Compare Amoxicillin vs. Levaquin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Amoxil
(Amoxicillin)

Levaquin
(Levofloxacin)

Treats bacterial infections. Amoxil (Amoxicillin) is a good and cheap antibiotic to treat many types of bacterial infections. However, many bacteria are resistant to this medication.Kills bacteria. Levaquin (Levofloxacin) is good for treating many bacterial infections and is available as generic. However, it can cause damage to your tendons, and make your skin more sensitive to the sun.
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Reviews & ratings
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Button Group. All currently active
5.0025641025641026Amoxicillin
Reviews for Amoxil (Amoxicillin)
62%
of people say Amoxil (Amoxicillin) is worth it
45%
say it works well
14%
say it's a big hassle
Reviews for Levaquin (Levofloxacin)
54%
8% vs. Amoxil (Amoxicillin)
39%
6% vs. Amoxil (Amoxicillin)
29%
15% vs. Amoxil (Amoxicillin)
Side effects
AmoxicillinLevaquin

The Amoxicillin FDA package insert doesn’t have numbers about how common side effects are.

More about Amoxicillin side effects »

The Levaquin FDA package insert doesn’t have numbers about how common side effects are.

More about Levaquin side effects »
How it works
AmoxicillinLevaquin
Amoxil (Amoxicillin) is an antibiotic. It kills bacteria and prevents them from reproducing and making their own protective covering.Levaquin (Levofloxacin) is an antibiotic. It kills bacteria by preventing them from reproducing and repairing themselves.
Type of medication
AmoxicillinLevaquin
Antibiotic
Penicillin
Prescription only
Antibiotic
Fluoroquinolone
Prescription only
Available as
AmoxicillinLevaquin
  • Pill
  • Chewable tablet
  • Liquid
  • Pill
  • Liquid
Used for (click to learn more)
AmoxicillinLevaquin
Risk factors for serious side effects
AmoxicillinLevaquin
  • Long antibiotic treatment period
  • History of penicillin allergies
  • Using oral birth control pills
    Detailed Amoxil (Amoxicillin) risks & warnings »
    • Over 60 years of age
    • On long-term steroid use
    • Heart, kidney, or lung transplant
      • History of liver disease
      • Seizures
          • Diabetes
          • Taking medications for diabetes
              Detailed Levaquin (Levofloxacin) risks & warnings »
              Pregnancy category
              AmoxicillinLevaquin
              BFDA pregnancy category (Probably safe)

              Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

              See the FDA package insert
              CFDA pregnancy category (Weigh risks vs. benefits)

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              See the FDA package insert
              Alcohol
              No specific alcohol-related info.No specific alcohol-related info.
              Food
              • Take with food to decrease upsetting your stomach (nausea, vomiting).
              No specific food-related info.
              Kidneys and liver
              No specific kidneys and liver-related info.No specific kidneys and liver-related info.
              Sex
              No specific sex-related info.No specific sex-related info.
              Sleep
              No specific sleep-related info.No specific sleep-related info.
              Weight
              No specific weight-related info.No specific weight-related info.
              Upsides and benefits
              AmoxicillinLevaquin
              • Available in generic.
              • Available in different forms: tablet, capsule, and suspension.
              • Used to treat many types of bacterial infections.
              • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
              • Available in generic.
              • Available in different forms: tablet, capsule, and suspension.
              • Used to treat many types of bacterial infections.
              Downsides and risks
              AmoxicillinLevaquin
              • Suspension must be stored in the fridge.
              • Can make birth control pills and live vaccines less effective.
              • Many bacteria have developed resistance to this antibiotic.
              • Can cause diarrhea.
              • Must be used with caution in people over 60 years of age, or who have had either an organ transplant or on long-term steroid use due to possible tendon rupture.
              • Levofloxacin can make your skin more sensitive to the sun.
              • Can't be used if you've ever had myasthenia gravis.
              • You have to space out any medications with aluminum, magnesium or zinc by at least 2 hours.
              • Can cause changes in taste, headaches, and insomnia.
              Tips from our pharmacists for people taking the medication
              AmoxicillinLevaquin
              • Finish all of the medicine your doctor gives you, even if you start to feel better. Stopping it early can cause the bacteria to develop resistance, making the medicine ineffective.
              • If you're taking birth control pills, this medication may make them less effective.
              • Take with food to decrease upsetting your stomach (nausea, vomiting).
              • If you're giving the suspension, you can mix it with a cold drink, but make sure to take it right away.
              • Keep the suspension form in the fridge. All other forms should be kept at room temperature.
              • You may have loose stool when taking this medicine, but it should get better soon after finishing the course. If the diarrhea worsens, tell your doctor.
              • If you notice pain in your Achilles tendons, contact your doctor.
              • Wear sunscreen if you're going to be out in the sun.
              • Take the medication exactly how the doctor tells you to.
              • Take this medication with plenty of fluids.
              • Space out any medications containing aluminum, magnesium or zinc by at least 2 hours.
              • Can cause diarrhea, nausea or vomiting.
              • Can cause changes in taste, headaches and insomnia.
              Learn more
              More about AmoxicillinSide effectsReviews & ratingsAlternativesFDA package insert
              More about LevaquinSide effectsReviews & ratingsAlternativesFDA package insert