Compare Anafranil vs. Doxepin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Anafranil
(clomipramine)

Zonalon
(doxepin)

Helps with your actions. Anafranil (Clomipramine) is helpful in treating OCD, but it can have a lot of side effects.Helps you stop itching. Zonalon (Doxepin) works well treating itchy skin, but could make you sleepy.
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Coupons for Anafranil
Best available price for 60 (50mg) capsules of clomipramine
Coupons for Doxepin
Best available price for 30 (10mg) capsules of doxepin
Reviews & ratings
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Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Anafranil (clomipramine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Zonalon (doxepin)?
Worth itNot sureNot worth it
Side effects
AnafranilDoxepin
  • Dry mouth 67%
  • Tremor 52%
  • Dizziness 40%
  • Drowsiness 38%
  • Headache 11%
  • Constipation 36%
  • Ejaculation failure 40%
  • Fatigue 21%
More Anafranil side effects »

We haven’t found good data for Doxepin side effects.

FDA side effect reports for Doxepin »
How it works
AnafranilDoxepin
Anafranil (Clomipramine) is a tricyclic antidepressant (TCA). It treats obsessive-compulsive disorder by affecting the levels of serotonin and norepinephrine in your brain.Zonalon (Doxepin) is an cream that stops you from itching by blocking the chemical receptors that cause itching.
Type of medication
AnafranilDoxepin
Prescription onlyPrescription only
Available as
AnafranilDoxepin
  • Pill
  • Cream, gel, or ointment
Used for
AnafranilDoxepin
  • Skin Intching Moderate
Risk factors for serious side effects
AnafranilDoxepin
  • Age 24 years or younger
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Using other medications that affect serotonin
  • History of seizure
Detailed Anafranil (clomipramine) risks & warnings »
    Detailed Zonalon (doxepin) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Price
    AnafranilDoxepin
    No price related info.
    • It isn't available as a generic, so it could be kind of pricey.
    Interactions
    AnafranilDoxepin
    No interactions related info.
    • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
    Food
    AnafranilDoxepin
    • Take it with food and/or at bedtime to decrease the potential side effects.
    No food related info.
    Sleep
    AnafranilDoxepin
    • Can help you sleep.
    • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
    • Zonalon (Doxepin) can make you sleepy.
    Upsides and benefits
    AnafranilDoxepin
    • Works well to decrease the symptoms of obsessive-compulsive disorder (OCD).
    • Helps some people see improvements in their mood.
    • Can help you sleep.
    • Lower risk of causing heart problems compared to other medicine in this class.
    • In clinical trials, Zonalon (Doxepin) was found to be the most effective cream for treating itchy skin.
    • You can use Zonalon (Doxepin) for up to 8 days at a time.
    Downsides and risks
    AnafranilDoxepin
    • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
    • Can cause sexual performance problems in men.
    • Increases the risk of falls, especially when used in the elderly.
    • You need a prescription for Zonalon (Doxepin).
    • It isn't available as a generic, so it could be kind of pricey.
    • Zonalon (Doxepin) can make you sleepy.
    • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
    Tips from our pharmacists for people taking the medication
    AnafranilDoxepin
    • Needs to be taken every day for 2 to 3 weeks to see the full effect of the medication.
    • It's important to keep taking Anafranil (Clomipramine) even when you feel your symptoms are getting better.
    • Take it with food and/or at bedtime to decrease the potential side effects.
    • Tell your doctor if you notice sudden mood changes or unusual thoughts.
    • If you decide to stop taking Anafranil (Clomipramine), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
    • Be sure the affected area is clean and dry before applying Zonalon (Doxepin).
    • Wash your hands before and after using it.
    • Apply a thin layer of Zonalon (Doxepin) onto the affected area and rub it in gently.
    • Don’t put a bandage, dressing, or make-up over Zonalon (Doxepin) once it's on your skin.
    • It shouldn't affect you too much, but avoid activities that need you to be fully alert (like driving) until you know how it works.
    Learn more
    More about AnafranilSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Anafranil (clomipramine)?
    Worth itNot sureNot worth it
    More about DoxepinSide effectsFDA package insert
    Have you used Zonalon (doxepin)?
    Worth itNot sureNot worth it