Compare amoxapine vs. chlordiazepoxide / amitriptyline

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Stabilizes your mood.

While Asendin (amoxapine) can treat depression, you have to take it several times a day and it can make you feel sleepy.

Treats anxiety and depression.

While Limbitrol (chlordiazepoxide / amitriptyline) as a combination can be used to treat both anxiety and depression, other medicines are considered first choice because chlordiazepoxide can be potentially addicting.

Upsides
  • Asendin (amoxapine) can be used to treat more severe forms of depression.
  • Compared to similar medicines, Asendin (amoxapine) improves the mood in depression more quickly.
  • Asendin (amoxapine) is available as generic.
  • Limbitrol (chlordiazepoxide / amitriptyline) is available as a generic.
  • Limbitrol (chlordiazepoxide / amitriptyline) works faster than amitriptyline alone.
Downsides
  • Asendin (amoxapine) is not a first choice medicine for depression because of side effects.
  • In some people, Asendin (amoxapine) can stop working as early as 2-3 months after you start taking it.
  • Not recommended in older people, children under 16, or people who've had a history of seizures.
  • Limbitrol (chlordiazepoxide / amitriptyline) is only available in certain strengths, so it can be difficult to customize a dose that treats both anxiety and depression.
  • Limbitrol (chlordiazepoxide / amitriptyline) contains chlordiazepoxide, which can be potentially addicting.
  • You might not notice any changes in your mood until you've been taking Limbitrol (chlordiazepoxide / amitriptyline) for several weeks.
  • Amitriptyline alone is considered a better treatment for anxiety and depression than Limbitrol (chlordiazepoxide / amitriptyline).
  • Other medicines are considered first choice for treating anxiety and depression over Limbitrol (chlordiazepoxide / amitriptyline).
Used for
  • Anxiety and depression
Dosage forms
  • Pill
  • Pill
Price
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Reviews
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Side effects
4possible side effects
  • Drowsiness or fatigue
    14%
  • Dry mouth
    14%
  • Constipation
    12%
  • Vision changes
    7%
See more detailed side effects
The Limbitrol (chlordiazepoxide / amitriptyline) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Increased risk of suicide
    • People under age 24
  • Vision changes
    • Glaucoma
  • Difficulty controlling movements
  • Neuroleptic malignant syndrome
    • Taking antidepressants
  • Slowed breathing
    • Taking opioids for pain relief or medicines for anxiety
  • Anticholinergic effects/Dehydration
    • Over age 65
See more detailed risks and warnings
  • Higher risk of suicide
    • People under age 24
  • Breathing problems
  • Possible bipolar disorder
  • Vision changes
    • Glaucoma
  • Changes in heartbeat, heart attack, or stroke
    • Heart disease
  • Breathing problems
    • Alcohol
    • Taking narcotics, tranquilizers, or antihistamines
  • Drowsiness and sleepiness
    • Drinking alcohol or taking narcotics
See more detailed risks and warnings
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Disclaimer: We don't provide medical advice. If you think you might have a medical emergency, call your doctor or 911 immediately.