Compare amoxicillin vs. Erygel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Amoxil
(amoxicillin)

Akne-Mycin
(erythromycin)

Treats bacterial infections. Amoxil (amoxicillin) is a good and cheap antibiotic that comes in different forms to treat many types of bacterial infections.Topical treatment for acne. Akne-Mycin (Erythromycin) is a very common acne treatment you apply to the skin that may work better when combined with other topical medicines.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for amoxicillin
Best available price for 30 (500mg) capsules of amoxicillin
Coupons for Erygel
Best available price for 1 (30g of 2%) tube of gel of erythromycin
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5amoxicillin
Reviews for Amoxil (amoxicillin)
62%
of people (All ages) say Amoxil (amoxicillin) is worth it
45%
say it works well
14%
say it's a big hassle
786 reviews
Have you used Amoxil (amoxicillin)?
Worth itNot sureNot worth it
Reviews for Akne-Mycin (erythromycin)
46%
-16% worse vs. Amoxil (amoxicillin)
34%
-11% worse vs. Amoxil (amoxicillin)
19%
-5% worse vs. Amoxil (amoxicillin)
Have you used Akne-Mycin (erythromycin)?
Worth itNot sureNot worth it
Side effects
amoxicillinErygel

The amoxicillin FDA package insert doesn’t have numbers about how common side effects are.

More about amoxicillin side effects »
  • Burning 25%
More Erygel side effects »
How it works
amoxicillinErygel
Amoxil (amoxicillin) is an antibiotic. It kills bacteria, and prevents them from reproducing and making their own protective covering.Akne-Mycin (Erythromycin) is a topical antibiotic. It fights bacteria that cause acne in oil (sebaceous) glands, and contains alcohol which dries out acne-affected areas.
Type of medication
amoxicillinErygel
Prescription only
Prescription only
Available as
amoxicillinErygel
  • Pill
  • Chewable tablet
  • Extended-release tablet
  • Liquid
  • Cream, gel, or ointment
  • Topical solution
Used for
amoxicillinErygel
Risk factors for serious side effects
amoxicillinErygel
  • Taking Amoxil (amoxicillin) for a long time
  • Weakened immune system
  • Not taking Amoxil (amoxicillin) correctly
  • History of penicillin allergies
  • Using oral birth control pills
Detailed Amoxil (amoxicillin) risks & warnings »
  • Using other medicines or products that irritate the skin
  • Eczema
  • Extreme temperatures (hot or cold)
Detailed Akne-Mycin (erythromycin) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Food
amoxicillinErygel
  • Take with food to prevent upset stomach. If you're taking the extended-release version, take within 1 hour of finishing your meal.
No food related info.
Pain
amoxicillinErygel
No pain related info.
  • Let your doctor know if you notice abdominal discomfort, pain or diarrhea after starting this medicine.
Weight
amoxicillinErygel
No weight related info.
  • Better choice if you're pregnant. erythromycin is categorized as pregnancy Category B (likely safe) as compared to similar topical medicines that are Category C (weigh risks vs benefits).
Upsides and benefits
amoxicillinErygel
  • First choice medicine to treat many bacterial infections.
  • Available in generic.
  • Available in different forms: tablet, capsule, and liquid. The liquid comes in many different flavors to make it taste better for people who don't like pills.
  • Side effects are generally not too bad compared to other antibiotics.
  • Applying erythromycin to the skin reduces the amount of acne bacteria and "calms" the skin down (lowers the inflammatory response) in acne.
  • Available in a gel formulation which may be better if your skin is very oily.
  • Better choice if you're pregnant. erythromycin is categorized as pregnancy Category B (likely safe) as compared to similar topical medicines that are Category C (weigh risks vs benefits).
Downsides and risks
amoxicillinErygel
  • While Amoxil (amoxicillin) can be used to treat different bacterial infections, many don't respond to it.
  • Can cause diarrhea, nausea, and vomiting.
  • Except for the extended-release form, you have to take Amoxil (amoxicillin) 2 to 3 times a day, which can be hard to remember.
  • The extended-release form can be more expensive because it's a brand name.
  • There's a risk of irritation with anything you apply to your skin and this is no different. erythromycin, like other topical antibiotics, can cause skin irritation and may appear as redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
  • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas
  • Studies show it works better when combined with other topical medicines to fight acne and reduce the risk of it losing its effectiveness over time.
  • Can cause severe inflammation of the large intestine (pseudomembranous colitis)
  • Stop using if you don't notice any improvement in your acne after 6-8 weeks. The most time you can use it is three months.
Tips from our pharmacists for people taking the medication
amoxicillinErygel
  • Finish all of the medicine, even if you start to feel better. Stopping Amoxil (amoxicillin) early can make the infection come back and harder to treat.
  • If you're on birth control, Amoxil (amoxicillin) might make it less effective. Talk to your doctor to see if you need to use backup.
  • Take with food to prevent upset stomach. If you're taking the extended-release version, take within 1 hour of finishing your meal.
  • If you have the liquid, keep the bottle in the fridge. The bottle is only good for 14 days after you pick it up. Shake the bottle well before using each dose.
  • You may have diarrhea or stomach upset when taking Amoxil (amoxicillin), but it should get better soon after you've finished. If the diarrhea gets worse, tell your doctor
  • Very commonly used topical antibiotic to treat acne.
  • The only topical erythromycin in a gel formula.
  • Apply a thin film to clean and dry affected skin once or twice a day.
  • It may take 6-8 weeks before you see improvement in your acne.
  • Avoid getting into your eyes, nose or mouth.
  • Let your doctor know if you notice abdominal discomfort, pain or diarrhea after starting this medicine.
  • Using a moisturizer that doesn't block your pores (non-comedogenic) may help lessen common side effects of skin dryness and peeling.
  • Taking good care of your skin is an important part of treating acne. Lightly wash with warm water and non-soap-based or gentle cleanser.
Learn more
More about amoxicillinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Amoxil (amoxicillin)?
Worth itNot sureNot worth it
More about ErygelSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Akne-Mycin (erythromycin)?
Worth itNot sureNot worth it