Compare amoxapine vs. Surmontil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Asendin
(amoxapine)

Surmontil
(trimipramine)

Stabilizes your mood. While Asendin (amoxapine) can treat depression, you have to take it several times a day and it can make you feel sleepy.Improves your mood. Surmontil (trimipramine) is good at treating depression, but it can cause more side effects, like sleepiness and weight gain, compared to other medicines.
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Coupons for amoxapine
Best available price for 30 (50mg) tablets of amoxapine
Coupons for Surmontil
Best available price for 30 (100mg) capsules of surmontil
Reviews & ratings
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Have you used Asendin (amoxapine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Surmontil (trimipramine)?
Worth itNot sureNot worth it
Side effects
amoxapineSurmontil
  • Drowsiness or fatigue 14%
  • Dry mouth 14%
  • Constipation 12%
  • Vision changes 7%
More amoxapine side effects »

The Surmontil FDA package insert doesn’t have numbers about how common side effects are.

More about Surmontil side effects »
How it works
amoxapineSurmontil
Asendin (amoxapine) is a tricyclic antidepressant. It increases the activity of serotonin and norepinephrine in your brain which regulate your mood.Surmontil (trimipramine) is a tricyclic antidepressant. It raises the amount of serotonin and norepinephrine in the brain, 2 chemicals that are known to regulate mood.
Type of medication
amoxapineSurmontil
Prescription onlyPrescription only
Available as
amoxapineSurmontil
  • Pill
  • Pill
Used for
amoxapineSurmontil
Risk factors for serious side effects
amoxapineSurmontil
  • People under age 24
  • Glaucoma
  • Taking antidepressants
  • Taking opioids for pain relief or medicines for anxiety
  • Over age 65
Detailed Asendin (amoxapine) risks & warnings »
  • People under age 24
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
  • Buspirone
Detailed Surmontil (trimipramine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
amoxapineSurmontil
  • Take Asendin (amoxapine) with food to avoid stomach upset.
  • Can be taken with or without food.
Sleep
amoxapineSurmontil
  • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
No sleep related info.
Upsides and benefits
amoxapineSurmontil
  • Asendin (amoxapine) can be used to treat more severe forms of depression.
  • Compared to similar medicines, Asendin (amoxapine) improves the mood in depression more quickly.
  • Asendin (amoxapine) is available as generic.
  • Surmontil (trimipramine) is part of the first choice medicines to treat depression.
  • Available in generic and in three different strengths.
  • Can be taken once a day, usually before you go to bed.
  • Can be taken with or without food.
Downsides and risks
amoxapineSurmontil
  • Asendin (amoxapine) is not a first choice medicine for depression because of side effects.
  • In some people, Asendin (amoxapine) can stop working as early as 2-3 months after you start taking it.
  • Not recommended in older people, children under 16, or people who've had a history of seizures.
  • You might not notice changes in your mood until you've taken Surmontil (trimipramine) for several weeks.
  • Stopping Surmontil (trimipramine) suddenly without telling your doctor can be dangerous.
  • Surmontil (trimipramine) can cause more side effects than other medicines used to treat depression.
Tips from our pharmacists for people taking the medication
amoxapineSurmontil
  • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • You might not notice any changes in your mood for at least a few weeks.
  • Take Asendin (amoxapine) with food to avoid stomach upset.
  • You're more likely to be dehydrated and constipated. Drink plenty of fluids and be careful not to get overheated if you're out in the sun.
  • Don't stop taking Asendin (amoxapine) without talking to your doctor. Stopping Asendin (amoxapine) suddenly can be very dangerous.
  • Take Surmontil (trimipramine) at night since it can make you sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • If you forget a dose, take it as soon as you remember, unless it's time for your next dose. Don't take extra medicine to make up for the missed dose.
  • Don't stop taking Surmontil (trimipramine) without talking to your doctor first.
  • Be very careful getting up if you've been sitting or lying down for a while since you can feel dizzy.
Learn more
More about amoxapineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Asendin (amoxapine)?
Worth itNot sureNot worth it
More about SurmontilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Surmontil (trimipramine)?
Worth itNot sureNot worth it