Compare amoxapine vs. Anafranil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Asendin (amoxapine)

Prescription only

Anafranil (Clomipramine)

Prescription only
Stabilizes your mood.

While Asendin (amoxapine) can treat depression, you have to take it several times a day and it can make you feel sleepy.

Helps with your actions.

Anafranil (Clomipramine) is helpful in treating OCD, but it can have a lot of side effects.

Upsides
  • Asendin (amoxapine) can be used to treat more severe forms of depression.
  • Compared to similar medicines, Asendin (amoxapine) improves the mood in depression more quickly.
  • Asendin (amoxapine) is available as generic.
  • Works well to decrease the symptoms of obsessive-compulsive disorder (OCD).
  • Helps some people see improvements in their mood.
  • Can help you sleep.
  • Lower risk of causing heart problems compared to other medicine in this class.
Downsides
  • Asendin (amoxapine) is not a first choice medicine for depression because of side effects.
  • In some people, Asendin (amoxapine) can stop working as early as 2-3 months after you start taking it.
  • Not recommended in older people, children under 16, or people who've had a history of seizures.
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
  • Can cause sexual performance problems in men.
  • Increases the risk of falls, especially when used in the elderly.
Used for
Dosage forms
  • Pill
  • Pill
Price
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Reviews
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Side effects
4possible side effects
  • Drowsiness or fatigue
    14%
  • Dry mouth
    14%
  • Constipation
    12%
  • Vision changes
    7%
See more detailed side effects
109possible side effects
  • Dry mouth
    84%
  • Somnolence
    54%
  • Tremor
    54%
  • Dizziness
    54%
  • Headache
    52%
  • Constipation
    47%
  • Ejaculation failure
    42%
  • Fatigue
    39%
  • Nausea
    33%
  • Increased sweating
    28%
  • Insomnia
    25%
  • Dyspepsia
    22%
  • Anorexia
    22%
  • Libido change
    21%
  • Any side effect
    20%
  • Impotence
    20%
  • Nervousness
    18%
  • Weight increase
    18%
  • Abnormal vision
    18%
  • Pharyngitis
    14%
  • Micturition disorder
    14%
  • Myoclonus
    13%
  • Diarrhea
    13%
  • Myalgia
    13%
  • Abdominal pain
    13%
  • Rhinitis
    12%
  • Dysmenorrhea
    12%
  • Increased appetite
    11%
  • Digestive system complaints, mainly nausea and vomiting
    10%
  • Paresthesia
    9%
  • Memory impairment
    9%
  • Anxiety
    9%
  • Sleep disorder
    9%
  • Rash
    8%
  • Flushing
    8%
  • Taste perversion
    8%
  • Twitching
    7%
  • Vomiting
    7%
  • Chest pain
    7%
  • Allergy
    7%
  • Weight decrease
    7%
  • Bronchospasm
    7%
  • Urinary retention
    7%
  • Pruritus
    6%
  • Flatulence
    6%
  • Postural hypotension
    6%
  • Sinusitis
    6%
  • Coughing
    6%
  • Urinary tract infection
    6%
  • Tinnitus
    6%
  • Back pain
    6%
  • Nervous system complaints, mainly somnolence
    5%
  • Impaired concentration
    5%
  • Depression
    5%
  • Tooth disorder
    5%
  • Hot flushes
    5%
  • Micturition frequency
    5%
  • Hypertonia
    4%
  • Fever
    4%
  • Palpitation
    4%
  • Tachycardia
    4%
  • Lactation (nonpuerperal)
    4%
  • Menstrual disorder
    4%
  • Pain
    4%
  • Otitis media
    4%
  • Psychosomatic disorder
    3%
  • Yawning
    3%
  • Confusion
    3%
  • Speech disorder
    3%
  • Abnormal dreaming
    3%
  • Agitation
    3%
  • Migraine
    3%
  • Abnormal lacrimation
    3%
  • Arthralgia
    3%
  • Depersonalization
    2%
  • Irritability
    2%
  • Emotional lability
    2%
  • Dermatitis
    2%
  • Acne
    2%
  • Dry skin
    2%
  • Gastrointestinal disorder
    2%
  • Dysphagia
    2%
  • Local edema
    2%
  • Chills
    2%
  • Epistaxis
    2%
  • Dysuria
    2%
  • Cystitis
    2%
  • Vaginitis
    2%
  • Leukorrhea
    2%
  • Breast enlargement
    2%
  • Mydriasis
    2%
  • Thirst
    2%
  • Panic reaction
    2%
  • Aggressive reaction
    2%
  • Paresis
    2%
  • Abnormal skin odor
    2%
  • Eructation
    2%
  • Ulcerative stomatitis
    2%
  • Asthenia
    2%
  • Halitosis
    2%
  • Syncope
    2%
  • Dyspnea
    2%
  • Laryngitis
    2%
  • Anisocoria
    2%
  • Blepharospasm
    2%
  • Ocular allergy
    2%
  • Vestibular disorder
    2%
  • Muscle weakness
    2%
  • Anemia
    2%
See more detailed side effects
Risks and risk factors
  • Increased risk of suicide
    • People under age 24
  • Vision changes
    • Glaucoma
  • Difficulty controlling movements
  • Neuroleptic malignant syndrome
    • Taking antidepressants
  • Slowed breathing
    • Taking opioids for pain relief or medicines for anxiety
  • Anticholinergic effects/Dehydration
    • Over age 65
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
  • Serotonin syndrome
    • Using other medications that affect serotonin
  • Seizure
    • History of seizure
    • Taking other medicines that increase seizure risk
    • Alcoholism
  • Withdrawal
    • Stopping Anafranil (Clomipramine) suddenly
  • Low blood pressure
    • Age 65 years or older
  • Heart problems
    • History of heart disease
    • Older age
    • Electrolyte imbalance
See more detailed risks and warnings