Compare Amoxicillin vs. Minocycline

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Treats bacterial infections. Amoxil (Amoxicillin) is a good and cheap antibiotic to treat many types of bacterial infections. However, many bacteria are resistant to this medication.Treats bacterial infections. Solodyn (Minocycline) is an effective way to treat certain skin infections, acne, and rosacea, but you'll need to use barrier methods of birth control since it can make birth control pills less effective and cause birth defects.
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Reviews & ratings
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Reviews for Amoxil (Amoxicillin)
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Side effects

The Amoxicillin FDA package insert doesn’t have numbers about how common side effects are.

More about Amoxicillin side effects »

We haven’t found good data for Minocycline side effects.

FDA side effect reports for Minocycline »
How it works
Amoxil (Amoxicillin) is an antibiotic. It kills bacteria and prevents them from reproducing and making their own protective covering.Solodyn (Minocycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.
Type of medication
Prescription only
Prescription only
Available as
  • Pill
  • Chewable tablet
  • Liquid
  • Pill
  • Extended release
  • Extended release capsule
Used for (click to learn more)
Risk factors for serious side effects
  • Long antibiotic treatment period
  • History of penicillin allergies
  • Using oral birth control pills
    Detailed Amoxil (Amoxicillin) risks & warnings »
    • Age 8 years or younger
    • Using oral birth control pills
    • Long antibiotic treatment period
        • Women of childbearing age
        Detailed Solodyn (Minocycline) risks & warnings »
        Pregnancy category
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        DFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        No specific alcohol-related info.No specific alcohol-related info.
        • Take with food to decrease upsetting your stomach (nausea, vomiting).
        No specific food-related info.
        Kidneys and liver
        No specific kidneys and liver-related info.No specific kidneys and liver-related info.
        No specific sex-related info.No specific sex-related info.
        No specific sleep-related info.No specific sleep-related info.
        No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        • Available in generic.
        • Available in different forms: tablet, capsule, and suspension.
        • Used to treat many types of bacterial infections.
        • Clinical studies show it's effective against MRSA, a common skin infection, and it's commonly used to treat acne and rosacea.
        • Available as a generic, so it should be reasonably priced.
        • Solodyn (Minocycline) is less likely to cause sunburn than other tetracycline antibiotics.
        • Bacteria are less likely to become resistant to Solodyn (Minocycline) than other tetracycline antibiotics.
        Downsides and risks
        • Suspension must be stored in the fridge.
        • Can make birth control pills and live vaccines less effective.
        • Many bacteria have developed resistance to this antibiotic.
        • Can cause diarrhea.
        • It can make birth control pills less effective, so people should use barrier methods of birth control like condoms or diaphragms while on Solodyn (Minocycline).
        • Can stain your teeth, mouth, and gums if you're using the tablets, or your skin if you're using the topical version, but this is temporary.
        Tips from our pharmacists for people taking the medication
        • Finish all of the medicine your doctor gives you, even if you start to feel better. Stopping it early can cause the bacteria to develop resistance, making the medicine ineffective.
        • If you're taking birth control pills, this medication may make them less effective.
        • Take with food to decrease upsetting your stomach (nausea, vomiting).
        • If you're giving the suspension, you can mix it with a cold drink, but make sure to take it right away.
        • Keep the suspension form in the fridge. All other forms should be kept at room temperature.
        • You may have loose stool when taking this medicine, but it should get better soon after finishing the course. If the diarrhea worsens, tell your doctor.
        • Both men and women should use barrier methods of birth control while on Solodyn (Minocycline) since it can cause birth defects and make birth control pills less effective.
        • Can make you dizzy, so be careful if you're getting up from lying down or sitting. Don't drive until you know how it affects you.
        • Can stain your teeth, tongue and gums, but this is temporary.
        • Take this exactly how your doctor or pharmacist tells you until it's all gone.
        • Don't eat any dairy products or take any vitamins within 2 hours of taking Solodyn (Minocycline) because they can make the medication less effective.
        Learn more
        More about AmoxicillinSide effectsReviews & ratingsAlternativesFDA package insert
        More about MinocyclineSide effectsReviews & ratingsAlternativesFDA package insert