Compare amoxicillin vs. Penicillin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Amoxil (amoxicillin)

Prescription only
Treats bacterial infections.

Amoxil (amoxicillin) is a good and cheap antibiotic that comes in different forms to treat many types of bacterial infections.

5.0/ 7 average rating with 786 reviewsforamoxicillin
Kills bacteria.

Penicillin Vk (Penicillin) is good for treating many bacterial infections and is available as a generic. You may need to use another form of birth control along with your birth control pills. It's also best taken on an empty stomach but it can cause an upset stomach.

5.3/ 7 average rating with 1297 reviewsforPenicillin
Upsides
  • First choice medicine to treat many bacterial infections.
  • Available in generic.
  • Available in different forms: tablet, capsule, and liquid. The liquid comes in many different flavors to make it taste better for people who don't like pills.
  • Side effects are generally not too bad compared to other antibiotics.
  • Available in generic.
  • Available in different forms: tablet, capsule and suspension.
  • Used to treat many types of bacterial infections.
Downsides
  • While Amoxil (amoxicillin) can be used to treat different bacterial infections, many don't respond to it.
  • Can cause diarrhea, nausea, and vomiting.
  • Except for the extended-release form, you have to take Amoxil (amoxicillin) 2 to 3 times a day, which can be hard to remember.
  • The extended-release form can be more expensive because it's a brand name.
  • Many bacteria have developed resistance. Your doctor may run tests to see if Penicillin will work on your infection.
  • Can make birth control pills less effective.
  • Best taken on an empty stomach, but can cause stomach upset and diarrhea.
Used for
Dosage forms
  • Pill
  • Chewable tablet
  • Extended-release tablet
  • Liquid
  • Pill
Price
Lowest price near you
$4
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Reviews
786 
62%
think this treatment is worth it
45%
think this treatment works well
14%
think this treatment is a hassle

Have you used Amoxil (amoxicillin)?

Leave a review
1297 
71%
think this treatment is worth it
52%
think this treatment works well
12%
think this treatment is a hassle

Have you used Penicillin Vk (Penicillin)?

Leave a review
Side effects
The Amoxil (amoxicillin) FDA package insert doesn’t have numbers about how common side effects are.
The Penicillin Vk (Penicillin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Interaction with birth control

    Using oral birth control pills

  • Severe diarrhea

    Taking Amoxil (amoxicillin) for a long time

  • Severe allergic reaction

    History of penicillin allergies

  • New infections while taking Amoxil (amoxicillin)

    Weakened immune system

    ...and 1 more risk factors

  • Rash

    Mononucleosis

See more detailed risks and warnings
  • Allergic reactions

    Prior severe allergic reaction to Penicillin Vk (Penicillin)

See more detailed risks and warnings