Compare amoxicillin vs. Augmentin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Amoxil
(amoxicillin)

Augmentin
(amoxicillin / clavulanate)

Treats bacterial infections. Amoxil (amoxicillin) is a good and cheap antibiotic that comes in different forms to treat many types of bacterial infections.Treats bacterial infections. Augmentin (amoxicillin / clavulanate) is first-choice antibiotic for most common types of infections. However, it may not work against more serious or uncommon types of infections.
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Best available price for 30 (500mg) capsules of amoxicillin
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Reviews & ratings
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5amoxicillin
Reviews for Amoxil (amoxicillin)
62%
of people (All ages) say Amoxil (amoxicillin) is worth it
45%
say it works well
14%
say it's a big hassle
786 reviews
Have you used Amoxil (amoxicillin)?
Worth itNot sureNot worth it
Reviews for Augmentin (amoxicillin / clavulanate)
68%
+6% better vs. Amoxil (amoxicillin)
52%
+7% better vs. Amoxil (amoxicillin)
13%
+1% better vs. Amoxil (amoxicillin)
1034 reviews
Have you used Augmentin (amoxicillin / clavulanate)?
Worth itNot sureNot worth it
Side effects
amoxicillinAugmentin

The amoxicillin FDA package insert doesn’t have numbers about how common side effects are.

More about amoxicillin side effects »
  • Diarrhea 9%
  • Nausea 3%
  • Skin rash and hives 3%
More Augmentin side effects »
How it works
amoxicillinAugmentin
Amoxil (amoxicillin) is an antibiotic. It kills bacteria, and prevents them from reproducing and making their own protective covering.Augmentin (amoxicillin / clavulanate) contains two antibiotic medicines, which kill bacteria.
Type of medication
amoxicillinAugmentin
Prescription only
Prescription only
Available as
amoxicillinAugmentin
  • Pill
  • Chewable tablet
  • Extended-release tablet
  • Liquid
  • Pill
  • Chewable tablet
  • Extended release
  • Liquid
Used for
amoxicillinAugmentin
Risk factors for serious side effects
amoxicillinAugmentin
  • Taking Amoxil (amoxicillin) for a long time
  • Weakened immune system
  • Not taking Amoxil (amoxicillin) correctly
  • History of penicillin allergies
  • Using oral birth control pills
Detailed Amoxil (amoxicillin) risks & warnings »
  • History of penicillin allergies
  • Taking Augmentin (amoxicillin / clavulanate) for a long time
  • Mononucleosis
  • Using oral birth control pills
Detailed Augmentin (amoxicillin / clavulanate) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Food
amoxicillinAugmentin
  • Take with food to prevent upset stomach. If you're taking the extended-release version, take within 1 hour of finishing your meal.
  • Take with food if you're having upset stomach.
Kidneys and liver
amoxicillinAugmentin
No kidneys and liver related info.
  • Liver damage has been associated with patients taking Augmentin (amoxicillin / clavulanate). It's usually reversible, but deaths have been reported. Talk to your doctor if you notice pain in your abdomen, loss of appetite, yellowing of your skin or eyes, or dark colored urine.
Upsides and benefits
amoxicillinAugmentin
  • First choice medicine to treat many bacterial infections.
  • Available in generic.
  • Available in different forms: tablet, capsule, and liquid. The liquid comes in many different flavors to make it taste better for people who don't like pills.
  • Side effects are generally not too bad compared to other antibiotics.
  • Available as generic product.
  • Available in tablet, capsule, and liquid forms.
  • Used to treat most common types of bacterial infections.
  • Side effects are generally not too bad compared to other antibiotics.
Downsides and risks
amoxicillinAugmentin
  • While Amoxil (amoxicillin) can be used to treat different bacterial infections, many don't respond to it.
  • Can cause diarrhea, nausea, and vomiting.
  • Except for the extended-release form, you have to take Amoxil (amoxicillin) 2 to 3 times a day, which can be hard to remember.
  • The extended-release form can be more expensive because it's a brand name.
  • Many bacteria have developed resistance to this antibiotic.
  • Can cause diarrhea, nausea, and vomiting.
  • Birth control pills may not work as well to prevent pregnancy when taking this medication.
Tips from our pharmacists for people taking the medication
amoxicillinAugmentin
  • Finish all of the medicine, even if you start to feel better. Stopping Amoxil (amoxicillin) early can make the infection come back and harder to treat.
  • If you're on birth control, Amoxil (amoxicillin) might make it less effective. Talk to your doctor to see if you need to use backup.
  • Take with food to prevent upset stomach. If you're taking the extended-release version, take within 1 hour of finishing your meal.
  • If you have the liquid, keep the bottle in the fridge. The bottle is only good for 14 days after you pick it up. Shake the bottle well before using each dose.
  • You may have diarrhea or stomach upset when taking Amoxil (amoxicillin), but it should get better soon after you've finished. If the diarrhea gets worse, tell your doctor
  • Finish all of your medicine even if you start to feel better. Stopping it early can cause the infection to come back stronger than before.
  • Can make your oral birth control less effective. Consult your doctor or pharmacist if you need to use backup.
  • Take with food if you're having upset stomach.
  • Store the liquid in the fridge and throw away after 10 days.
  • Shake the suspension thoroughly before using each dose.
Learn more
More about amoxicillinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Amoxil (amoxicillin)?
Worth itNot sureNot worth it
More about AugmentinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Augmentin (amoxicillin / clavulanate)?
Worth itNot sureNot worth it