Compare Anafranil vs. Silenor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Anafranil
(clomipramine)

Silenor
(doxepin)

Helps with your actions. Anafranil (Clomipramine) is helpful in treating OCD, but it can have a lot of side effects.Helps you relax, and sleep. Doxepin is a non-addictive way to help people stay asleep, but it comes with a list of side effects.
Reviews & ratings
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Have you used Anafranil (clomipramine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Silenor (doxepin)?
Worth itNot sureNot worth it
Side effects
AnafranilSilenor
  • Dry mouth 67%
  • Tremor 52%
  • Dizziness 40%
  • Somnolence 38%
  • Headache 11%
  • Constipation 36%
  • Ejaculation failure 40%
  • Fatigue 21%
More Anafranil side effects »

We haven’t found good data for Silenor side effects.

FDA side effect reports for Silenor »
How it works
AnafranilSilenor
Anafranil (Clomipramine) is a tricyclic antidepressant (TCA). It treats obsessive-compulsive disorder by affecting the levels of serotonin and norepinephrine in your brain.Doxepin is a tricyclic antidepressant. It keeps norepinephrine and serotonin in your brain longer, helping you relax, and sleep. It also blocks the chemical that causes itch, and wakefulness.
Type of medication
AnafranilSilenor
Prescription only
Available as
AnafranilSilenor
  • Pill
  • Pill
  • Liquid
Used for
AnafranilSilenor
  • Alcoholism Anxiety Depression Anxiety Depression Anxiety Depression Psychoneurotic Personality Disorder Insomnia Pruritus Moderate
Risk factors for serious side effects
AnafranilSilenor
  • Age 24 years or younger
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Using other medications that affect serotonin
  • History of seizure
Detailed Anafranil (clomipramine) risks & warnings »
    Coming soon.
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Interactions
    AnafranilSilenor
    No interactions related info.
    • Doxepin can interact with many different medications, vitamins, and alternative treatments.
    Alcohol
    AnafranilSilenor
    No alcohol related info.
    • Stay away from alcohol while taking Doxepin, because it can slow your brain, and stop your breathing.
    Food
    AnafranilSilenor
    • Take it with food and/or at bedtime to decrease the potential side effects.
    No food related info.
    Sleep
    AnafranilSilenor
    • Can help you sleep.
    • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
    No sleep related info.
    Weight
    AnafranilSilenor
    No weight related info.
    • Doxepin can increase your appetite, leading to weight gain.
    Upsides and benefits
    AnafranilSilenor
    • Works well to decrease the symptoms of obsessive-compulsive disorder (OCD).
    • Helps some people see improvements in their mood.
    • Can help you sleep.
    • Lower risk of causing heart problems compared to other medicine in this class.
    • In a clinical trial Doxepin was able to significantly improve sleep quality.
    • Doxepin helps improve your appetite, energy level, and sense of well-being, which increases your interests.
    • Once your body gets used to Doxepin, most of the side effects go away.
    • Doxepin comes in a generic form, so it is pretty cheap.
    • Doxepin is not addictive.
    Downsides and risks
    AnafranilSilenor
    • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
    • Can cause sexual performance problems in men.
    • Increases the risk of falls, especially when used in the elderly.
    • Some people taking Doxepin walk, drive, eat, and have sex while sleeping. Be sure to tell your doctor if this happens to you.
    • Doxepin can increase your appetite, leading to weight gain.
    • Taking Doxepin can make emptying your bladder difficult.
    • Some people have suicidal thoughts when taking Doxepin.
    • Doxepin can interact with many different medications, vitamins, and alternative treatments.
    Tips from our pharmacists for people taking the medication
    AnafranilSilenor
    • Needs to be taken every day for 2 to 3 weeks to see the full effect of the medication.
    • It's important to keep taking Anafranil (Clomipramine) even when you feel your symptoms are getting better.
    • Take it with food and/or at bedtime to decrease the potential side effects.
    • Tell your doctor if you notice sudden mood changes or unusual thoughts.
    • If you decide to stop taking Anafranil (Clomipramine), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
    • Take Doxepin 30 minutes before bedtime so it starts working when you get in bed.
    • Avoid activities that need you to be fully alert like driving, until you know how Doxepin affects you.
    • Follow up with your doctor so he or she can make sure Doxepin is the right medication for your depression.
    • Stay away from alcohol while taking Doxepin, because it can slow your brain, and stop your breathing.
    • Some people get dry mouth, or constipation when taking Doxepin. Sugar free gum or candy can help the dry mouth, and drinking more fluid can help with constipation.
    • Avoid direct sunlight while taking this medication. When you can’t avoid it, be sure to use sunscreen. It’s also important to put on a long-sleeved shirt, pants, hat, and sunglasses.
    Learn more
    More about AnafranilSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Anafranil (clomipramine)?
    Worth itNot sureNot worth it
    More about SilenorSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Silenor (doxepin)?
    Worth itNot sureNot worth it