Compare amoxapine vs. Silenor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Asendin
(amoxapine)

Silenor
(doxepin)

Stabilizes your mood. While Asendin (amoxapine) can treat depression, you have to take it several times a day and it can make you feel sleepy.Helps you relax, and sleep. Doxepin is a non-addictive way to help people stay asleep, but it comes with a list of side effects.
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Coupons for amoxapine
Best available price for 30 (50mg) tablets of amoxapine
Coupons for Silenor
Best available price for 30 (10mg) capsules of doxepin
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Asendin (amoxapine)
Not enough review data. Review it!
of people (All ages) say Asendin (amoxapine) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Asendin (amoxapine)?
Worth itNot sureNot worth it
Reviews for Silenor (doxepin)
Not enough review data. Review it!
+100% better vs. Asendin (amoxapine)
Not enough review data. Review it!
+50% better vs. Asendin (amoxapine)
Not enough review data. Review it!
+100% better vs. Asendin (amoxapine)
Have you used Silenor (doxepin)?
Worth itNot sureNot worth it
Side effects
amoxapineSilenor
  • Drowsiness or fatigue 14%
  • Dry mouth 14%
  • Constipation 12%
  • Vision changes 7%
More amoxapine side effects »

We haven’t found good data for Silenor side effects.

FDA side effect reports for Silenor »
How it works
amoxapineSilenor
Asendin (amoxapine) is a tricyclic antidepressant. It increases the activity of serotonin and norepinephrine in your brain which regulate your mood.Doxepin is a tricyclic antidepressant. It keeps norepinephrine and serotonin in your brain longer, helping you relax, and sleep. It also blocks the chemical that causes itch, and wakefulness.
Type of medication
amoxapineSilenor
Prescription only
Available as
amoxapineSilenor
  • Pill
  • Pill
  • Liquid
Used for
amoxapineSilenor
  • Alcoholism Anxiety Depression Anxiety Depression Anxiety Depression Psychoneurotic Personality Disorder Insomnia Pruritus Moderate
Risk factors for serious side effects
amoxapineSilenor
  • People under age 24
  • Glaucoma
  • Taking antidepressants
  • Taking opioids for pain relief or medicines for anxiety
  • Over age 65
Detailed Asendin (amoxapine) risks & warnings »
    Coming soon.
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Interactions
    amoxapineSilenor
    No interactions related info.
    • Doxepin can interact with many different medications, vitamins, and alternative treatments.
    Alcohol
    amoxapineSilenor
    No alcohol related info.
    • Stay away from alcohol while taking Doxepin, because it can slow your brain, and stop your breathing.
    Food
    amoxapineSilenor
    • Take Asendin (amoxapine) with food to avoid stomach upset.
    No food related info.
    Sleep
    amoxapineSilenor
    • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
    No sleep related info.
    Weight
    amoxapineSilenor
    No weight related info.
    • Doxepin can increase your appetite, leading to weight gain.
    Upsides and benefits
    amoxapineSilenor
    • Asendin (amoxapine) can be used to treat more severe forms of depression.
    • Compared to similar medicines, Asendin (amoxapine) improves the mood in depression more quickly.
    • Asendin (amoxapine) is available as generic.
    • In a clinical trial Doxepin was able to significantly improve sleep quality.
    • Doxepin helps improve your appetite, energy level, and sense of well-being, which increases your interests.
    • Once your body gets used to Doxepin, most of the side effects go away.
    • Doxepin comes in a generic form, so it is pretty cheap.
    • Doxepin is not addictive.
    Downsides and risks
    amoxapineSilenor
    • Asendin (amoxapine) is not a first choice medicine for depression because of side effects.
    • In some people, Asendin (amoxapine) can stop working as early as 2-3 months after you start taking it.
    • Not recommended in older people, children under 16, or people who've had a history of seizures.
    • Some people taking Doxepin walk, drive, eat, and have sex while sleeping. Be sure to tell your doctor if this happens to you.
    • Doxepin can increase your appetite, leading to weight gain.
    • Taking Doxepin can make emptying your bladder difficult.
    • Some people have suicidal thoughts when taking Doxepin.
    • Doxepin can interact with many different medications, vitamins, and alternative treatments.
    Tips from our pharmacists for people taking the medication
    amoxapineSilenor
    • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
    • You might not notice any changes in your mood for at least a few weeks.
    • Take Asendin (amoxapine) with food to avoid stomach upset.
    • You're more likely to be dehydrated and constipated. Drink plenty of fluids and be careful not to get overheated if you're out in the sun.
    • Don't stop taking Asendin (amoxapine) without talking to your doctor. Stopping Asendin (amoxapine) suddenly can be very dangerous.
    • Take Doxepin 30 minutes before bedtime so it starts working when you get in bed.
    • Avoid activities that need you to be fully alert like driving, until you know how Doxepin affects you.
    • Follow up with your doctor so he or she can make sure Doxepin is the right medication for your depression.
    • Stay away from alcohol while taking Doxepin, because it can slow your brain, and stop your breathing.
    • Some people get dry mouth, or constipation when taking Doxepin. Sugar free gum or candy can help the dry mouth, and drinking more fluid can help with constipation.
    • Avoid direct sunlight while taking this medication. When you can’t avoid it, be sure to use sunscreen. It’s also important to put on a long-sleeved shirt, pants, hat, and sunglasses.
    Learn more
    More about amoxapineSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Asendin (amoxapine)?
    Worth itNot sureNot worth it
    More about SilenorSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Silenor (doxepin)?
    Worth itNot sureNot worth it