Compare amoxapine vs. Doxepin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Asendin (amoxapine)

Prescription only

Zonalon (Doxepin)

Prescription only
Stabilizes your mood.

While Asendin (amoxapine) can treat depression, you have to take it several times a day and it can make you feel sleepy.

Helps you stop itching.

Zonalon (Doxepin) works well treating itchy skin, but could make you sleepy.

Upsides
  • Asendin (amoxapine) can be used to treat more severe forms of depression.
  • Compared to similar medicines, Asendin (amoxapine) improves the mood in depression more quickly.
  • Asendin (amoxapine) is available as generic.
  • In clinical trials, Zonalon (Doxepin) was found to be the most effective cream for treating itchy skin.
  • You can use Zonalon (Doxepin) for up to 8 days at a time.
Downsides
  • Asendin (amoxapine) is not a first choice medicine for depression because of side effects.
  • In some people, Asendin (amoxapine) can stop working as early as 2-3 months after you start taking it.
  • Not recommended in older people, children under 16, or people who've had a history of seizures.
  • You need a prescription for Zonalon (Doxepin).
  • It isn't available as a generic, so it could be kind of pricey.
  • Zonalon (Doxepin) can make you sleepy.
  • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
Used for
  • Skin intching (moderate)
Dosage forms
  • Pill
  • Cream, gel, or ointment
Price
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$19.44
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Lowest price near you
$9.99
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Reviews
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Side effects
4possible side effects
  • Drowsiness or fatigue
    14%
  • Dry mouth
    14%
  • Constipation
    12%
  • Vision changes
    7%
See more detailed side effects
The Zonalon (Doxepin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Increased risk of suicide

    People under age 24

  • Vision changes

    Glaucoma

  • Neuroleptic malignant syndrome

    Taking antidepressants

  • Slowed breathing

    Taking opioids for pain relief or medicines for anxiety

  • Anticholinergic effects/Dehydration

    Over age 65

See more detailed risks and warnings