Compare Ambien vs. Unisom

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ambien (zolpidem)

Prescription only
Helps you sleep.

Ambien (zolpidem) aids in falling asleep and staying asleep, but it can be habit-forming and might be more likely than other sleep medicines to cause side effects.

3.7/ 5 average rating with 1375 reviewsforAmbien
Treats allergy symptoms and helps you sleep.

Unisom Sleeptabs (Doxylamine) can help you get a good night's sleep, but you can have a hard time waking up if you don't give yourself enough time to sleep.

3.3/ 5 average rating with 585 reviewsforUnisom
Upsides
  • Effective at helping people fall asleep faster and sleep longer.
  • Extended release form is particularly good for staying asleep, and you can use it for longer than the immediate release form.
  • Generic is available.
  • Works well to help you fall asleep and doesn't make you feel groggy the next morning.
  • Has fewer side effects than prescription sleep aid medications.
  • Available over the counter without a prescription.
  • Not habit-forming like other sleep aids can be.
Downsides
  • Not typically used for long-term treatment because it can be habit-forming.
  • Some people find that Ambien (zolpidem) becomes less effective over time.
  • More likely to cause sleep-walking, sleep-driving, and sleep-eating.
  • Might not be safe if you have problems with your liver, kidneys, lungs, or if you have a history of depression.
  • Shouldn't be used unless you have a full night to sleep.
  • You shouldn't drive after taking Unisom Sleeptabs (Doxylamine) until you know how it affects you.
  • Drinking alcohol while taking Unisom Sleeptabs (Doxylamine) isn't recommended.
  • It can increase the risk of falls, so elderly people shouldn't use Unisom Sleeptabs (Doxylamine).
Used for
Dosage forms
  • Pill
  • Oral spray
  • Sublingual pill
  • Pill
  • Chewable tablet
  • Liquid
Price
No pricing information available
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Reviews
1375 reviews so far
67%
saidit'sworth it
50%
saiditworked well
16%
saidit'sa big hassle

Have you used Ambien (zolpidem)?

Leave a review
585 reviews so far
58%
saidit'sworth it
32%
saiditworked well
11%
saidit'sa big hassle

Have you used Unisom Sleeptabs (Doxylamine)?

Leave a review
Side effects
18possible side effects
  • Drowsiness
    8%
  • Headache
    7%
  • Dizziness
    5%
  • Allergic reactions
    4%
  • Sinus infection
    4%
  • Dry mouth
    3%
  • Back pain
    3%
  • Lack of energy
    3%
  • Drugged feeling
    3%
  • Diarrhea
    3%
  • Sore throat
    3%
  • Flu-like symptoms
    2%
  • Racing heart
    2%
  • Lightheadedness
    2%
  • Depression
    2%
  • Abdominal pain
    2%
  • Constipation
    2%
  • Rash
    2%
See more detailed side effects
The Unisom Sleeptabs (Doxylamine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Dependence and withdrawal
    • Continuous use of Ambien (zolpidem) for 2 weeks or more
  • Driving impairment
    • Alcohol
    • Taking other medications that make you less alert
    • Less than 8 hours of sleep.
  • Abnormal thoughts
    • Undiagnosed psychiatric conditions
  • Performing activities while asleep
    • Taking Ambien (zolpidem) with alcohol or drugs that cause drowsiness
  • Risk of falls and injury
    • Higher dose
    • Liver problems
    • Taking Ambien (zolpidem) with other nervous system depressants
    • Long-term use
    • Elderly (70 years or older)
See more detailed risks and warnings
  • Overdosage
    • Using other drugs with similar ingredients
  • Increased side effects
    • Age 65 years or older
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Hyperactivity
    • Children age 6 years or younger
  • Trouble urinating
    • Enlarged prostate
    • History of bladder problems
  • Vision changes
    • Glaucoma
  • Breastfeeding
    • Nursing mothers
See more detailed risks and warnings