Compare Anafranil vs. Surmontil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Anafranil
(Clomipramine)

Surmontil
(trimipramine)

Helps with your actions. Anafranil (Clomipramine) is helpful in treating OCD, but it can have a lot of side effects.Improves your mood. Surmontil (trimipramine) is good at treating depression, but it can cause more side effects, like sleepiness and weight gain, compared to other medicines.
Reviews & ratings
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Have you used Anafranil (Clomipramine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Surmontil (trimipramine)?
Worth itNot sureNot worth it
Side effects
AnafranilSurmontil
  • Depersonalization 2%
  • Emotional lability 2%
  • Dermatitis 2%
  • Dry skin 2%
  • Gastrointestinal disorder 2%
  • Dysphagia 2%
  • Chills 1%
More Anafranil side effects »

The Surmontil FDA package insert doesn’t have numbers about how common side effects are.

More about Surmontil side effects »
How it works
AnafranilSurmontil
Anafranil (Clomipramine) is a tricyclic antidepressant (TCA). It treats obsessive-compulsive disorder by affecting the levels of serotonin and norepinephrine in your brain.Surmontil (trimipramine) is a tricyclic antidepressant. It raises the amount of serotonin and norepinephrine in the brain, 2 chemicals that are known to regulate mood.
Type of medication
AnafranilSurmontil
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic available
Available as
AnafranilSurmontil
  • Pill
  • Pill
Used for
AnafranilSurmontil
Risk factors for serious side effects
AnafranilSurmontil
  • Age 24 years or younger
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Using other medications that affect serotonin
  • History of seizure
Detailed Anafranil (Clomipramine) risks & warnings »
  • People under age 24
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
  • Buspirone
Detailed Surmontil (trimipramine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
AnafranilSurmontil
  • Take it with food and/or at bedtime to decrease the potential side effects.
  • Can be taken with or without food.
Sleep
AnafranilSurmontil
  • Can help you sleep.
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
No sleep related info.
Upsides and benefits
AnafranilSurmontil
  • Works well to decrease the symptoms of obsessive-compulsive disorder (OCD).
  • Helps some people see improvements in their mood.
  • Can help you sleep.
  • Lower risk of causing heart problems compared to other medicine in this class.
  • Surmontil (trimipramine) is part of the first choice medicines to treat depression.
  • Available in generic and in three different strengths.
  • Can be taken once a day, usually before you go to bed.
  • Can be taken with or without food.
Downsides and risks
AnafranilSurmontil
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
  • Can cause sexual performance problems in men.
  • Increases the risk of falls, especially when used in the elderly.
  • You might not notice changes in your mood until you've taken Surmontil (trimipramine) for several weeks.
  • Stopping Surmontil (trimipramine) suddenly without telling your doctor can be dangerous.
  • Surmontil (trimipramine) can cause more side effects than other medicines used to treat depression.
Tips from our pharmacists for people taking the medication
AnafranilSurmontil
  • Needs to be taken every day for 2 to 3 weeks to see the full effect of the medication.
  • It's important to keep taking Anafranil (Clomipramine) even when you feel your symptoms are getting better.
  • Take it with food and/or at bedtime to decrease the potential side effects.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • If you decide to stop taking Anafranil (Clomipramine), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
  • Take Surmontil (trimipramine) at night since it can make you sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • If you forget a dose, take it as soon as you remember, unless it's time for your next dose. Don't take extra medicine to make up for the missed dose.
  • Don't stop taking Surmontil (trimipramine) without talking to your doctor first.
  • Be very careful getting up if you've been sitting or lying down for a while since you can feel dizzy.
Learn more
More about AnafranilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Anafranil (Clomipramine)?
Worth itNot sureNot worth it
More about SurmontilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Surmontil (trimipramine)?
Worth itNot sureNot worth it