Compare Amoxicillin vs. Erygel

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Treats bacterial infections. Amoxil (Amoxicillin) is a good and cheap antibiotic to treat many types of bacterial infections. However, many bacteria are resistant to this medication.Topical treatment for acne. Akne-Mycin (Erythromycin) is a very common acne treatment you apply to the skin that may work better when combined with other topical medicines.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Amoxil (Amoxicillin)
of people say Amoxil (Amoxicillin) is worth it
say it works well
say it's a big hassle
780 reviews
Reviews for Akne-Mycin (Erythromycin)
16% vs. Amoxil (Amoxicillin)
11% vs. Amoxil (Amoxicillin)
6% vs. Amoxil (Amoxicillin)
Side effects

The Amoxicillin FDA package insert doesn’t have numbers about how common side effects are.

More about Amoxicillin side effects »

The Erygel FDA package insert doesn’t have numbers about how common side effects are.

More about Erygel side effects »
How it works
Amoxil (Amoxicillin) is an antibiotic. It kills bacteria and prevents them from reproducing and making their own protective covering.Akne-Mycin (Erythromycin) is a topical antibiotic. It fights bacteria that cause acne in oil (sebaceous) glands, and contains alcohol which dries out acne-affected areas.
Type of medication
Prescription only
Acne agent
Prescription only
Available as
  • Pill
  • Chewable tablet
  • Liquid
  • Cream, gel, or ointment
  • Topical solution
Used for (click to learn more)
Risk factors for serious side effects
  • Long antibiotic treatment period
  • History of penicillin allergies
  • Using oral birth control pills
    Detailed Amoxil (Amoxicillin) risks & warnings »
      • Using other medicines or products that irritate the skin
      • Eczema
      • Extreme temperatures (hot or cold)
        Detailed Akne-Mycin (Erythromycin) risks & warnings »
        Pregnancy category
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        No specific alcohol-related info.No specific alcohol-related info.
        • Take with food to decrease upsetting your stomach (nausea, vomiting).
        No specific food-related info.
        Kidneys and liver
        No specific kidneys and liver-related info.No specific kidneys and liver-related info.
        No specific sex-related info.No specific sex-related info.
        No specific sleep-related info.No specific sleep-related info.
        No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        • Available in generic.
        • Available in different forms: tablet, capsule, and suspension.
        • Used to treat many types of bacterial infections.
        • Applying erythromycin to the skin reduces the amount of acne bacteria and "calms" the skin down (lowers the inflammatory response) in acne.
        • Available in a gel formulation which may be better if your skin is very oily.
        • Better choice if you're pregnant. erythromycin is categorized as pregnancy Category B (likely safe) as compared to similar topical medicines that are Category C (weigh risks vs benefits).
        Downsides and risks
        • Suspension must be stored in the fridge.
        • Can make birth control pills and live vaccines less effective.
        • Many bacteria have developed resistance to this antibiotic.
        • Can cause diarrhea.
        • There's a risk of irritation with anything you apply to your skin and this is no different. erythromycin, like other topical antibiotics, can cause skin irritation and may appear as redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
        • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas
        • Studies show it works better when combined with other topical medicines to fight acne and reduce the risk of it losing its effectiveness over time.
        • Can cause severe inflammation of the large intestine (pseudomembranous colitis)
        • Stop using if you don't notice any improvement in your acne after 6-8 weeks. The most time you can use it is three months.
        Tips from our pharmacists for people taking the medication
        • Finish all of the medicine your doctor gives you, even if you start to feel better. Stopping it early can cause the bacteria to develop resistance, making the medicine ineffective.
        • If you're taking birth control pills, this medication may make them less effective.
        • Take with food to decrease upsetting your stomach (nausea, vomiting).
        • If you're giving the suspension, you can mix it with a cold drink, but make sure to take it right away.
        • Keep the suspension form in the fridge. All other forms should be kept at room temperature.
        • You may have loose stool when taking this medicine, but it should get better soon after finishing the course. If the diarrhea worsens, tell your doctor.
        • Very commonly used topical antibiotic to treat acne.
        • The only topical erythromycin in a gel formula.
        • Apply a thin film to clean and dry affected skin once or twice a day.
        • It may take 6-8 weeks before you see improvement in your acne.
        • Avoid getting into your eyes, nose or mouth.
        • Let your doctor know if you notice abdominal discomfort, pain or diarrhea after starting this medicine.
        • Using a moisturizer that doesn't block your pores (non-comedogenic) may help lessen common side effects of skin dryness and peeling.
        • Taking good care of your skin is an important part of treating acne. Lightly wash with warm water and non-soap-based or gentle cleanser.
        Learn more
        More about AmoxicillinSide effectsReviews & ratingsAlternativesFDA package insert
        More about ErygelSide effectsReviews & ratingsAlternativesFDA package insert