Compare amoxapine vs. Doxepin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Asendin
(amoxapine)

Zonalon
(doxepin)

Stabilizes your mood. While Asendin (amoxapine) can treat depression, you have to take it several times a day and it can make you feel sleepy.Helps you stop itching. Zonalon (Doxepin) works well treating itchy skin, but could make you sleepy.
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Coupons for amoxapine
Best available price for 30 (50mg) tablets of amoxapine
Coupons for Doxepin
Best available price for 30 (10mg) capsules of doxepin
Reviews & ratings
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Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Asendin (amoxapine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Zonalon (doxepin)?
Worth itNot sureNot worth it
Side effects
amoxapineDoxepin
  • Drowsiness or fatigue 14%
  • Dry mouth 14%
  • Constipation 12%
  • Vision changes 7%
More amoxapine side effects »

We haven’t found good data for Doxepin side effects.

FDA side effect reports for Doxepin »
How it works
amoxapineDoxepin
Asendin (amoxapine) is a tricyclic antidepressant. It increases the activity of serotonin and norepinephrine in your brain which regulate your mood.Zonalon (Doxepin) is an cream that stops you from itching by blocking the chemical receptors that cause itching.
Type of medication
amoxapineDoxepin
Prescription onlyPrescription only
Available as
amoxapineDoxepin
  • Pill
  • Cream, gel, or ointment
Used for
amoxapineDoxepin
  • Skin Intching Moderate
Risk factors for serious side effects
amoxapineDoxepin
  • People under age 24
  • Glaucoma
  • Taking antidepressants
  • Taking opioids for pain relief or medicines for anxiety
  • Over age 65
Detailed Asendin (amoxapine) risks & warnings »
    Detailed Zonalon (doxepin) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Price
    amoxapineDoxepin
    No price related info.
    • It isn't available as a generic, so it could be kind of pricey.
    Interactions
    amoxapineDoxepin
    No interactions related info.
    • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
    Food
    amoxapineDoxepin
    • Take Asendin (amoxapine) with food to avoid stomach upset.
    No food related info.
    Sleep
    amoxapineDoxepin
    • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
    • Zonalon (Doxepin) can make you sleepy.
    Upsides and benefits
    amoxapineDoxepin
    • Asendin (amoxapine) can be used to treat more severe forms of depression.
    • Compared to similar medicines, Asendin (amoxapine) improves the mood in depression more quickly.
    • Asendin (amoxapine) is available as generic.
    • In clinical trials, Zonalon (Doxepin) was found to be the most effective cream for treating itchy skin.
    • You can use Zonalon (Doxepin) for up to 8 days at a time.
    Downsides and risks
    amoxapineDoxepin
    • Asendin (amoxapine) is not a first choice medicine for depression because of side effects.
    • In some people, Asendin (amoxapine) can stop working as early as 2-3 months after you start taking it.
    • Not recommended in older people, children under 16, or people who've had a history of seizures.
    • You need a prescription for Zonalon (Doxepin).
    • It isn't available as a generic, so it could be kind of pricey.
    • Zonalon (Doxepin) can make you sleepy.
    • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
    Tips from our pharmacists for people taking the medication
    amoxapineDoxepin
    • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
    • You might not notice any changes in your mood for at least a few weeks.
    • Take Asendin (amoxapine) with food to avoid stomach upset.
    • You're more likely to be dehydrated and constipated. Drink plenty of fluids and be careful not to get overheated if you're out in the sun.
    • Don't stop taking Asendin (amoxapine) without talking to your doctor. Stopping Asendin (amoxapine) suddenly can be very dangerous.
    • Be sure the affected area is clean and dry before applying Zonalon (Doxepin).
    • Wash your hands before and after using it.
    • Apply a thin layer of Zonalon (Doxepin) onto the affected area and rub it in gently.
    • Don’t put a bandage, dressing, or make-up over Zonalon (Doxepin) once it's on your skin.
    • It shouldn't affect you too much, but avoid activities that need you to be fully alert (like driving) until you know how it works.
    Learn more
    More about amoxapineSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Asendin (amoxapine)?
    Worth itNot sureNot worth it
    More about DoxepinSide effectsFDA package insert
    Have you used Zonalon (doxepin)?
    Worth itNot sureNot worth it