Compare amoxapine vs. Anafranil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Asendin
(amoxapine)

Anafranil
(clomipramine)

Stabilizes your mood. While Asendin (amoxapine) can treat depression, you have to take it several times a day and it can make you feel sleepy.Helps with your actions. Anafranil (Clomipramine) is helpful in treating OCD, but it can have a lot of side effects.
Reviews & ratings
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Have you used Asendin (amoxapine)?
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Have you used Anafranil (clomipramine)?
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Side effects
amoxapineAnafranil
  • Drowsiness or fatigue 14%
  • Dry mouth 14%
  • Constipation 12%
  • Vision changes 7%
More amoxapine side effects »
  • Dry mouth 67%
  • Tremor 52%
  • Dizziness 40%
  • Drowsiness 38%
  • Headache 11%
  • Constipation 36%
  • Ejaculation failure 40%
  • Fatigue 21%
More Anafranil side effects »
How it works
amoxapineAnafranil
Asendin (amoxapine) is a tricyclic antidepressant. It increases the activity of serotonin and norepinephrine in your brain which regulate your mood.Anafranil (Clomipramine) is a tricyclic antidepressant (TCA). It treats obsessive-compulsive disorder by affecting the levels of serotonin and norepinephrine in your brain.
Type of medication
amoxapineAnafranil
Prescription onlyPrescription only
Available as
amoxapineAnafranil
  • Pill
  • Pill
Used for
amoxapineAnafranil
Risk factors for serious side effects
amoxapineAnafranil
  • People under age 24
  • Glaucoma
  • Taking antidepressants
  • Taking opioids for pain relief or medicines for anxiety
  • Over age 65
Detailed Asendin (amoxapine) risks & warnings »
  • Age 24 years or younger
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Using other medications that affect serotonin
  • History of seizure
Detailed Anafranil (clomipramine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
amoxapineAnafranil
  • Take Asendin (amoxapine) with food to avoid stomach upset.
  • Take it with food and/or at bedtime to decrease the potential side effects.
Sleep
amoxapineAnafranil
  • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Can help you sleep.
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
Upsides and benefits
amoxapineAnafranil
  • Asendin (amoxapine) can be used to treat more severe forms of depression.
  • Compared to similar medicines, Asendin (amoxapine) improves the mood in depression more quickly.
  • Asendin (amoxapine) is available as generic.
  • Works well to decrease the symptoms of obsessive-compulsive disorder (OCD).
  • Helps some people see improvements in their mood.
  • Can help you sleep.
  • Lower risk of causing heart problems compared to other medicine in this class.
Downsides and risks
amoxapineAnafranil
  • Asendin (amoxapine) is not a first choice medicine for depression because of side effects.
  • In some people, Asendin (amoxapine) can stop working as early as 2-3 months after you start taking it.
  • Not recommended in older people, children under 16, or people who've had a history of seizures.
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
  • Can cause sexual performance problems in men.
  • Increases the risk of falls, especially when used in the elderly.
Tips from our pharmacists for people taking the medication
amoxapineAnafranil
  • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • You might not notice any changes in your mood for at least a few weeks.
  • Take Asendin (amoxapine) with food to avoid stomach upset.
  • You're more likely to be dehydrated and constipated. Drink plenty of fluids and be careful not to get overheated if you're out in the sun.
  • Don't stop taking Asendin (amoxapine) without talking to your doctor. Stopping Asendin (amoxapine) suddenly can be very dangerous.
  • Needs to be taken every day for 2 to 3 weeks to see the full effect of the medication.
  • It's important to keep taking Anafranil (Clomipramine) even when you feel your symptoms are getting better.
  • Take it with food and/or at bedtime to decrease the potential side effects.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • If you decide to stop taking Anafranil (Clomipramine), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
Learn more
More about amoxapineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Asendin (amoxapine)?
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More about AnafranilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Anafranil (clomipramine)?
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