Compare amoxapine vs. Tofranil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Asendin
(amoxapine)

Tofranil
(imipramine hydrochloride)

Stabilizes your mood. While Asendin (amoxapine) can treat depression, you have to take it several times a day and it can make you feel sleepy.Improves your mood and stops bedwetting in children. Tofranil (imipramine hydrochloride) is one of the first choice medicines used to treat depression, but it can cause weight gain and sleepiness.
Reviews & ratings
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Have you used Asendin (amoxapine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Tofranil (imipramine hydrochloride)?
Worth itNot sureNot worth it
Side effects
amoxapineTofranil
  • Drowsiness or fatigue 14%
  • Dry mouth 14%
  • Constipation 12%
  • Vision changes 7%
More amoxapine side effects »

The Tofranil FDA package insert doesn’t have numbers about how common side effects are.

More about Tofranil side effects »
How it works
amoxapineTofranil
Asendin (amoxapine) is a tricyclic antidepressant. It increases the activity of serotonin and norepinephrine in your brain which regulate your mood.Tofranil (imipramine hydrochloride) is a tricyclic antidepressant. It raises the amount of serotonin and norepinephrine in the brain, 2 chemicals that are known to regulate mood. It's not known exactly how Tofranil (imipramine hydrochloride) treats bedwetting.
Type of medication
amoxapineTofranil
Prescription onlyPrescription only
Available as
amoxapineTofranil
  • Pill
  • Pill
Used for
amoxapineTofranil
Risk factors for serious side effects
amoxapineTofranil
  • People under age 24
  • Glaucoma
  • Taking antidepressants
  • Taking opioids for pain relief or medicines for anxiety
  • Over age 65
Detailed Asendin (amoxapine) risks & warnings »
  • Under age 24
  • History of heart disease
  • Overactive thyroid
  • High blood pressure
  • History of seizures
Detailed Tofranil (imipramine hydrochloride) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
amoxapineTofranil
No alcohol related info.
  • Don't drink alcohol while taking Tofranil (imipramine hydrochloride).
Food
amoxapineTofranil
  • Take Asendin (amoxapine) with food to avoid stomach upset.
No food related info.
Sleep
amoxapineTofranil
  • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Tofranil (imipramine hydrochloride) can make you feel sleepy, so don't drive or do anything requiring concentration until you know how it affects you.
Weight
amoxapineTofranil
No weight related info.
  • Compared to other medicines for depression, Tofranil (imipramine hydrochloride) can make you more likely to gain weight and have changes in blood sugar. If you have diabetes, your doctor might need to change the doses of your medications to make sure your blood sugar stays controlled. Talk to your doctor to see if you should take another medicine besides Tofranil (imipramine hydrochloride).
Upsides and benefits
amoxapineTofranil
  • Asendin (amoxapine) can be used to treat more severe forms of depression.
  • Compared to similar medicines, Asendin (amoxapine) improves the mood in depression more quickly.
  • Asendin (amoxapine) is available as generic.
  • Tofranil (imipramine hydrochloride) is part of the first choice of medicines used to treat depression.
  • Available in generic.
  • Tofranil (imipramine hydrochloride) is usually taken only once a day.
  • Available in 3 different strengths.
Downsides and risks
amoxapineTofranil
  • Asendin (amoxapine) is not a first choice medicine for depression because of side effects.
  • In some people, Asendin (amoxapine) can stop working as early as 2-3 months after you start taking it.
  • Not recommended in older people, children under 16, or people who've had a history of seizures.
  • Tofranil (imipramine hydrochloride) can lower your sex drive and cause more weight gain than other similar medicines for depression.
  • You might be more sensitive to the sun and have a higher risk for heat stroke while taking Tofranil (imipramine hydrochloride).
  • If you have a history of heart conditions, your symptoms might get worse with Tofranil (imipramine hydrochloride). Talk to your doctor to see if Tofranil (imipramine hydrochloride) is right for you.
Tips from our pharmacists for people taking the medication
amoxapineTofranil
  • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • You might not notice any changes in your mood for at least a few weeks.
  • Take Asendin (amoxapine) with food to avoid stomach upset.
  • You're more likely to be dehydrated and constipated. Drink plenty of fluids and be careful not to get overheated if you're out in the sun.
  • Don't stop taking Asendin (amoxapine) without talking to your doctor. Stopping Asendin (amoxapine) suddenly can be very dangerous.
  • You might need to take Tofranil (imipramine hydrochloride) for a few weeks before you notice any changes in your mood.
  • Don't drink alcohol while taking Tofranil (imipramine hydrochloride).
  • If you miss your bedtime dose, skip it and take your regular dose the next evening. Don't take extra medicine to make up for the missed dose.
  • You might be more sensitive to the sun while taking Tofranil (imipramine hydrochloride). Make sure to drink plenty of liquids, wear sunscreen, or cover your skin if you'll be out in the sun.
  • Tofranil (imipramine hydrochloride) can make you feel sleepy, so don't drive or do anything requiring concentration until you know how it affects you.
  • Don't stop taking Tofranil (imipramine hydrochloride) without talking to your doctor first.
Learn more
More about amoxapineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Asendin (amoxapine)?
Worth itNot sureNot worth it
More about TofranilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tofranil (imipramine hydrochloride)?
Worth itNot sureNot worth it