Compare Amoxicillin vs. Augmentin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Amoxil
(Amoxicillin)

Augmentin
(Amoxicillin / Clavulanate)

Treats bacterial infections. Amoxil (Amoxicillin) is a good and cheap antibiotic to treat many types of bacterial infections. However, many bacteria are resistant to this medication.Kills bacteria. Augmentin (Amoxicillin / Clavulanate) is good for treating many bacterial infections and is available as generic. However, it will make birth control pills less effective. It also has to be taken with food since it can cause an upset stomach.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5Amoxicillin
Reviews for Amoxil (Amoxicillin)
62%
of people (All ages) say Amoxil (Amoxicillin) is worth it
45%
say it works well
14%
say it's a big hassle
786 reviews
Have you used Amoxil (Amoxicillin)?
Worth itNot sureNot worth it
Reviews for Augmentin (Amoxicillin / Clavulanate)
68%
+6% vs. Amoxil (Amoxicillin)
52%
+7% vs. Amoxil (Amoxicillin)
13%
+1% vs. Amoxil (Amoxicillin)
1034 reviews
Have you used Augmentin (Amoxicillin / Clavulanate)?
Worth itNot sureNot worth it
Side effects
AmoxicillinAugmentin

The Amoxicillin FDA package insert doesn’t have numbers about how common side effects are.

More about Amoxicillin side effects »

The Augmentin FDA package insert doesn’t have numbers about how common side effects are.

More about Augmentin side effects »
How it works
AmoxicillinAugmentin
Amoxil (Amoxicillin) is an antibiotic. It kills bacteria and prevents them from reproducing and making their own protective covering.Augmentin (Amoxicillin / Clavulanate) is a combination antibiotic. Amoxicillin kills bacteria and prevents them from reproducing and making their own protective covering. Clavulanate stops chemicals the bacteria make to resist antibiotics.
Type of medication
AmoxicillinAugmentin
Antibiotic
Penicillin
Prescription only
Antibiotic
Penicillin
Prescription only
Available as
AmoxicillinAugmentin
  • Pill
  • Chewable tablet
  • Liquid
  • Pill
  • Chewable tablet
  • Extended release
  • Liquid
Used for (click to learn more)
AmoxicillinAugmentin
Risk factors for serious side effects
AmoxicillinAugmentin
  • Long antibiotic treatment period
  • History of penicillin allergies
  • Using oral birth control pills
Detailed risks & warnings »
  • Mononucleosis
  • History of liver disease
Detailed risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Food
AmoxicillinAugmentin
  • Take with food to decrease upsetting your stomach (nausea, vomiting).
  • Should be taken with food since it can cause stomach upset.
  • Take each dose with a meal since it may cause an upset stomach.
Kidneys and liver
AmoxicillinAugmentin
No kidneys and liver related info.
  • There have been reports of liver damage that can require hospitalization or can cause death. These have been rare. Talk to your doctor if you notice pain in your abdomen, loss of appetite, yellowing of your skin or eyes, or dark colored urine.
Upsides and benefits
AmoxicillinAugmentin
  • Available in generic.
  • Available in different forms: tablet, capsule, and suspension.
  • Used to treat many types of bacterial infections.
  • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
  • Available in generic.
  • Available in different forms: tablet, capsule, and suspension.
  • Used to treat many types of bacterial infections.
Downsides and risks
AmoxicillinAugmentin
  • Suspension must be stored in the fridge.
  • Can make birth control pills and live vaccines less effective.
  • Many bacteria have developed resistance to this antibiotic.
  • Can cause diarrhea.
  • If you're on birth control pills, you should use a barrier method (condoms, diaphragms) since Augmentin can make them less effective.
  • Should be taken with food since it can cause stomach upset.
  • If you have phenylketonuria (PKU), talk to your doctor to prescribe an alternative.
Tips from our pharmacists for people taking the medication
AmoxicillinAugmentin
  • Finish all of the medicine your doctor gives you, even if you start to feel better. Stopping it early can cause the bacteria to develop resistance, making the medicine ineffective.
  • If you're taking birth control pills, this medication may make them less effective.
  • Take with food to decrease upsetting your stomach (nausea, vomiting).
  • If you're giving the suspension, you can mix it with a cold drink, but make sure to take it right away.
  • Keep the suspension form in the fridge. All other forms should be kept at room temperature.
  • You may have loose stool when taking this medicine, but it should get better soon after finishing the course. If the diarrhea worsens, tell your doctor.
  • Take this medication exactly as your doctor tells you to.
  • Take each dose with a meal since it may cause an upset stomach.
  • If you are taking birth control pills, this can make it less effective.
  • Store the suspension in the refrigerator. All other forms can be kept at room temperature.
Learn more
More about AmoxicillinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Amoxil (Amoxicillin)?
Worth itNot sureNot worth it
More about AugmentinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Augmentin (Amoxicillin / Clavulanate)?
Worth itNot sureNot worth it