Compare Amoxicillin vs. Bactrim

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Amoxil
(Amoxicillin)

Bactrim
(Sulfamethoxazole / Trimethoprim)

Treats bacterial infections. Amoxil (Amoxicillin) is a good and cheap antibiotic to treat many types of bacterial infections. However, many bacteria are resistant to this medication.Kills bacteria. Bactrim (Sulfamethoxazole / Trimethoprim) is good for treating many bacterial infections and is available as a generic. However, you can be more likely to sunburn. Also, it can cause birth defects, so talk to your doctor if you're pregnant.
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Reviews & ratings
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5.0025641025641026Amoxicillin
Reviews for Amoxil (Amoxicillin)
62%
of people say Amoxil (Amoxicillin) is worth it
45%
say it works well
14%
say it's a big hassle
Reviews for Bactrim (Sulfamethoxazole / Trimethoprim)
59%
3% vs. Amoxil (Amoxicillin)
50%
+5% vs. Amoxil (Amoxicillin)
22%
8% vs. Amoxil (Amoxicillin)
Side effects
AmoxicillinBactrim

The Amoxicillin FDA package insert doesn’t have numbers about how common side effects are.

More about Amoxicillin side effects »

The Bactrim FDA package insert doesn’t have numbers about how common side effects are.

More about Bactrim side effects »
How it works
AmoxicillinBactrim
Amoxil (Amoxicillin) is an antibiotic. It kills bacteria and prevents them from reproducing and making their own protective covering.Bactrim (Sulfamethoxazole / Trimethoprim) is a combination antibiotic that contains sulfamethoxazole and trimethoprim. It kills bacteria by preventing them from making proteins and other chemicals that keep them alive.
Type of medication
AmoxicillinBactrim
Antibiotic
Penicillin
Prescription only
Antibiotic
Sulfonamide
Prescription only
Available as
AmoxicillinBactrim
  • Pill
  • Chewable tablet
  • Liquid
  • Pill
  • Liquid
Used for (click to learn more)
AmoxicillinBactrim
Risk factors for serious side effects
AmoxicillinBactrim
  • Long antibiotic treatment period
  • History of penicillin allergies
  • Using oral birth control pills
    Detailed Amoxil (Amoxicillin) risks & warnings »
            Detailed Bactrim (Sulfamethoxazole / Trimethoprim) risks & warnings »
            Pregnancy category
            AmoxicillinBactrim
            BFDA pregnancy category (Probably safe)

            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

            See the FDA package insert
            DFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            Alcohol
            No specific alcohol-related info.No specific alcohol-related info.
            Food
            • Take with food to decrease upsetting your stomach (nausea, vomiting).
            No specific food-related info.
            Kidneys and liver
            No specific kidneys and liver-related info.No specific kidneys and liver-related info.
            Sex
            No specific sex-related info.No specific sex-related info.
            Sleep
            No specific sleep-related info.No specific sleep-related info.
            Weight
            No specific weight-related info.No specific weight-related info.
            Upsides and benefits
            AmoxicillinBactrim
            • Available in different forms: tablet, capsule, and suspension.
            • Available in generic.
            • Used to treat many types of bacterial infections.
            • Available in different forms: tablet, capsule and suspension.
            • Less resistance seen to this antibiotic. Your doctor may run tests to see if Bactrim responds to your infection.
            • Available in generic.
            • Used to treat many types of bacterial infections.
            Downsides and risks
            AmoxicillinBactrim
            • Suspension must be stored in the fridge.
            • Can make birth control pills and live vaccines less effective.
            • Many bacteria have developed resistance to this antibiotic.
            • Can cause diarrhea.
            • Makes your skin more sensitive to the sun.
            • Has to be taken with plenty of liquids.
            • May cause birth defects.
            • Can cause diarrhea.
            Tips from our pharmacists for people taking the medication
            AmoxicillinBactrim
            • Finish all of the medicine your doctor gives you, even if you start to feel better. Stopping it early can cause the bacteria to develop resistance, making the medicine ineffective.
            • If you're taking birth control pills, this medication may make them less effective.
            • Take with food to decrease upsetting your stomach (nausea, vomiting).
            • If you're giving the suspension, you can mix it with a cold drink, but make sure to take it right away.
            • Keep the suspension form in the fridge. All other forms should be kept at room temperature.
            • You may have loose stool when taking this medicine, but it should get better soon after finishing the course. If the diarrhea worsens, tell your doctor.
            • Take this medication exactly how your doctor tells you to.
            • Can make your skin more sensitive to the sun.
            • Drink plenty of liquids when taking the medication.
            • Can cause diarrhea, nausea or vomiting.
            • Can cause rash.
            Learn more
            More about AmoxicillinSide effectsReviews & ratingsAlternativesFDA package insert
            More about BactrimSide effectsReviews & ratingsAlternativesFDA package insert