, and sleep-eating.
        • Might not be safe if you have problems with your liver, kidneys, or lungs, or if you have a history of depression.
        • It's easy to become reliant on sleep medicines. In the long run, it's better to learn good sleeping habits and behavior so that you can sleep better naturally.
        • Not as effective as other medications for depression.
        • More sedating than other antidepressants.
        • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
        • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        Tips from our pharmacists for people taking the medication
        AmbienRemeron
        • Take 30 to 45 minutes before bedtime.
        • Only take it if you have time to sleep for at least 7 hours.
        • Very addictive. Meant for short-term treatment. Dependence can form after daily use for 2 weeks.
        • Can cause headache, drowsiness, and dizziness.
        • Can cause sleep-walking, sleep-driving, and sleep-eating.
        • Works best if taken without food.
        • Avoid alcohol and drugs.
        • Withdrawal symptoms usually resolve in 1 to 2 nights.
        • Report any confusion or changes in thoughts or behavior.
        • Makes you sleepy. Take at bedtime.
        • Can increase appetite and weight.
        • Takes 8 to 12 weeks to see full effects on mood.
        • Stop taking slowly to avoid withdrawal symptoms.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        Learn more
        More about AmbienSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Ambien (Zolpidem)?
        Worth itNot sureNot worth it
        More about RemeronSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Remeron (Mirtazapine)?
        Worth itNot sureNot worth it