Compare Anafranil vs. Norpramin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Anafranil
(Clomipramine)

Norpramin
(Desipramine)

Helps with your actions. Anafranil (Clomipramine) is helpful in treating OCD, but it can have a lot of side effects.Coming soon.
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Reviews & ratings
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Side effects
AnafranilNorpramin
  • Dry mouth 67%
  • Tremor 52%
  • Dizziness 40%
  • Ejaculation failure 40%
  • Drowsiness 38%
  • Constipation 36%
  • Increased sweating 26%
  • Fatigue 21%
  • Loss of appetite 20%
  • Nausea 19%
More Anafranil side effects »

We haven’t found good data for Norpramin side effects.

FDA side effect reports for Norpramin »
How it works
AnafranilNorpramin
Anafranil (Clomipramine) is a tricyclic antidepressant (TCA). It treats obsessive-compulsive disorder by affecting the levels of serotonin and norepinephrine in your brain.Coming soon.
Type of medication
AnafranilNorpramin
Antidepressant
Tricyclic antidepressant (TCA)
Prescription only
Coming soon.
Available as
AnafranilNorpramin
  • Pill
  • Pill
Used for (click to learn more)
AnafranilNorpramin
  • Depression
Risk factors for serious side effects
AnafranilNorpramin
  • Age 24 years or younger
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Using other medications that affect serotonin
  • History of seizure
  • Taking other medicines that increase seizure risk
  • Alcoholism
  • Stopping Anafranil (Clomipramine) suddenly
  • Age 65 years or older
  • History of heart disease
  • Older age
  • Electrolyte imbalance
Detailed Anafranil (Clomipramine) risks & warnings »
Coming soon.
Pregnancy category
AnafranilNorpramin
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
Food
  • Take it with food and/or at bedtime to decrease the potential side effects.
No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
  • Can cause sexual performance problems in men.
No specific sex-related info.
Sleep
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
  • Can help you sleep.
  • Stopping Anafranil (Clomipramine) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and dizziness. Withdrawal symptoms usually occur within 3-5 days of stopping the medication, and go away within 1-2 weeks. Work with your doctor to gradually reduce your dose.
No specific sleep-related info.
Weight
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
No specific weight-related info.
Upsides and benefits
AnafranilNorpramin
  • Works well to decrease the symptoms of obsessive-compulsive disorder (OCD).
  • Helps some people see improvements in their mood.
  • Can help you sleep.
  • Lower risk of causing heart problems compared to other medicine in this class.
Coming soon.
Downsides and risks
AnafranilNorpramin
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
  • Can cause sexual performance problems in men.
  • Increases the risk of falls, especially when used in the elderly.
Coming soon.
Tips from our pharmacists for people taking the medication
AnafranilNorpramin
  • Needs to be taken every day for 2 to 3 weeks to see the full effect of the medication.
  • It's important to keep taking Anafranil (Clomipramine) even when you feel your symptoms are getting better.
  • Take it with food and/or at bedtime to decrease the potential side effects.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • If you decide to stop taking Anafranil (Clomipramine), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
Coming soon.
Learn more
More about AnafranilSide effectsReviews & ratingsAlternativesFDA package insert
More about NorpraminSide effectsReviews & ratingsFDA package insert