Compare amoxicillin vs. Doxycycline

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Amoxil
(amoxicillin)

Vibramycin
(doxycycline)

Treats bacterial infections. Amoxil (amoxicillin) is a good and cheap antibiotic that comes in different forms to treat many types of bacterial infections.Treats bacterial infections. Vibramycin (Doxycycline) is good for treating many bacterial infections. It is also available as generic. However, it can make birth control pills less effective. You also have to protect yourself against sunburn.
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Best available price for 30 (500mg) capsules of amoxicillin
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Reviews & ratings
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5amoxicillin
Reviews for Amoxil (amoxicillin)
62%
of people (All ages) say Amoxil (amoxicillin) is worth it
45%
say it works well
14%
say it's a big hassle
786 reviews
Have you used Amoxil (amoxicillin)?
Worth itNot sureNot worth it
Reviews for Vibramycin (doxycycline)
49%
-13% worse vs. Amoxil (amoxicillin)
36%
-9% worse vs. Amoxil (amoxicillin)
24%
-10% worse vs. Amoxil (amoxicillin)
112 reviews
Have you used Vibramycin (doxycycline)?
Worth itNot sureNot worth it
Side effects
amoxicillinDoxycycline

The amoxicillin FDA package insert doesn’t have numbers about how common side effects are.

More about amoxicillin side effects »
  • Any adverse event 40%
  • Nausea 13%
  • Vomiting 8%
  • Diarrhea 3%
  • Bacterial vaginitis 3%
  • Headache 2%
  • Upper abdominal pain 2%
  • Vaginal yeast infection 2%
More Doxycycline side effects »
How it works
amoxicillinDoxycycline
Amoxil (amoxicillin) is an antibiotic. It kills bacteria, and prevents them from reproducing and making their own protective covering.Vibramycin (Doxycycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.
Type of medication
amoxicillinDoxycycline
Prescription only
Prescription only
Available as
amoxicillinDoxycycline
  • Pill
  • Chewable tablet
  • Extended-release tablet
  • Liquid
  • Pill
  • Delayed release capsule
  • Liquid
Used for
amoxicillinDoxycycline
Risk factors for serious side effects
amoxicillinDoxycycline
  • Taking Amoxil (amoxicillin) for a long time
  • Weakened immune system
  • Not taking Amoxil (amoxicillin) correctly
  • History of penicillin allergies
  • Using oral birth control pills
Detailed Amoxil (amoxicillin) risks & warnings »
  • Age 8 years or younger
  • Using oral birth control pills
  • Long antibiotic treatment period
  • Women of childbearing age
Detailed Vibramycin (doxycycline) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
amoxicillinDoxycycline
  • Take with food to prevent upset stomach. If you're taking the extended-release version, take within 1 hour of finishing your meal.
No food related info.
Upsides and benefits
amoxicillinDoxycycline
  • First choice medicine to treat many bacterial infections.
  • Available in generic.
  • Available in different forms: tablet, capsule, and liquid. The liquid comes in many different flavors to make it taste better for people who don't like pills.
  • Side effects are generally not too bad compared to other antibiotics.
  • Available in generic.
  • Available in different forms: tablet, capsule, and suspension.
  • Used to treat many types of bacterial infections.
  • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
Downsides and risks
amoxicillinDoxycycline
  • While Amoxil (amoxicillin) can be used to treat different bacterial infections, many don't respond to it.
  • Can cause diarrhea, nausea, and vomiting.
  • Except for the extended-release form, you have to take Amoxil (amoxicillin) 2 to 3 times a day, which can be hard to remember.
  • The extended-release form can be more expensive because it's a brand name.
  • Can't be used in pregnant women and children under 8 years old.
  • Makes your skin more sensitive to the sun.
  • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
  • Can make birth control less effective.
  • Can cause diarrhea.
Tips from our pharmacists for people taking the medication
amoxicillinDoxycycline
  • Finish all of the medicine, even if you start to feel better. Stopping Amoxil (amoxicillin) early can make the infection come back and harder to treat.
  • If you're on birth control, Amoxil (amoxicillin) might make it less effective. Talk to your doctor to see if you need to use backup.
  • Take with food to prevent upset stomach. If you're taking the extended-release version, take within 1 hour of finishing your meal.
  • If you have the liquid, keep the bottle in the fridge. The bottle is only good for 14 days after you pick it up. Shake the bottle well before using each dose.
  • You may have diarrhea or stomach upset when taking Amoxil (amoxicillin), but it should get better soon after you've finished. If the diarrhea gets worse, tell your doctor
  • Take the medication exactly how your doctor tells you to.
  • If you're using birth control pills, this medication can make them less effective.
  • Wear sunblock if you have to go out into the sun since your skin can become more sensitive to sunburn.
  • Can cause diarrhea, nausea or vomiting.
  • Space out any vitamins by at least two hours.
  • Take with plenty of food and liquids.
  • Don't take any medications with bismuth (Pepto-Bismol, Kaopectate) while taking this medication.
  • Don't lie down for at least 30 minutes after taking this medication.
Learn more
More about amoxicillinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Amoxil (amoxicillin)?
Worth itNot sureNot worth it
More about DoxycyclineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Vibramycin (doxycycline)?
Worth itNot sureNot worth it