Compare amoxapine vs. chlordiazepoxide / amitriptyline

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Asendin
(amoxapine)

Limbitrol
(chlordiazepoxide / amitriptyline)

Stabilizes your mood. While Asendin (amoxapine) can treat depression, you have to take it several times a day and it can make you feel sleepy.Treats anxiety and depression. While Limbitrol (chlordiazepoxide / amitriptyline) as a combination can be used to treat both anxiety and depression, other medicines are considered first choice because chlordiazepoxide can be potentially addicting.
Reviews & ratings
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Have you used Asendin (amoxapine)?
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Have you used Limbitrol (chlordiazepoxide / amitriptyline)?
Worth itNot sureNot worth it
Side effects
amoxapinechlordiazepoxide / amitriptyline
  • Drowsiness or fatigue 14%
  • Dry mouth 14%
  • Constipation 12%
  • Vision changes 7%
More amoxapine side effects »

The chlordiazepoxide / amitriptyline FDA package insert doesn’t have numbers about how common side effects are.

More about chlordiazepoxide / amitriptyline side effects »
How it works
amoxapinechlordiazepoxide / amitriptyline
Asendin (amoxapine) is a tricyclic antidepressant. It increases the activity of serotonin and norepinephrine in your brain which regulate your mood.Limbitrol (chlordiazepoxide / amitriptyline) is a combination of 2 medicines. Chlordiazepoxide is a benzodiazepine, and it calms activity in a part of the brain responsible for emotional responses. Amitriptyline is a tricyclic antidepressant, and it raises the amount of norepinephrine and serotonin in the brain, which can improve mood.
Type of medication
amoxapinechlordiazepoxide / amitriptyline
Prescription onlyPrescription only
Available as
amoxapinechlordiazepoxide / amitriptyline
  • Pill
  • Pill
Used for
amoxapinechlordiazepoxide / amitriptyline
  • Anxiety And Depression
Risk factors for serious side effects
amoxapinechlordiazepoxide / amitriptyline
  • People under age 24
  • Glaucoma
  • Taking antidepressants
  • Taking opioids for pain relief or medicines for anxiety
  • Over age 65
Detailed Asendin (amoxapine) risks & warnings »
  • People under age 24
  • Glaucoma
  • Heart disease
  • Alcohol
  • Taking narcotics, tranquilizers, or antihistamines
Detailed Limbitrol (chlordiazepoxide / amitriptyline) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
amoxapinechlordiazepoxide / amitriptyline
No alcohol related info.
  • Don't drink alcohol or take narcotics, tranquilizers, or antihistamines if you're taking Limbitrol (chlordiazepoxide / amitriptyline). This can slow down your breathing. Talk to your doctor if this is a problem.
  • Don't drink alcohol or take any narcotics while taking Limbitrol (chlordiazepoxide / amitriptyline) since it can slow your breathing.
Food
amoxapinechlordiazepoxide / amitriptyline
  • Take Asendin (amoxapine) with food to avoid stomach upset.
No food related info.
Sleep
amoxapinechlordiazepoxide / amitriptyline
  • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Limbitrol (chlordiazepoxide / amitriptyline) can make you sleepy and unable to focus, so don't drive or do anything requiring concentration for a few hours after taking it until you know how it affects you. This can be worse if you drink alcohol or take narcotics.
Upsides and benefits
amoxapinechlordiazepoxide / amitriptyline
  • Asendin (amoxapine) can be used to treat more severe forms of depression.
  • Compared to similar medicines, Asendin (amoxapine) improves the mood in depression more quickly.
  • Asendin (amoxapine) is available as generic.
  • Limbitrol (chlordiazepoxide / amitriptyline) is available as a generic.
  • Limbitrol (chlordiazepoxide / amitriptyline) works faster than amitriptyline alone.
Downsides and risks
amoxapinechlordiazepoxide / amitriptyline
  • Asendin (amoxapine) is not a first choice medicine for depression because of side effects.
  • In some people, Asendin (amoxapine) can stop working as early as 2-3 months after you start taking it.
  • Not recommended in older people, children under 16, or people who've had a history of seizures.
  • Limbitrol (chlordiazepoxide / amitriptyline) is only available in certain strengths, so it can be difficult to customize a dose that treats both anxiety and depression.
  • Limbitrol (chlordiazepoxide / amitriptyline) contains chlordiazepoxide, which can be potentially addicting.
  • You might not notice any changes in your mood until you've been taking Limbitrol (chlordiazepoxide / amitriptyline) for several weeks.
  • Amitriptyline alone is considered a better treatment for anxiety and depression than Limbitrol (chlordiazepoxide / amitriptyline).
  • Other medicines are considered first choice for treating anxiety and depression over Limbitrol (chlordiazepoxide / amitriptyline).
Tips from our pharmacists for people taking the medication
amoxapinechlordiazepoxide / amitriptyline
  • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • You might not notice any changes in your mood for at least a few weeks.
  • Take Asendin (amoxapine) with food to avoid stomach upset.
  • You're more likely to be dehydrated and constipated. Drink plenty of fluids and be careful not to get overheated if you're out in the sun.
  • Don't stop taking Asendin (amoxapine) without talking to your doctor. Stopping Asendin (amoxapine) suddenly can be very dangerous.
  • Don't drink alcohol or take any narcotics while taking Limbitrol (chlordiazepoxide / amitriptyline) since it can slow your breathing.
  • If you've taken Limbitrol (chlordiazepoxide / amitriptyline) for an extended amount of time, don't stop taking it suddenly without talking to your doctor first. It can be very dangerous.
  • Don't drive or do anything requiring concentration while taking Limbitrol (chlordiazepoxide / amitriptyline) since it can make you sleepy. This can be worse if you drink alcohol or take narcotics.
  • You might not notice changes in your mood until you've taken Limbitrol (chlordiazepoxide / amitriptyline) for at least a few weeks.
  • If you're being switched to Limbitrol (chlordiazepoxide / amitriptyline) from a group of medicines called monoamine oxidase inhibitors (MAOI), you should wait at least 14 days before you start.
Learn more
More about amoxapineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Asendin (amoxapine)?
Worth itNot sureNot worth it
More about chlordiazepoxide / amitriptylineSide effectsAlternativesFDA package insert
Have you used Limbitrol (chlordiazepoxide / amitriptyline)?
Worth itNot sureNot worth it