Compare amoxicillin vs. Cipro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Amoxil
(amoxicillin)

Cipro
(ciprofloxacin)

Treats bacterial infections. Amoxil (amoxicillin) is a good and cheap antibiotic that comes in different forms to treat many types of bacterial infections.Kills bacteria. Cipro (Ciprofloxacin) is a good and cheap antibiotic to treat many types of bacterial infections. However, you have to reduce your caffeine intake, and have to protect yourself from the sun.
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Coupons for amoxicillin
Best available price for 30 (500mg) capsules of amoxicillin
Coupons for Cipro
Best available price for 20 (500mg) tablets of ciprofloxacin
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5amoxicillin
Reviews for amoxicillin
62%
of people (All ages) say amoxicillin is worth it
45%
say it works well
14%
say it's a big hassle
786 reviews
Have you used Amoxil (amoxicillin)?
Worth itNot sureNot worth it
Reviews for Cipro
63%
-1% worse vs. amoxicillin
53%
-8% worse vs. amoxicillin
17%
+3% better vs. amoxicillin
755 reviews
Have you used Cipro (ciprofloxacin)?
Worth itNot sureNot worth it
Side effects
amoxicillinCipro

The amoxicillin FDA package insert doesn’t have numbers about how common side effects are.

More about amoxicillin side effects »
  • Any musculosketal side effect 14%
  • Any side effect 41%
  • Any musculoskeletal side effect 9%
  • Any neurological side effect 3%
  • Nausea 3%
  • Diarrhea 2%
  • Any gastrointestinal side effect 15%
  • Any serious side effect 8%
  • Vomiting 5%
  • Abdominal pain 3%
More Cipro side effects »
How it works
amoxicillinCipro
Amoxil (amoxicillin) is an antibiotic. It kills bacteria, and prevents them from reproducing and making their own protective covering.Cipro (Ciprofloxacin) is an antibiotic. It kills bacteria by preventing them from reproducing and repairing themselves.
Type of medication
amoxicillinCipro
Prescription onlyPrescription only
Available as
amoxicillinCipro
  • Pill
  • Chewable tablet
  • Extended-release tablet
  • Liquid
  • Pill
  • Extended release
  • Infusion (iv)
Used for
amoxicillinCipro
Risk factors for serious side effects
amoxicillinCipro
  • Taking Amoxil (amoxicillin) for a long time
  • Weakened immune system
  • Not taking Amoxil (amoxicillin) correctly
  • History of penicillin allergies
  • Using oral birth control pills
Detailed Amoxil (amoxicillin) risks & warnings »
  • Over 60 years of age
  • On long-term steroid use
  • Heart, kidney, or lung transplant
  • Myasthenia gravis
Detailed Cipro (ciprofloxacin) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
amoxicillinCipro
  • Take with food to prevent upset stomach. If you're taking the extended-release version, take within 1 hour of finishing your meal.
No food related info.
Pain
amoxicillinCipro
No pain related info.
  • If you notice redness/inflammation, pain or swelling in your joints or muscles, especially in the Achilles tendon, contact your doctor immediately.
  • Talk to your doctor immediately if you start to feel burning, tingling, numbness, pain or you can't tolerate heat or cold. This could be a sign of nerve damage and it can happen as soon as you start taking the medication and may not go away if you stop it.
  • If you notice pain in your Achilles tendons, contact your doctor.
Upsides and benefits
amoxicillinCipro
  • First choice medicine to treat many bacterial infections.
  • Available in generic.
  • Available in different forms: tablet, capsule, and liquid. The liquid comes in many different flavors to make it taste better for people who don't like pills.
  • Side effects are generally not too bad compared to other antibiotics.
  • Available in generic.
  • Available in different forms: tablet, capsule, and suspension.
  • Used to treat many types of bacterial infections.
  • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
Downsides and risks
amoxicillinCipro
  • While Amoxil (amoxicillin) can be used to treat different bacterial infections, many don't respond to it.
  • Can cause diarrhea, nausea, and vomiting.
  • Except for the extended-release form, you have to take Amoxil (amoxicillin) 2 to 3 times a day, which can be hard to remember.
  • The extended-release form can be more expensive because it's a brand name.
  • Must be used with caution in people over 60 years of age, or who have had either an organ transplant or on long-term steroid use due to possible tendon rupture.
  • If you have caffeine while on Ciprofloxacin, you may noticed increased effects of the caffeine.
  • Ciprofloxacin can make your skin more sensitive to the sun.
  • Can't be used if you've ever had myasthenia gravis.
  • Can cause diarrhea.
Tips from our pharmacists for people taking the medication
amoxicillinCipro
  • Finish all of the medicine, even if you start to feel better. Stopping Amoxil (amoxicillin) early can make the infection come back and harder to treat.
  • If you're on birth control, Amoxil (amoxicillin) might make it less effective. Talk to your doctor to see if you need to use backup.
  • Take with food to prevent upset stomach. If you're taking the extended-release version, take within 1 hour of finishing your meal.
  • If you have the liquid, keep the bottle in the fridge. The bottle is only good for 14 days after you pick it up. Shake the bottle well before using each dose.
  • You may have diarrhea or stomach upset when taking Amoxil (amoxicillin), but it should get better soon after you've finished. If the diarrhea gets worse, tell your doctor
  • If you notice pain in your Achilles tendons, contact your doctor.
  • Wear sunscreen if you're going to be out in the sun.
  • Take the medication exactly how the doctor tells you to.
  • Avoid taking this by itself with dairy products (milk, cheese, yogurt) or with juice with calcium.
  • Take this medication at least 2 hours before or 6 hours after any antacids with magnesium or aluminum or with any vitamins with calcium, iron or zinc.
  • Can cause diarrhea, nausea or vomiting.
  • Limit your caffeine intake while taking this medication.
Learn more
More about amoxicillinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Amoxil (amoxicillin)?
Worth itNot sureNot worth it
More about CiproSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Cipro (ciprofloxacin)?
Worth itNot sureNot worth it