Compare amoxicillin vs. Bactrim

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Amoxil
(amoxicillin)

Bactrim
(sulfamethoxazole / trimethoprim)

Treats bacterial infections. Amoxil (amoxicillin) is a good and cheap antibiotic that comes in different forms to treat many types of bacterial infections.Kills bacteria. Bactrim (sulfamethoxazole / trimethoprim) is good for treating many bacterial infections and is available as a generic. However, you can be more likely to sunburn.
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Prices and coupon for 30 (500mg) capsules of amoxicillin
Coupons for
Prices and coupon for 20 (800mg/160mg) tablets of sulfamethoxazole / trimethoprim
Reviews & ratings
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5amoxicillin
Reviews for Amoxil (amoxicillin)
62%
of people (All ages) say Amoxil (amoxicillin) is worth it
45%
say it works well
14%
say it's a big hassle
786 reviews
Have you used Amoxil (amoxicillin)?
Worth itNot sureNot worth it
Reviews for Bactrim (sulfamethoxazole / trimethoprim)
59%
-3% worse vs. Amoxil (amoxicillin)
49%
+4% better vs. Amoxil (amoxicillin)
22%
-8% worse vs. Amoxil (amoxicillin)
473 reviews
Have you used Bactrim (sulfamethoxazole / trimethoprim)?
Worth itNot sureNot worth it
Side effects
amoxicillinBactrim

The amoxicillin FDA package insert doesn’t have numbers about how common side effects are.

More about amoxicillin side effects »

The Bactrim FDA package insert doesn’t have numbers about how common side effects are.

More about Bactrim side effects »
How it works
amoxicillinBactrim
Amoxil (amoxicillin) is an antibiotic. It kills bacteria, and prevents them from reproducing and making their own protective covering.Bactrim (sulfamethoxazole / trimethoprim) is a combination antibiotic that contains sulfamethoxazole and trimethoprim. It kills bacteria.
Type of medication
amoxicillinBactrim
Prescription only
Prescription only
Available as
amoxicillinBactrim
  • Pill
  • Chewable tablet
  • Extended-release tablet
  • Liquid
  • Pill
  • Liquid
Used for
amoxicillinBactrim
Risk factors for serious side effects
amoxicillinBactrim
  • Taking Amoxil (amoxicillin) for a long time
  • Weakened immune system
  • Not taking Amoxil (amoxicillin) correctly
  • History of penicillin allergies
  • Using oral birth control pills
  • Mononucleosis
Detailed Amoxil (amoxicillin) risks & warnings »
          • Elderly
          • Taking other medicines that lower kidney function
          Detailed Bactrim (sulfamethoxazole / trimethoprim) risks & warnings »
          Pregnancy

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Food
          amoxicillinBactrim
          • Take with food to prevent upset stomach. If you're taking the extended-release version, take within 1 hour of finishing your meal.
          No food related info.
          Kidneys and liver
          amoxicillinBactrim
          No kidneys and liver related info.
          • Bactrim (sulfamethoxazole / trimethoprim) can harm your kidneys, especially if you're taking anti-inflammatory pain relievers like Motrin or Advil or other medicines that also affect your kidneys. Make sure to drink plenty of water or fluids while you're taking Bactrim (sulfamethoxazole / trimethoprim).
          Upsides and benefits
          amoxicillinBactrim
          • First choice medicine to treat many bacterial infections.
          • Available in generic.
          • Available in different forms: tablet, capsule, and liquid. The liquid comes in many different flavors to make it taste better for people who don't like pills.
          • Side effects are generally not too bad compared to other antibiotics.
          • Widely available as a generic product and in a variety of formulations (tablet, capsule, suspension).
          • Works well to treat many types of bacterial infections
          Downsides and risks
          amoxicillinBactrim
          • While Amoxil (amoxicillin) can be used to treat different bacterial infections, many don't respond to it.
          • Can cause diarrhea, nausea, and vomiting.
          • Except for the extended-release form, you have to take Amoxil (amoxicillin) 2 to 3 times a day, which can be hard to remember.
          • The extended-release form can be more expensive because it's a brand name.
          • Makes you sensitive to the sun.
          • Can upset your stomach
          • Drink plenty of water or fluids to avoid harming your kidneys
          • May cause birth defects
          Tips from our pharmacists for people taking the medication
          amoxicillinBactrim
          • Finish all of the medicine, even if you start to feel better. Stopping Amoxil (amoxicillin) early can make the infection come back and harder to treat.
          • If you're on birth control, Amoxil (amoxicillin) might make it less effective. Talk to your doctor to see if you need to use backup.
          • Take with food to prevent upset stomach. If you're taking the extended-release version, take within 1 hour of finishing your meal.
          • If you have the liquid, keep the bottle in the fridge. The bottle is only good for 14 days after you pick it up. Shake the bottle well before using each dose.
          • You may have diarrhea or stomach upset when taking Amoxil (amoxicillin), but it should get better soon after you've finished. If the diarrhea gets worse, tell your doctor
          • Take Bactrim (sulfamethoxazole / trimethoprim) exactly the way your doctor tells you.
          • Can make you more sensitive to the sun. Keep out of the sun or wear protection while under the sun.
          • Drink plenty of water or liquids while on Bactrim (sulfamethoxazole / trimethoprim) to avoid harming your kidneys.
          • Can cause upset stomach.
          • Can cause an allergic reaction. Talk to your doctor if you notice skin rash or swelling of your face.
          Learn more
          More about amoxicillinSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Amoxil (amoxicillin)?
          Worth itNot sureNot worth it
          More about BactrimSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Bactrim (sulfamethoxazole / trimethoprim)?
          Worth itNot sureNot worth it