Compare amoxapine vs. maprotiline

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Asendin
(amoxapine)

Ludiomil
(maprotiline)

Stabilizes your mood. While Asendin (amoxapine) can treat depression, you have to take it several times a day and it can make you feel sleepy.Stabilizes your mood. While Ludiomil (maprotiline) is part of the first choice of medicines to treat depression, it can cause drowsiness and dehydration.
Reviews & ratings
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Have you used Asendin (amoxapine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Ludiomil (maprotiline)?
Worth itNot sureNot worth it
Side effects
amoxapinemaprotiline
  • Drowsiness or fatigue 14%
  • Dry mouth 14%
  • Constipation 12%
  • Vision changes 7%
More amoxapine side effects »
  • Dry mouth 22%
  • Drowsiness 16%
  • Dizziness 8%
  • Constipation 6%
  • Nervousness 6%
  • Weakness & fatigue 4%
  • Headache 4%
  • Vision changes 4%
  • Anxiety 3%
  • Difficulty controlling movements 3%
More maprotiline side effects »
How it works
amoxapinemaprotiline
Asendin (amoxapine) is a tricyclic antidepressant. It increases the activity of serotonin and norepinephrine in your brain which regulate your mood.Ludiomil (maprotiline) is a tricyclic antidepressant. It raises the amount of norepinephrine in the brain, which is believed to be one of the chemicals that regulates mood.
Type of medication
amoxapinemaprotiline
Prescription onlyPrescription only
Available as
amoxapinemaprotiline
  • Pill
  • Pill
Used for
amoxapinemaprotiline
Risk factors for serious side effects
amoxapinemaprotiline
  • People under age 24
  • Glaucoma
  • Taking antidepressants
  • Taking opioids for pain relief or medicines for anxiety
  • Over age 65
Detailed Asendin (amoxapine) risks & warnings »
  • People under age 24
  • History of heart attack or heart disease
Detailed Ludiomil (maprotiline) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Food
amoxapinemaprotiline
  • Take Asendin (amoxapine) with food to avoid stomach upset.
No food related info.
Sleep
amoxapinemaprotiline
  • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
No sleep related info.
Weight
amoxapinemaprotiline
No weight related info.
  • Ludiomil (maprotiline) can cause weight gain, fainting, and make you feel dehydrated.
Upsides and benefits
amoxapinemaprotiline
  • Asendin (amoxapine) can be used to treat more severe forms of depression.
  • Compared to similar medicines, Asendin (amoxapine) improves the mood in depression more quickly.
  • Asendin (amoxapine) is available as generic.
  • Ludiomil (maprotiline) is available in generic.
  • Ludiomil (maprotiline) doesn't cause sleep problems, unlike other medicines used to treat depression.
Downsides and risks
amoxapinemaprotiline
  • Asendin (amoxapine) is not a first choice medicine for depression because of side effects.
  • In some people, Asendin (amoxapine) can stop working as early as 2-3 months after you start taking it.
  • Not recommended in older people, children under 16, or people who've had a history of seizures.
  • Ludiomil (maprotiline) can make you very drowsy compared to other similar medicines.
  • Ludiomil (maprotiline) can cause weight gain, fainting, and make you feel dehydrated.
  • Stopping Ludiomil (maprotiline) suddenly without telling your doctor can be dangerous.
  • You might not notice changes in your mood until you've taken Ludiomil (maprotiline) for several weeks.
Tips from our pharmacists for people taking the medication
amoxapinemaprotiline
  • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • You might not notice any changes in your mood for at least a few weeks.
  • Take Asendin (amoxapine) with food to avoid stomach upset.
  • You're more likely to be dehydrated and constipated. Drink plenty of fluids and be careful not to get overheated if you're out in the sun.
  • Don't stop taking Asendin (amoxapine) without talking to your doctor. Stopping Asendin (amoxapine) suddenly can be very dangerous.
  • If you've taken Ludiomil (maprotiline) for a long time, don't stop taking it suddenly without talking to your doctor first. It can be very dangerous.
  • Don't drive or do anything requiring concentration while taking Ludiomil (maprotiline) until you know how it affects you since it can make you sleepy. This can be worse if you drink alcohol or take narcotics.
  • You might not notice changes in your mood until you've taken Ludiomil (maprotiline) for at least a few weeks.
  • If you forget your regular dose of Ludiomil (maprotiline), take it as soon as you remember. However, don't take 2 doses at the same time if it's already time for your next dose.
  • You might feel dizzy the first few days you take Ludiomil (maprotiline), which can make you fall. Be very careful getting up if you've been sitting or lying down for a while. Brace yourself and sit back down if you're feeling dizzy.
  • Ludiomil (maprotiline) can also cause constipation. Eat plenty of fruits and vegetables, or use stool softeners or laxatives.
Learn more
More about amoxapineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Asendin (amoxapine)?
Worth itNot sureNot worth it
More about maprotilineSide effectsAlternativesFDA package insert
Have you used Ludiomil (maprotiline)?
Worth itNot sureNot worth it