Compare Amoxicillin vs. Benzamycin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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(Benzoyl Peroxide / Erythromycin)

Treats bacterial infections. Amoxil (Amoxicillin) is a good and cheap antibiotic to treat many types of bacterial infections. However, many bacteria are resistant to this medication.Topical treatment for acne. Benzamycin (Benzoyl Peroxide / Erythromycin) is a topical combination acne treatment that may work better for people who didn't see an improvement when taking either medicine alone or simply don't want to take pill medication. You need to be careful because it can bleach your hair, clothing and other fabrics. It also needs to be stored in the refrigerator and is only good for three months..
How it works
Amoxil (Amoxicillin) is an antibiotic. It kills bacteria and prevents them from reproducing and making their own protective covering.Benzamycin (Benzoyl Peroxide / Erythromycin) is a combination topical medicine. Erythromycin (an antibiotic) kills bacteria that cause acne. Benzoyl peroxide works to fight the bacteria and shed acne-affected skin.
Type of medication
Prescription only
Acne agent
Prescription only
Available as
  • Pill
  • Chewable tablet
  • Liquid
  • Cream, gel, or ointment
Used for (click to learn more)
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
Reviews for Amoxil (Amoxicillin)
of people say Amoxil (Amoxicillin) is worth it
say it works well
say it's a big hassle
Reviews for Benzamycin (Benzoyl Peroxide / Erythromycin)
8% vs. Amoxil (Amoxicillin)
19% vs. Amoxil (Amoxicillin)
+2% vs. Amoxil (Amoxicillin)
Side effects

The Amoxicillin FDA package insert doesn’t have numbers about how common side effects are.

More about Amoxicillin side effects »

The Benzamycin FDA package insert doesn’t have numbers about how common side effects are.

More about Benzamycin side effects »
Risk factors for serious side effects
  • Long antibiotic treatment period
  • History of penicillin allergies
  • Using oral birth control pills
    Detailed Amoxil (Amoxicillin) risks & warnings »
      • Using other medicines or products that irritate the skin
      • Eczema
      • Extreme temperatures (hot or cold)
        • Long-term use of Benzamycin (Benzoyl Peroxide / Erythromycin)
        Detailed Benzamycin (Benzoyl Peroxide / Erythromycin) risks & warnings »
        Pregnancy category
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        No specific alcohol-related info.No specific alcohol-related info.
        • Take with food to decrease upsetting your stomach (nausea, vomiting).
        No specific food-related info.
        Kidneys and liver
        No specific kidneys and liver-related info.No specific kidneys and liver-related info.
        No specific sex-related info.No specific sex-related info.
        No specific sleep-related info.No specific sleep-related info.
        No specific weight-related info.
        • Not the best choice if you're pregnant. Benzamycin is categorized as pregnancy Category C (weight risks vs benefits) because of the benzoyl peroxide part.
        Upsides and benefits
        • Available in generic.
        • Available in different forms: tablet, capsule, and suspension.
        • Used to treat many types of bacterial infections.
        • Benzamycin works better to reduce bacteria in oil glands and improve overall signs and symptoms of acne than either medicine alone.
        • Reduces bacteria on the skin, which "calms" the skin down (lowers the inflammatory response) in acne.
        • Combining an antibiotic with benzoyl peroxide lowers the chances of Benzamycin not working as well over time.
        • Although Benzamycin can irritate the skin, a true skin allergy is rare.
        • Can be used in combination with acne pill medicine if your doctor thinks you need it.
        Downsides and risks
        • Suspension must be stored in the fridge.
        • Can make birth control pills and live vaccines less effective.
        • Many bacteria have developed resistance to this antibiotic.
        • Can cause diarrhea.
        • There's a risk of irritation with anything you apply to your skin and this is no different. Benzamycin, contains a topical antibiotic and can cause redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
        • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas
        • Can cause severe inflammation of the large intestine (pseudomembranous colitis).
        • Not the best choice if you're pregnant. Benzamycin is categorized as pregnancy Category C (weight risks vs benefits) because of the benzoyl peroxide part.
        • Can cause bleaching of hair and clothing.
        • You'll need to stay out of the sun or apply a sunscreen if you go outdoors.
        Tips from our pharmacists for people taking the medication
        • Finish all of the medicine your doctor gives you, even if you start to feel better. Stopping it early can cause the bacteria to develop resistance, making the medicine ineffective.
        • If you're taking birth control pills, this medication may make them less effective.
        • Take with food to decrease upsetting your stomach (nausea, vomiting).
        • If you're giving the suspension, you can mix it with a cold drink, but make sure to take it right away.
        • Keep the suspension form in the fridge. All other forms should be kept at room temperature.
        • You may have loose stool when taking this medicine, but it should get better soon after finishing the course. If the diarrhea worsens, tell your doctor.
        • Combination medicine you apply to your skin to treat acne.
        • Apply a thin film to clean and dry affected skin twice a day- in the morning and evening.
        • Store in the refrigerator, but don't freeze.
        • The pharmacist mixes the medicine when you pick it up at the drugstore. You'll need to use it within three months of this date or dispose of it properly.
        • Let your doctor know if you notice abdominal discomfort, pain or diarrhea after starting this medicine.
        • Using a moisturizer that doesn't block your pores (non-comedogenic) may help lessen common side effects of skin dryness and peeling.
        • Taking good care of your skin is an important part of treating acne. Lightly wash with warm water and non-soap-based or gentle cleanser.
        Learn more
        More about AmoxicillinSide effectsReviews & ratingsAlternativesFDA package insert
        More about BenzamycinSide effectsReviews & ratingsAlternativesFDA package insert