Compare Amoxicillin vs. Cleocin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Amoxil
(Amoxicillin)

Cleocin T
(Clindamycin Phosphate)

Treats bacterial infections. Amoxil (Amoxicillin) is a good and cheap antibiotic to treat many types of bacterial infections. However, many bacteria are resistant to this medication.Topical treatment for acne. Cleocin T (Clindamycin Phosphate) is good for treating many bacterial infections and is available as a generic. If you're taking the vaginal form, you have to avoid sex and tampons for the period your doctor tells you to. The topical form can cause skin sensitivity and irritation.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.0025641025641026Amoxicillin
Reviews for Amoxil (Amoxicillin)
62%
of people say Amoxil (Amoxicillin) is worth it
45%
say it works well
14%
say it's a big hassle
Reviews for Cleocin T (Clindamycin Phosphate)
57%
5% vs. Amoxil (Amoxicillin)
43%
2% vs. Amoxil (Amoxicillin)
20%
6% vs. Amoxil (Amoxicillin)
Side effects
AmoxicillinCleocin

The Amoxicillin FDA package insert doesn’t have numbers about how common side effects are.

More about Amoxicillin side effects »
  • Vaginal moniliasis 6%
More Cleocin side effects »
How it works
AmoxicillinCleocin
Amoxil (Amoxicillin) is an antibiotic. It kills bacteria and prevents them from reproducing and making their own protective covering.Cleocin T (Clindamycin Phosphate) is an antibiotic and acne medicine. It kills bacteria by preventing them from reproducing and repairing themselves.
Type of medication
AmoxicillinCleocin
Antibiotic
Penicillin
Prescription only
Acne agent
Antibiotic
Prescription only
Available as
AmoxicillinCleocin
  • Pill
  • Chewable tablet
  • Liquid
  • Topical
  • Cream, gel, or ointment
  • Foam
  • Vaginal cream
  • Vaginal suppository
  • Injection
Used for (click to learn more)
AmoxicillinCleocin
Risk factors for serious side effects
AmoxicillinCleocin
  • Long antibiotic treatment period
  • History of penicillin allergies
  • Using oral birth control pills
    Detailed Amoxil (Amoxicillin) risks & warnings »
      • History of liver disease
        Detailed Cleocin T (Clindamycin Phosphate) risks & warnings »
        Pregnancy category
        AmoxicillinCleocin
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.No specific alcohol-related info.
        Food
        • Take with food to decrease upsetting your stomach (nausea, vomiting).
        • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
        • Can be taken with or without food.
        Kidneys and liver
        No specific kidneys and liver-related info.No specific kidneys and liver-related info.
        Sex
        No specific sex-related info.
        • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
        • If you're using the vaginal form, don't have sex before the doctor tells you it's ok.
        Sleep
        No specific sleep-related info.No specific sleep-related info.
        Weight
        No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        AmoxicillinCleocin
        • Available in different forms: tablet, capsule, and suspension.
        • Available in generic.
        • Used to treat many types of bacterial infections.
        • Topical form treats acne.
        • Available in different oral forms: tablet, capsule, and suspension.
        • Available in forms to treat skin infections and vaginal infections.
        • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
        • Can be taken with or without food.
        • Available in generic.
        • Used to treat many types of bacterial infections.
        Downsides and risks
        AmoxicillinCleocin
        • Suspension must be stored in the fridge.
        • Can make birth control pills and live vaccines less effective.
        • Many bacteria have developed resistance to this antibiotic.
        • Can cause diarrhea.
        • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
        • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
        • If you're allergic to aspirin, your doctor may have to prescribe an alternate.
        • If you have to take live vaccines, talk to your doctor when to take them since Clindamycin can make it less effective.
        • If you're taking the topical form, it can cause sensitivity and irritation.
        Tips from our pharmacists for people taking the medication
        AmoxicillinCleocin
        • Finish all of the medicine your doctor gives you, even if you start to feel better. Stopping it early can cause the bacteria to develop resistance, making the medicine ineffective.
        • If you're taking birth control pills, this medication may make them less effective.
        • Take with food to decrease upsetting your stomach (nausea, vomiting).
        • If you're giving the suspension, you can mix it with a cold drink, but make sure to take it right away.
        • Keep the suspension form in the fridge. All other forms should be kept at room temperature.
        • You may have loose stool when taking this medicine, but it should get better soon after finishing the course. If the diarrhea worsens, tell your doctor.
        • The forms taken by mouth can cause diarrhea, vomiting, and abdominal pain.
        • Take this medication exactly how your doctor tells you to.
        • Store the suspension at room temperature.
        • If you're using the topical form, it can take a few weeks to see the full effect.
        • Keep the topical form out of your eyes, nose and mouth.
        • If you're using the topical form, Don't put makeup or bandages over it.
        • If you're using the vaginal form, don't have sex before the doctor tells you it's ok.
        Learn more
        More about AmoxicillinSide effectsReviews & ratingsAlternativesFDA package insert
        More about CleocinSide effectsReviews & ratingsAlternativesFDA package insert