Compare amoxicillin vs. Minocycline

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Amoxil
(amoxicillin)

Solodyn
(minocycline)

Treats bacterial infections. Amoxil (amoxicillin) is a good and cheap antibiotic that comes in different forms to treat many types of bacterial infections.Treats bacterial infections. Solodyn (Minocycline) is an effective way to treat certain skin infections, acne, and rosacea, but you'll need to use barrier methods of birth control since it can make birth control pills less effective and cause birth defects.
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Coupons for amoxicillin
Best available price for 30 (500mg) capsules of amoxicillin
Coupons for Minocycline
Best available price for 60 (100mg) tablets of minocycline
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5amoxicillin
Reviews for amoxicillin
62%
of people (All ages) say amoxicillin is worth it
45%
say it works well
14%
say it's a big hassle
786 reviews
Have you used Amoxil (amoxicillin)?
Worth itNot sureNot worth it
Reviews for Minocycline
53%
+9% better vs. amoxicillin
59%
-14% worse vs. amoxicillin
18%
+4% better vs. amoxicillin
Have you used Solodyn (minocycline)?
Worth itNot sureNot worth it
Side effects
amoxicillinMinocycline

The amoxicillin FDA package insert doesn’t have numbers about how common side effects are.

More about amoxicillin side effects »

We haven’t found good data for Minocycline side effects.

FDA side effect reports for Minocycline »
How it works
amoxicillinMinocycline
Amoxil (amoxicillin) is an antibiotic. It kills bacteria, and prevents them from reproducing and making their own protective covering.Solodyn (Minocycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.
Type of medication
amoxicillinMinocycline
Prescription onlyPrescription only
Available as
amoxicillinMinocycline
  • Pill
  • Chewable tablet
  • Extended-release tablet
  • Liquid
  • Pill
  • Extended release
  • Extended release capsule
Used for
amoxicillinMinocycline
Risk factors for serious side effects
amoxicillinMinocycline
  • Taking Amoxil (amoxicillin) for a long time
  • Weakened immune system
  • Not taking Amoxil (amoxicillin) correctly
  • History of penicillin allergies
  • Using oral birth control pills
Detailed Amoxil (amoxicillin) risks & warnings »
  • Age 8 years or younger
  • Using oral birth control pills
  • Long antibiotic treatment period
  • Women of childbearing age
Detailed Solodyn (minocycline) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Price
amoxicillinMinocycline
No price related info.
  • Available as a generic, so it should be reasonably priced.
Food
amoxicillinMinocycline
  • Take with food to prevent upset stomach. If you're taking the extended-release version, take within 1 hour of finishing your meal.
No food related info.
Upsides and benefits
amoxicillinMinocycline
  • First choice medicine to treat many bacterial infections.
  • Available in generic.
  • Available in different forms: tablet, capsule, and liquid. The liquid comes in many different flavors to make it taste better for people who don't like pills.
  • Side effects are generally not too bad compared to other antibiotics.
  • Clinical studies show it's effective against MRSA, a common skin infection, and it's commonly used to treat acne and rosacea.
  • Available as a generic, so it should be reasonably priced.
  • Solodyn (Minocycline) is less likely to cause sunburn than other tetracycline antibiotics.
  • Bacteria are less likely to become resistant to Solodyn (Minocycline) than other tetracycline antibiotics.
Downsides and risks
amoxicillinMinocycline
  • While Amoxil (amoxicillin) can be used to treat different bacterial infections, many don't respond to it.
  • Can cause diarrhea, nausea, and vomiting.
  • Except for the extended-release form, you have to take Amoxil (amoxicillin) 2 to 3 times a day, which can be hard to remember.
  • The extended-release form can be more expensive because it's a brand name.
  • It can make birth control pills less effective, so people should use barrier methods of birth control like condoms or diaphragms while on Solodyn (Minocycline).
  • Can stain your teeth, mouth, and gums if you're using the tablets, or your skin if you're using the topical version, but this is temporary.
Tips from our pharmacists for people taking the medication
amoxicillinMinocycline
  • Finish all of the medicine, even if you start to feel better. Stopping Amoxil (amoxicillin) early can make the infection come back and harder to treat.
  • If you're on birth control, Amoxil (amoxicillin) might make it less effective. Talk to your doctor to see if you need to use backup.
  • Take with food to prevent upset stomach. If you're taking the extended-release version, take within 1 hour of finishing your meal.
  • If you have the liquid, keep the bottle in the fridge. The bottle is only good for 14 days after you pick it up. Shake the bottle well before using each dose.
  • You may have diarrhea or stomach upset when taking Amoxil (amoxicillin), but it should get better soon after you've finished. If the diarrhea gets worse, tell your doctor
  • Both men and women should use barrier methods of birth control while on Solodyn (Minocycline) since it can cause birth defects and make birth control pills less effective.
  • Can make you dizzy, so be careful if you're getting up from lying down or sitting. Don't drive until you know how it affects you.
  • Can stain your teeth, tongue and gums, but this is temporary.
  • Take this exactly how your doctor or pharmacist tells you until it's all gone.
  • Don't eat any dairy products or take any vitamins within 2 hours of taking Solodyn (Minocycline) because they can make the medication less effective.
Learn more
More about amoxicillinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Amoxil (amoxicillin)?
Worth itNot sureNot worth it
More about MinocyclineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Solodyn (minocycline)?
Worth itNot sureNot worth it