Compare amoxicillin vs. Cleocin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Amoxil
(amoxicillin)

Cleocin T
(clindamycin phosphate)

Treats bacterial infections. Amoxil (amoxicillin) is a good and cheap antibiotic that comes in different forms to treat many types of bacterial infections.Topical treatment for acne. Cleocin T (Clindamycin Phosphate) is good for treating many bacterial infections and is available as a generic. If you're taking the vaginal form, you have to avoid sex and tampons for the period your doctor tells you to. The topical form can cause skin sensitivity and irritation.
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Prices and coupon for 30 (500mg) capsules of amoxicillin
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Reviews & ratings
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5amoxicillin
Reviews for Amoxil (amoxicillin)
62%
of people (All ages) say Amoxil (amoxicillin) is worth it
45%
say it works well
14%
say it's a big hassle
786 reviews
Have you used Amoxil (amoxicillin)?
Worth itNot sureNot worth it
Reviews for Cleocin T (clindamycin phosphate)
57%
-5% worse vs. Amoxil (amoxicillin)
43%
-2% worse vs. Amoxil (amoxicillin)
19%
-5% worse vs. Amoxil (amoxicillin)
115 reviews
Have you used Cleocin T (clindamycin phosphate)?
Worth itNot sureNot worth it
Side effects
amoxicillinCleocin

The amoxicillin FDA package insert doesn’t have numbers about how common side effects are.

More about amoxicillin side effects »
  • Any side effect 21%
  • Vaginal moniliasis 8%
  • Vulvovaginitis 6%
  • Vulvovaginal disorder 3%
  • Moniliasis (body) 2%
  • Fungal infection 2%
More Cleocin side effects »
How it works
amoxicillinCleocin
Amoxil (amoxicillin) is an antibiotic. It kills bacteria, and prevents them from reproducing and making their own protective covering.Cleocin T (Clindamycin Phosphate) is an antibiotic and acne medicine. It kills bacteria by preventing them from reproducing and repairing themselves.
Type of medication
amoxicillinCleocin
Prescription only
Prescription only
Available as
amoxicillinCleocin
  • Pill
  • Chewable tablet
  • Extended-release tablet
  • Liquid
  • Topical
  • Cream, gel, or ointment
  • Foam
  • Vaginal cream
  • Vaginal suppository
  • Injection
Used for
amoxicillinCleocin
Risk factors for serious side effects
amoxicillinCleocin
  • Taking Amoxil (amoxicillin) for a long time
  • Weakened immune system
  • Not taking Amoxil (amoxicillin) correctly
  • History of penicillin allergies
  • Using oral birth control pills
  • Mononucleosis
Detailed Amoxil (amoxicillin) risks & warnings »
    • History of liver disease
      Detailed Cleocin T (clindamycin phosphate) risks & warnings »
      Pregnancy

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Food
      amoxicillinCleocin
      • Take with food to prevent upset stomach. If you're taking the extended-release version, take within 1 hour of finishing your meal.
      • Can be taken with or without food.
      Kidneys and liver
      amoxicillinCleocin
      No kidneys and liver related info.
      • There have been reports of liver damage that can require hospitalization or can cause death. These have been rare. Talk to your doctor if you notice pain in your abdomen, loss of appetite, yellowing of your skin or eyes, or dark colored urine.
      Pain
      amoxicillinCleocin
      No pain related info.
      • The forms taken by mouth can cause diarrhea, vomiting, and abdominal pain.
      Upsides and benefits
      amoxicillinCleocin
      • First choice medicine to treat many bacterial infections.
      • Available in generic.
      • Available in different forms: tablet, capsule, and liquid. The liquid comes in many different flavors to make it taste better for people who don't like pills.
      • Side effects are generally not too bad compared to other antibiotics.
      • Available in generic.
      • Topical form treats acne.
      • Available in different oral forms: tablet, capsule, and suspension.
      • Available in forms to treat skin infections and vaginal infections.
      • Used to treat many types of bacterial infections.
      • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
      • Can be taken with or without food.
      Downsides and risks
      amoxicillinCleocin
      • While Amoxil (amoxicillin) can be used to treat different bacterial infections, many don't respond to it.
      • Can cause diarrhea, nausea, and vomiting.
      • Except for the extended-release form, you have to take Amoxil (amoxicillin) 2 to 3 times a day, which can be hard to remember.
      • The extended-release form can be more expensive because it's a brand name.
      • Have to take the oral forms with a full glass of liquid or with food since it can cause irritation in your stomach and esophagus.
      • If you're taking the vaginal form, you have to avoid sex and not use tampons for the period your doctor tells you to.
      • If you're allergic to aspirin, your doctor may have to prescribe an alternate.
      • If you have to take live vaccines, talk to your doctor when to take them since Clindamycin can make it less effective.
      • If you're taking the topical form, it can cause sensitivity and irritation.
      Tips from our pharmacists for people taking the medication
      amoxicillinCleocin
      • Finish all of the medicine, even if you start to feel better. Stopping Amoxil (amoxicillin) early can make the infection come back and harder to treat.
      • If you're on birth control, Amoxil (amoxicillin) might make it less effective. Talk to your doctor to see if you need to use backup.
      • Take with food to prevent upset stomach. If you're taking the extended-release version, take within 1 hour of finishing your meal.
      • If you have the liquid, keep the bottle in the fridge. The bottle is only good for 14 days after you pick it up. Shake the bottle well before using each dose.
      • You may have diarrhea or stomach upset when taking Amoxil (amoxicillin), but it should get better soon after you've finished. If the diarrhea gets worse, tell your doctor
      • The forms taken by mouth can cause diarrhea, vomiting, and abdominal pain.
      • Take this medication exactly how your doctor tells you to.
      • Store the suspension at room temperature.
      • If you're using the topical form, it can take a few weeks to see the full effect.
      • Keep the topical form out of your eyes, nose and mouth.
      • If you're using the topical form, Don't put makeup or bandages over it.
      • If you're using the vaginal form, don't have sex before the doctor tells you it's ok.
      Learn more
      More about amoxicillinSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Amoxil (amoxicillin)?
      Worth itNot sureNot worth it
      More about CleocinSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Cleocin T (clindamycin phosphate)?
      Worth itNot sureNot worth it