Compare Amoxicillin vs. Erygel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Amoxil
(Amoxicillin)

Akne-Mycin
(Erythromycin)

Treats bacterial infections. Amoxil (Amoxicillin) is a good and cheap antibiotic to treat many types of bacterial infections. However, many bacteria are resistant to this medication.Topical treatment for acne. Akne-Mycin (Erythromycin) is a very common acne treatment you apply to the skin that may work better when combined with other topical medicines.
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Reviews & ratings
Filter group. All currently selected
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5.0025641025641026Amoxicillin
Reviews for Amoxil (Amoxicillin)
62%
of people (All ages) say Amoxil (Amoxicillin) is worth it
45%
say it works well
14%
say it's a big hassle
780 reviews
Have you used Amoxil (Amoxicillin)?
Worth itNot sureNot worth it
Reviews for Akne-Mycin (Erythromycin)
46%
16% vs. Amoxil (Amoxicillin)
34%
11% vs. Amoxil (Amoxicillin)
20%
6% vs. Amoxil (Amoxicillin)
Have you used Akne-Mycin (Erythromycin)?
Worth itNot sureNot worth it
Side effects
AmoxicillinErygel

The Amoxicillin FDA package insert doesn’t have numbers about how common side effects are.

More about Amoxicillin side effects »

The Erygel FDA package insert doesn’t have numbers about how common side effects are.

More about Erygel side effects »
How it works
AmoxicillinErygel
Amoxil (Amoxicillin) is an antibiotic. It kills bacteria and prevents them from reproducing and making their own protective covering.Akne-Mycin (Erythromycin) is a topical antibiotic. It fights bacteria that cause acne in oil (sebaceous) glands, and contains alcohol which dries out acne-affected areas.
Type of medication
AmoxicillinErygel
Antibiotic
Penicillin
Prescription only
Acne agent
Antibiotic
Prescription only
Available as
AmoxicillinErygel
  • Pill
  • Chewable tablet
  • Liquid
  • Cream, gel, or ointment
  • Topical solution
Used for (click to learn more)
AmoxicillinErygel
Risk factors for serious side effects
AmoxicillinErygel
  • Long antibiotic treatment period
  • History of penicillin allergies
  • Using oral birth control pills
    Detailed Amoxil (Amoxicillin) risks & warnings »
      • Using other medicines or products that irritate the skin
      • Eczema
      • Extreme temperatures (hot or cold)
        Detailed Akne-Mycin (Erythromycin) risks & warnings »
        Pregnancy

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Food
        AmoxicillinErygel
        • Take with food to decrease upsetting your stomach (nausea, vomiting).
        No food related info.
        Pain
        AmoxicillinErygel
        No pain related info.
        • Let your doctor know if you notice abdominal discomfort, pain or diarrhea after starting this medicine.
        Weight
        AmoxicillinErygel
        No weight related info.
        • Better choice if you're pregnant. erythromycin is categorized as pregnancy Category B (likely safe) as compared to similar topical medicines that are Category C (weigh risks vs benefits).
        Upsides and benefits
        AmoxicillinErygel
        • Available in generic.
        • Available in different forms: tablet, capsule, and suspension.
        • Used to treat many types of bacterial infections.
        • Applying erythromycin to the skin reduces the amount of acne bacteria and "calms" the skin down (lowers the inflammatory response) in acne.
        • Available in a gel formulation which may be better if your skin is very oily.
        • Better choice if you're pregnant. erythromycin is categorized as pregnancy Category B (likely safe) as compared to similar topical medicines that are Category C (weigh risks vs benefits).
        Downsides and risks
        AmoxicillinErygel
        • Suspension must be stored in the fridge.
        • Can make birth control pills and live vaccines less effective.
        • Many bacteria have developed resistance to this antibiotic.
        • Can cause diarrhea.
        • There's a risk of irritation with anything you apply to your skin and this is no different. erythromycin, like other topical antibiotics, can cause skin irritation and may appear as redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
        • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas
        • Studies show it works better when combined with other topical medicines to fight acne and reduce the risk of it losing its effectiveness over time.
        • Can cause severe inflammation of the large intestine (pseudomembranous colitis)
        • Stop using if you don't notice any improvement in your acne after 6-8 weeks. The most time you can use it is three months.
        Tips from our pharmacists for people taking the medication
        AmoxicillinErygel
        • Finish all of the medicine your doctor gives you, even if you start to feel better. Stopping it early can cause the bacteria to develop resistance, making the medicine ineffective.
        • If you're taking birth control pills, this medication may make them less effective.
        • Take with food to decrease upsetting your stomach (nausea, vomiting).
        • If you're giving the suspension, you can mix it with a cold drink, but make sure to take it right away.
        • Keep the suspension form in the fridge. All other forms should be kept at room temperature.
        • You may have loose stool when taking this medicine, but it should get better soon after finishing the course. If the diarrhea worsens, tell your doctor.
        • Very commonly used topical antibiotic to treat acne.
        • The only topical erythromycin in a gel formula.
        • Apply a thin film to clean and dry affected skin once or twice a day.
        • It may take 6-8 weeks before you see improvement in your acne.
        • Avoid getting into your eyes, nose or mouth.
        • Let your doctor know if you notice abdominal discomfort, pain or diarrhea after starting this medicine.
        • Using a moisturizer that doesn't block your pores (non-comedogenic) may help lessen common side effects of skin dryness and peeling.
        • Taking good care of your skin is an important part of treating acne. Lightly wash with warm water and non-soap-based or gentle cleanser.
        Learn more
        More about AmoxicillinSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Amoxil (Amoxicillin)?
        Worth itNot sureNot worth it
        More about ErygelSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Akne-Mycin (Erythromycin)?
        Worth itNot sureNot worth it