Compare amoxapine vs. desipramine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Asendin
(amoxapine)

Norpramin
(desipramine)

Stabilizes your mood. While Asendin (amoxapine) can treat depression, you have to take it several times a day and it can make you feel sleepy.Stabilizes your mood. Norpramin (desipramine) is not a first choice for treating depression because of its effects on the heart, but it can be good if other medicines haven't worked.
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Prices and coupon for 30 (50mg) tablets of amoxapine
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Prices and coupon for 30 (10mg) tablets of desipramine
Reviews & ratings
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Have you used Asendin (amoxapine)?
Worth itNot sureNot worth it

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Have you used Norpramin (desipramine)?
Worth itNot sureNot worth it
Side effects
amoxapinedesipramine
  • Drowsiness or fatigue 14%
  • Dry mouth 14%
  • Constipation 12%
  • Vision changes 7%
More amoxapine side effects »

The desipramine FDA package insert doesn’t have numbers about how common side effects are.

More about desipramine side effects »
How it works
amoxapinedesipramine
Asendin (amoxapine) is a tricyclic antidepressant. It increases the activity of serotonin and norepinephrine in your brain which regulate your mood.Norpramin (desipramine) is a tricyclic antidepressant. It increases the amount of norepinephrine and serotonin in the brain, two chemicals that regulate mood.
Type of medication
amoxapinedesipramine
Prescription only
Prescription only
Available as
amoxapinedesipramine
  • Pill
  • Pill
Used for
amoxapinedesipramine
Risk factors for serious side effects
amoxapinedesipramine
  • People under age 24
  • Glaucoma
    • Taking antidepressants
    • Taking opioids for pain relief or medicines for anxiety
    • Over age 65
    Detailed Asendin (amoxapine) risks & warnings »
    • People under age 24
      • Tricyclic antidepressants
      • Fentanyl
      • Tramadol
      • Buspirone
      • ADHD medicines
      • Triptans
      • History of heart disease
      • History of seizures
      • History of brain damage or alcohol withdrawal
      Detailed Norpramin (desipramine) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      Food
      amoxapinedesipramine
      • Take Asendin (amoxapine) with food to avoid stomach upset.
      No food related info.
      Sleep
      amoxapinedesipramine
      • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
      No sleep related info.
      Upsides and benefits
      amoxapinedesipramine
      • Asendin (amoxapine) can be used to treat more severe forms of depression.
      • Compared to similar medicines, Asendin (amoxapine) improves the mood in depression more quickly.
      • Asendin (amoxapine) is available as generic.
      • Norpramin (desipramine) is available in generic and in many different strengths, so the dose can be more customized.
      • Norpramin (desipramine) has fewer side effects than similar tricyclic antidepressants.
      Downsides and risks
      amoxapinedesipramine
      • Asendin (amoxapine) is not a first choice medicine for depression because of side effects.
      • In some people, Asendin (amoxapine) can stop working as early as 2-3 months after you start taking it.
      • Not recommended in older people, children under 16, or people who've had a history of seizures.
      • Norpramin (desipramine) isn't recommended if you or your family has heart disease, seizures, or glaucoma.
      • Norpramin (desipramine) isn't a first choice for depression because it has more side effects than other antidepressants.
      • In some people, Norpramin (desipramine) can make you sleepy. In other people, Norpramin (desipramine) can keep you awake.
      • If you have diabetes, Norpramin (desipramine) can make your blood sugar go up.
      • Not recommended in children under 12 years of age.
      Tips from our pharmacists for people taking the medication
      amoxapinedesipramine
      • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
      • You might not notice any changes in your mood for at least a few weeks.
      • Take Asendin (amoxapine) with food to avoid stomach upset.
      • You're more likely to be dehydrated and constipated. Drink plenty of fluids and be careful not to get overheated if you're out in the sun.
      • Don't stop taking Asendin (amoxapine) without talking to your doctor. Stopping Asendin (amoxapine) suddenly can be very dangerous.
      • Don't drive or do anything requiring concentration until you know how Norpramin (desipramine) affects you since it can make you feel sleepy.
      • Talk to your doctor right away if your mood suddenly darkens and you want to hurt yourself while taking Norpramin (desipramine).
      • If you're being switched to Norpramin (desipramine) from monoamine oxidase inhibitors, you'll need to wait 2 weeks before you can start it.
      • Don't stop taking Norpramin (desipramine) suddenly without talking to your doctor first.
      Learn more
      More about amoxapineSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Asendin (amoxapine)?
      Worth itNot sureNot worth it
      More about desipramineSide effectsAlternativesFDA package insert
      Have you used Norpramin (desipramine)?
      Worth itNot sureNot worth it