Compare Amoxicillin vs. Doxycycline

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Amoxil
(Amoxicillin)

Vibramycin
(Doxycycline)

Treats bacterial infections. Amoxil (Amoxicillin) is a good and cheap antibiotic to treat many types of bacterial infections. However, many bacteria are resistant to this medication.Treats bacterial infections. Vibramycin (Doxycycline) is good for treating many bacterial infections. It is also available as generic. However, it can make birth control pills less effective. You also have to protect yourself against sunburn.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.0025641025641026Amoxicillin
Reviews for Amoxil (Amoxicillin)
62%
of people say Amoxil (Amoxicillin) is worth it
45%
say it works well
14%
say it's a big hassle
Reviews for Vibramycin (Doxycycline)
50%
12% vs. Amoxil (Amoxicillin)
34%
11% vs. Amoxil (Amoxicillin)
23%
9% vs. Amoxil (Amoxicillin)
Side effects
AmoxicillinDoxycycline

The Amoxicillin FDA package insert doesn’t have numbers about how common side effects are.

More about Amoxicillin side effects »

The Doxycycline FDA package insert doesn’t have numbers about how common side effects are.

More about Doxycycline side effects »
How it works
AmoxicillinDoxycycline
Amoxil (Amoxicillin) is an antibiotic. It kills bacteria and prevents them from reproducing and making their own protective covering.Vibramycin (Doxycycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.
Type of medication
AmoxicillinDoxycycline
Antibiotic
Penicillin
Prescription only
Antibiotic
Tetracycline
Prescription only
Available as
AmoxicillinDoxycycline
  • Pill
  • Chewable tablet
  • Liquid
  • Pill
  • Delayed release capsule
  • Liquid
Used for (click to learn more)
AmoxicillinDoxycycline
Risk factors for serious side effects
AmoxicillinDoxycycline
  • Long antibiotic treatment period
  • History of penicillin allergies
  • Using oral birth control pills
    Detailed Amoxil (Amoxicillin) risks & warnings »
    • Age 8 years or younger
    • Using oral birth control pills
    • Long antibiotic treatment period
        • Women of childbearing age
        • Women of childbearing age
        • Overweight or obese
        • Taking isotretinoin (Accutane)
        Detailed Vibramycin (Doxycycline) risks & warnings »
        Pregnancy category
        AmoxicillinDoxycycline
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        DFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.No specific alcohol-related info.
        Food
        • Take with food to decrease upsetting your stomach (nausea, vomiting).
        • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
        • Take with plenty of food and liquids.
        Kidneys and liver
        No specific kidneys and liver-related info.No specific kidneys and liver-related info.
        Sex
        No specific sex-related info.No specific sex-related info.
        Sleep
        No specific sleep-related info.No specific sleep-related info.
        Weight
        No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        AmoxicillinDoxycycline
        • Available in generic.
        • Available in different forms: tablet, capsule, and suspension.
        • Used to treat many types of bacterial infections.
        • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
        • Available in generic.
        • Available in different forms: tablet, capsule, and suspension.
        • Used to treat many types of bacterial infections.
        Downsides and risks
        AmoxicillinDoxycycline
        • Suspension must be stored in the fridge.
        • Can make birth control pills and live vaccines less effective.
        • Many bacteria have developed resistance to this antibiotic.
        • Can cause diarrhea.
        • Can't be used in pregnant women and children under 8 years old.
        • Makes your skin more sensitive to the sun.
        • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
        • Can make birth control less effective.
        • Can cause diarrhea.
        Tips from our pharmacists for people taking the medication
        AmoxicillinDoxycycline
        • Finish all of the medicine your doctor gives you, even if you start to feel better. Stopping it early can cause the bacteria to develop resistance, making the medicine ineffective.
        • If you're taking birth control pills, this medication may make them less effective.
        • Take with food to decrease upsetting your stomach (nausea, vomiting).
        • If you're giving the suspension, you can mix it with a cold drink, but make sure to take it right away.
        • Keep the suspension form in the fridge. All other forms should be kept at room temperature.
        • You may have loose stool when taking this medicine, but it should get better soon after finishing the course. If the diarrhea worsens, tell your doctor.
        • Take the medication exactly how your doctor tells you to.
        • If you're using birth control pills, this medication can make them less effective.
        • Wear sunblock if you have to go out into the sun since your skin can become more sensitive to sunburn.
        • Can cause diarrhea, nausea or vomiting.
        • Space out any vitamins by at least two hours.
        • Take with plenty of food and liquids.
        • Don't take any medications with bismuth (Pepto-Bismol, Kaopectate) while taking this medication.
        • Don't lie down for at least 30 minutes after taking this medication.
        Learn more
        More about AmoxicillinSide effectsReviews & ratingsAlternativesFDA package insert
        More about DoxycyclineSide effectsReviews & ratingsAlternativesFDA package insert