Compare Amerge vs. Onzetra

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Amerge (naratriptan)

Prescription only

Onzetra (sumatriptan)

Prescription only
Treats migraine headaches.

Amerge (naratriptan) isn't as good as other similar medications for migraines, but can be good if other drugs haven't worked for you.

Treats migraine headaches.

Onzetra (sumatriptan) is the only medicine that's available in a breath-powered nose powder to treat migraines. However, it can be expensive compared to other medicines.

Upsides
  • Amerge (naratriptan) is a good alternative to other triptans since it's less likely to cause side effects and if other triptans haven't worked for you.
  • Available as a generic, which makes it cheaper than other medicines and is more likely to be covered by insurances.
  • Amerge (naratriptan) comes in two different strengths.
  • Compared to pills, Onzetra (sumatriptan) is better absorbed in the body and good if it's hard to take pills.
  • Onzetra (sumatriptan) is a first choice medicine to treat migraines.
  • There is a copay program available that can make Onzetra (sumatriptan) cheaper.
Downsides
  • Amerge (naratriptan) is only available as a pill that must be swallowed, so it might not be good if you have trouble swallowing when you have a migraine.
  • Unlike other migraine medications, you have to wait for 4 hours before you can take the second dose of Amerge (naratriptan).
  • Amerge (naratriptan) is not as good as other medications for treating nausea that can happen with migraines.
  • It can be very expensive. There are other forms of this same medicine that are much cheaper, including a nose spray.
  • You have to use two nosepieces to get the full dose of Onzetra (sumatriptan), which can be hard to remember.
  • Onzetra (sumatriptan) is only available in one strength.
Used for
Dosage forms
  • Pill
  • Nasal powder
Price
Lowest price near you
$26.03
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Lowest price near you
$12.4
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Reviews
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Side effects
6possible side effects
  • Stomach problems
    6%
  • Nausea
    4%
  • Nervous system issues
    4%
  • Unusual sensation
    2%
  • Fatigue or uneasiness
    2%
  • Pain and pressure sensation
    2%
See more detailed side effects
4possible side effects
  • Changes in taste
    20%
  • Discomfort in the nose
    11%
  • Runny nose
    5%
  • Stuffy nose
    2%
See more detailed side effects
Risks and warnings
  • Heart attack

    Heart disease

    ...and 2 more risk factors

  • Stroke

    History of a stroke

  • Medication overuse headache

    Using Amerge (naratriptan) for more than 10 days a month

  • Serotonin syndrome

    Tricyclic antidepressants

    ...and 5 more risk factors

  • Increased blood pressure

    Uncontrolled high blood pressure

  • Blood vessel issues

    High blood pressure

    ...and 2 more risk factors

See more detailed risks and warnings
  • Heart attack

    Heart disease

    ...and 2 more risk factors

  • Stroke

    History of a stroke

  • Medication overuse headache

    Using Onzetra (sumatriptan) for more than 10 days a month

  • Serotonin syndrome

    Tricyclic antidepressants

    ...and 5 more risk factors

  • Higher blood pressure

    Uncontrolled high blood pressure

  • Suicidal behavior

    Taking medicines for seizures

  • Blood vessel issues

    High blood pressure

    ...and 1 more risk factors

See more detailed risks and warnings