Compare Anafranil vs. Norpramin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Anafranil
(Clomipramine)

Norpramin
(Desipramine)

Helps with your actions. Anafranil (Clomipramine) is helpful in treating OCD, but it can have a lot of side effects.Coming soon.
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Reviews & ratings
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Have you used Anafranil (Clomipramine)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Norpramin (Desipramine)?
Worth itNot sureNot worth it
Side effects
AnafranilNorpramin
  • Dry mouth 67%
  • Tremor 52%
  • Dizziness 40%
  • Ejaculation failure 40%
  • Drowsiness 38%
  • Constipation 36%
  • Increased sweating 26%
  • Fatigue 21%
  • Loss of appetite 20%
  • Nausea 19%
More Anafranil side effects »

We haven’t found good data for Norpramin side effects.

FDA side effect reports for Norpramin »
How it works
AnafranilNorpramin
Anafranil (Clomipramine) is a tricyclic antidepressant (TCA). It treats obsessive-compulsive disorder by affecting the levels of serotonin and norepinephrine in your brain.Coming soon.
Type of medication
AnafranilNorpramin
Antidepressant
Tricyclic antidepressant (TCA)
Prescription only
Coming soon.
Available as
AnafranilNorpramin
  • Pill
  • Pill
Used for (click to learn more)
AnafranilNorpramin
  • Depression
Risk factors for serious side effects
AnafranilNorpramin
  • Age 24 years or younger
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Using other medications that affect serotonin
  • History of seizure
  • Taking other medicines that increase seizure risk
  • Alcoholism
  • Stopping Anafranil (Clomipramine) suddenly
  • Age 65 years or older
  • History of heart disease
  • Older age
  • Electrolyte imbalance
Detailed Anafranil (Clomipramine) risks & warnings »
Coming soon.
Pregnancy category
AnafranilNorpramin
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
Food
  • Take it with food and/or at bedtime to decrease the potential side effects.
No specific food related info.
Sex
  • Can cause sexual performance problems in men.
No specific sex related info.
Sleep
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
  • Can help you sleep.
  • Stopping Anafranil (Clomipramine) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and dizziness. Withdrawal symptoms usually occur within 3-5 days of stopping the medication, and go away within 1-2 weeks. Work with your doctor to gradually reduce your dose.
No specific sleep related info.
Weight
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
No specific weight related info.
Upsides and benefits
AnafranilNorpramin
  • Works well to decrease the symptoms of obsessive-compulsive disorder (OCD).
  • Helps some people see improvements in their mood.
  • Can help you sleep.
  • Lower risk of causing heart problems compared to other medicine in this class.
Coming soon.
Downsides and risks
AnafranilNorpramin
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
  • Can cause sexual performance problems in men.
  • Increases the risk of falls, especially when used in the elderly.
Coming soon.
Tips from our pharmacists for people taking the medication
AnafranilNorpramin
  • Needs to be taken every day for 2 to 3 weeks to see the full effect of the medication.
  • It's important to keep taking Anafranil (Clomipramine) even when you feel your symptoms are getting better.
  • Take it with food and/or at bedtime to decrease the potential side effects.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • If you decide to stop taking Anafranil (Clomipramine), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
Coming soon.
Learn more
More about AnafranilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Anafranil (Clomipramine)?
Worth itNot sureNot worth it
More about NorpraminSide effectsReviews & ratingsFDA package insert
Have you used Norpramin (Desipramine)?
Worth itNot sureNot worth it