Compare Amerge vs. Onzetra

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Amerge
(naratriptan)

Onzetra
(sumatriptan)

Treats migraine headaches. Amerge (naratriptan) isn't as good as other similar medications for migraines, but can be good if other drugs haven't worked for you.Treats migraine headaches. Onzetra (sumatriptan) is the only medicine that's available in a breath-powered nose powder to treat migraines. However, it can be expensive compared to other medicines.
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Coupons for Amerge
Best available price for 9 (9 tablets of 2.5mg) dose packs of amerge
Coupons for Onzetra
Best available price for 16 (16 nosepieces of 11mg) cartons of onzetra
Reviews & ratings
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Have you used Amerge (naratriptan)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Onzetra (sumatriptan)?
Worth itNot sureNot worth it
Side effects
AmergeOnzetra
  • Stomach problems 1%
  • Nervous system issues 1%
  • Unusual sensation 1%
  • Fatigue or uneasiness 1%
  • Tingling or prickling sensation 2%
  • Dizziness 1%
  • Drowsiness 2%
  • Pain & pressure in throat or neck 1%
More Amerge side effects »
  • Changes in taste 17%
  • Discomfort in the nose 10%
  • Runny nose 3%
  • Stuffy nose 2%
More Onzetra side effects »
How it works
AmergeOnzetra
Amerge (naratriptan) is a selective serotonin receptor agonist or triptan. Migraine headaches happen when blood vessels are too open and allow too much blood in the brain. Amerge (naratriptan) tightens the blood vessels which relieves the pain.Onzetra (sumatriptan) is a selective serotonin receptor agonist called a triptan. It's believed that migraine headaches happen when blood vessels are too open and allow too much blood in the brain. Onzetra (sumatriptan) tightens the blood vessels, which relieves the pain.
Type of medication
AmergeOnzetra
Prescription onlyPrescription only
Available as
AmergeOnzetra
  • Pill
  • Nasal powder
Used for
AmergeOnzetra
Risk factors for serious side effects
AmergeOnzetra
  • Heart disease
  • history of chest pain/angina
  • uncontrolled high blood pressure
  • History of a stroke
  • Using Amerge (naratriptan) for more than 10 days a month
Detailed Amerge (naratriptan) risks & warnings »
  • Heart disease
  • History of chest pain
  • Uncontrolled high blood pressure
  • History of a stroke
  • Using Onzetra (sumatriptan) for more than 10 days a month
Detailed Onzetra (sumatriptan) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Upsides and benefits
AmergeOnzetra
  • Amerge (naratriptan) is a good alternative to other triptans since it's less likely to cause side effects and if other triptans haven't worked for you.
  • Available as a generic, which makes it cheaper than other medicines and is more likely to be covered by insurances.
  • Amerge (naratriptan) comes in two different strengths.
  • Compared to pills, Onzetra (sumatriptan) is better absorbed in the body and good if it's hard to take pills.
  • Onzetra (sumatriptan) is a first choice medicine to treat migraines.
  • There is a copay program available that can make Onzetra (sumatriptan) cheaper.
Downsides and risks
AmergeOnzetra
  • Amerge (naratriptan) is only available as a pill that must be swallowed, so it might not be good if you have trouble swallowing when you have a migraine.
  • Unlike other migraine medications, you have to wait for 4 hours before you can take the second dose of Amerge (naratriptan).
  • Amerge (naratriptan) is not as good as other medications for treating nausea that can happen with migraines.
  • It can be very expensive. There are other forms of this same medicine that are much cheaper, including a nose spray.
  • You have to use two nosepieces to get the full dose of Onzetra (sumatriptan), which can be hard to remember.
  • Onzetra (sumatriptan) is only available in one strength.
Tips from our pharmacists for people taking the medication
AmergeOnzetra
  • Amerge (naratriptan) can only treat a migraine that's already happening. Amerge (naratriptan) doesn't prevent migraines.
  • Take Amerge (naratriptan) at the first sign of a migraine. You can take another dose if you don't feel better after 4 hours. Don't take more than two doses every 24 hours.
  • Amerge (naratriptan) can make you feel dizzy or tired when you first start taking it. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • If you finish the entire month's supply of Amerge (naratriptan) before it's time for your next refill, or if you have more than 4 migraines a month, talk to your doctor to see if you should try something else.
  • Amerge (naratriptan) can cause nausea or tightness in the chest or throat. Talk to your doctor if it bothers you.
  • Follow the instructions exactly as shown by the package insert and your doctor or pharmacist; otherwise, Onzetra (sumatriptan) won't work correctly and you won't get any medicine.
  • Onzetra (sumatriptan) can only treat a migraine that's already happening. You can't use it to stop migraines from starting.
  • You have to use 2 nosepieces of Onzetra (sumatriptan) to get the full dose of medicine.
  • Don't use more than 2 full doses (4 nosepieces) in a 24-hour period.
  • If you're using more than 8 doses of Onzetra (sumatriptan) a month, talk to your doctor to see if you should try another medicine.
  • You can only use each nosepiece of Onzetra (sumatriptan) once. Throw it away in the trash after you've checked that you used the medicine correctly.
Learn more
More about AmergeSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Amerge (naratriptan)?
Worth itNot sureNot worth it
More about OnzetraSide effectsAlternativesFDA package insert
Have you used Onzetra (sumatriptan)?
Worth itNot sureNot worth it