Compare amoxapine vs. Surmontil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Asendin (amoxapine)

Prescription only

Surmontil (trimipramine)

Prescription only
Stabilizes your mood.

While Asendin (amoxapine) can treat depression, you have to take it several times a day and it can make you feel sleepy.

Improves your mood.

Surmontil (trimipramine) is good at treating depression, but it can cause more side effects, like sleepiness and weight gain, compared to other medicines.

Upsides
  • Asendin (amoxapine) can be used to treat more severe forms of depression.
  • Compared to similar medicines, Asendin (amoxapine) improves the mood in depression more quickly.
  • Asendin (amoxapine) is available as generic.
  • Surmontil (trimipramine) is part of the first choice medicines to treat depression.
  • Available in generic and in three different strengths.
  • Can be taken once a day, usually before you go to bed.
  • Can be taken with or without food.
Downsides
  • Asendin (amoxapine) is not a first choice medicine for depression because of side effects.
  • In some people, Asendin (amoxapine) can stop working as early as 2-3 months after you start taking it.
  • Not recommended in older people, children under 16, or people who've had a history of seizures.
  • You might not notice changes in your mood until you've taken Surmontil (trimipramine) for several weeks.
  • Stopping Surmontil (trimipramine) suddenly without telling your doctor can be dangerous.
  • Surmontil (trimipramine) can cause more side effects than other medicines used to treat depression.
Used for
Dosage forms
  • Pill
  • Pill
Price
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$19.44
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Lowest price near you
$78.8
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Reviews
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Side effects
4possible side effects
  • Drowsiness or fatigue
    14%
  • Dry mouth
    14%
  • Constipation
    12%
  • Vision changes
    7%
See more detailed side effects
The Surmontil (trimipramine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Increased risk of suicide

    People under age 24

  • Vision changes

    Glaucoma

  • Neuroleptic malignant syndrome

    Taking antidepressants

  • Slowed breathing

    Taking opioids for pain relief or medicines for anxiety

  • Anticholinergic effects/Dehydration

    Over age 65

See more detailed risks and warnings
  • Higher risk of suicide

    People under age 24

  • Serotonin syndrome

    Tricyclic antidepressants

    ...and 6 more risk factors

  • Heart problems

    History of heart disease

See more detailed risks and warnings