Compare Anafranil vs. Vivactil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Anafranil
(clomipramine)

Vivactil
(protriptyline)

Helps with your actions. Anafranil (Clomipramine) is helpful in treating OCD, but it can have a lot of side effects.Improves your mood. Vivactil (protriptyline) is part of the first choice of medicines for depression, but it can cause problems with your heartbeat and change your sex drive.
Reviews & ratings
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Have you used Anafranil (clomipramine)?
Worth itNot sureNot worth it

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Have you used Vivactil (protriptyline)?
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Side effects
AnafranilVivactil
  • Dry mouth 67%
  • Tremor 52%
  • Dizziness 40%
  • Somnolence 38%
  • Headache 11%
  • Constipation 36%
  • Ejaculation failure 40%
  • Fatigue 21%
More Anafranil side effects »

The Vivactil FDA package insert doesn’t have numbers about how common side effects are.

More about Vivactil side effects »
How it works
AnafranilVivactil
Anafranil (Clomipramine) is a tricyclic antidepressant (TCA). It treats obsessive-compulsive disorder by affecting the levels of serotonin and norepinephrine in your brain.Vivactil (protriptyline) is a tricyclic antidepressant. It regulates mood by raising the amount of serotonin and norepinephrine in the brain.
Type of medication
AnafranilVivactil
Prescription onlyPrescription only
Available as
AnafranilVivactil
  • Pill
  • Pill
Used for
AnafranilVivactil
Risk factors for serious side effects
AnafranilVivactil
  • Age 24 years or younger
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Using other medications that affect serotonin
  • History of seizure
Detailed Anafranil (clomipramine) risks & warnings »
  • Under age 24
  • History of heart disease
  • Overactive thyroid
  • History of seizures
  • High blood pressure
Detailed Vivactil (protriptyline) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Food
AnafranilVivactil
  • Take it with food and/or at bedtime to decrease the potential side effects.
No food related info.
Sleep
AnafranilVivactil
  • Can help you sleep.
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
No sleep related info.
Upsides and benefits
AnafranilVivactil
  • Works well to decrease the symptoms of obsessive-compulsive disorder (OCD).
  • Helps some people see improvements in their mood.
  • Can help you sleep.
  • Lower risk of causing heart problems compared to other medicine in this class.
  • Vivactil (protriptyline) is part of the first choice medicines for treating depression.
  • Compared to similar medicines, Vivactil (protriptyline) is less likely to make you feel sleepy.
  • Available in generic.
Downsides and risks
AnafranilVivactil
  • It's more likely to cause side effects like dizziness, drowsiness, weight gain, and constipation compared to other medicines in this class.
  • Can cause sexual performance problems in men.
  • Increases the risk of falls, especially when used in the elderly.
  • Vivactil (protriptyline) can lower your sex drive more than some other similar medicines.
  • Because Vivactil (protriptyline) can cause dizziness, people age 65 and older need to take precautions when taking Vivactil (protriptyline).
  • Vivactil (protriptyline) can worsen heart conditions. If you have a history of heart problems, you may need to have regular testing for your heart.
Tips from our pharmacists for people taking the medication
AnafranilVivactil
  • Needs to be taken every day for 2 to 3 weeks to see the full effect of the medication.
  • It's important to keep taking Anafranil (Clomipramine) even when you feel your symptoms are getting better.
  • Take it with food and/or at bedtime to decrease the potential side effects.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • If you decide to stop taking Anafranil (Clomipramine), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
  • Take Vivactil (protriptyline) at night since it can make you sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • You might have to take Vivactil (protriptyline) for a few weeks before you notice any changes in your mood.
  • Vivactil (protriptyline) can make you more sensitive to the sun. Wear sunscreen or cover your skin if you're going to be out in the sun for a while.
  • Don't stop taking Vivactil (protriptyline) without talking to your doctor first.
  • Be very careful getting up if you've been sitting or lying down for a while since Vivactil (protriptyline) can make you feel dizzy.
Learn more
More about AnafranilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Anafranil (clomipramine)?
Worth itNot sureNot worth it
More about VivactilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Vivactil (protriptyline)?
Worth itNot sureNot worth it