Compare Anafranil vs. Doxepin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Anafranil (Clomipramine)

Prescription only

Zonalon (Doxepin)

Prescription only
Helps with your actions.

Anafranil (Clomipramine) is helpful in treating OCD, but it can have a lot of side effects.

Helps you stop itching.

Zonalon (Doxepin) works well treating itchy skin, but could make you sleepy.

Upsides
  • Works well to decrease the symptoms of obsessive-compulsive disorder (OCD).
  • Helps some people see improvements in their mood.
  • Can help you sleep.
  • Lower risk of causing heart problems compared to other medicine in this class.
  • In clinical trials, Zonalon (Doxepin) was found to be the most effective cream for treating itchy skin.
  • You can use Zonalon (Doxepin) for up to 8 days at a time.
Downsides
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
  • Can cause sexual performance problems in men.
  • Increases the risk of falls, especially when used in the elderly.
  • You need a prescription for Zonalon (Doxepin).
  • It isn't available as a generic, so it could be kind of pricey.
  • Zonalon (Doxepin) can make you sleepy.
  • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
Used for
  • Skin intching (moderate)
Dosage forms
  • Pill
  • Cream, gel, or ointment
Price
Lowest price near you
$176.64
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Lowest price near you
$9.99
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Reviews
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Side effects
8possible side effects
  • Dry mouth
    84%
  • Somnolence
    54%
  • Tremor
    54%
  • Dizziness
    54%
  • Headache
    52%
  • Constipation
    47%
  • Ejaculation failure
    42%
  • Fatigue
    39%
See more detailed side effects
The Zonalon (Doxepin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Serotonin syndrome

    Using other medications that affect serotonin

  • Seizure

    History of seizure

    ...and 2 more risk factors

  • Withdrawal

    Stopping Anafranil (Clomipramine) suddenly

  • Low blood pressure

    Age 65 years or older

  • Heart problems

    History of heart disease

    ...and 2 more risk factors

See more detailed risks and warnings