Compare amoxapine vs. Pamelor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Asendin
(amoxapine)

Pamelor
(nortriptyline)

Stabilizes your mood. While Asendin (amoxapine) can treat depression, you have to take it several times a day and it can make you feel sleepy.Improves your mood. Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.
Reviews & ratings
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Have you used Asendin (amoxapine)?
Worth itNot sureNot worth it
Reviews for Pamelor
79%
-79% worse vs. amoxapine
79%
-79% worse vs. amoxapine
21%
-79% worse vs. amoxapine
Have you used Pamelor (nortriptyline)?
Worth itNot sureNot worth it
Side effects
amoxapinePamelor
  • Drowsiness or fatigue 14%
  • Dry mouth 14%
  • Constipation 12%
  • Vision changes 7%
More amoxapine side effects »

We haven’t found good data for Pamelor side effects.

FDA side effect reports for Pamelor »
How it works
amoxapinePamelor
Asendin (amoxapine) is a tricyclic antidepressant. It increases the activity of serotonin and norepinephrine in your brain which regulate your mood.Pamelor (Nortriptyline) is a tricyclic antidepressant (TCA). It helps improve your mood by altering the levels of serotonin, norepinephrine, and other similar chemicals in your brain.
Type of medication
amoxapinePamelor
Prescription onlyPrescription only
Available as
amoxapinePamelor
  • Pill
  • Pill
  • Liquid
Used for
amoxapinePamelor
Risk factors for serious side effects
amoxapinePamelor
  • People under age 24
  • Glaucoma
  • Taking antidepressants
  • Taking opioids for pain relief or medicines for anxiety
  • Over age 65
Detailed Asendin (amoxapine) risks & warnings »
  • Age 24 years or younger
  • Age 65 years or older
  • Stopping Pamelor (Nortriptyline) suddenly
  • Using other medications that affect serotonin
  • History of heart disease
Detailed Pamelor (nortriptyline) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Food
amoxapinePamelor
  • Take Asendin (amoxapine) with food to avoid stomach upset.
  • Take it with food and/or at bedtime to decrease the potential side effects.
Sleep
amoxapinePamelor
  • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
No sleep related info.
Upsides and benefits
amoxapinePamelor
  • Asendin (amoxapine) can be used to treat more severe forms of depression.
  • Compared to similar medicines, Asendin (amoxapine) improves the mood in depression more quickly.
  • Asendin (amoxapine) is available as generic.
  • Helpful with treating certain types of pain, like migraines or nerve-related pain.
  • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
Downsides and risks
amoxapinePamelor
  • Asendin (amoxapine) is not a first choice medicine for depression because of side effects.
  • In some people, Asendin (amoxapine) can stop working as early as 2-3 months after you start taking it.
  • Not recommended in older people, children under 16, or people who've had a history of seizures.
  • Side effects are usually manageable, but can be annoying.
  • Increases the risk of falls, especially when used in the elderly.
  • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
Tips from our pharmacists for people taking the medication
amoxapinePamelor
  • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • You might not notice any changes in your mood for at least a few weeks.
  • Take Asendin (amoxapine) with food to avoid stomach upset.
  • You're more likely to be dehydrated and constipated. Drink plenty of fluids and be careful not to get overheated if you're out in the sun.
  • Don't stop taking Asendin (amoxapine) without talking to your doctor. Stopping Asendin (amoxapine) suddenly can be very dangerous.
  • Needs to be taken every day for 1 to 2 weeks to start feeling better, and for 6 to 8 weeks to see the full effect of the medication.
  • It's important to keep taking Pamelor (Nortriptyline) even when you feel your symptoms are getting better.
  • Take it with food and/or at bedtime to decrease the potential side effects.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • If you decide to stop taking Pamelor (Nortriptyline), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
Learn more
More about amoxapineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Asendin (amoxapine)?
Worth itNot sureNot worth it
More about PamelorSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Pamelor (nortriptyline)?
Worth itNot sureNot worth it