Compare Androderm vs. Axiron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Androderm
(Testosterone Patch)

Axiron
(Testosterone Topical Solution)

Treats low testosterone. The testosterone patch is a topical form of hormone replacement that doesn't affect people you come in contact with, but it can cause skin irritation so you have to rotate its position every night.Treats low testosterone. This testosterone topical solution is a convenient topical form of hormone replacement that's less likely to rub off on other people you come into contact with, but it's not available as a generic yet.
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Reviews & ratings
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Side effects
AndrodermAxiron

The Androderm FDA package insert doesn’t have numbers about how common side effects are.

More about Androderm side effects »

The Axiron FDA package insert doesn’t have numbers about how common side effects are.

More about Axiron side effects »
How it works
AndrodermAxiron
The testosterone patch works by adding or replacing the hormone testosterone in your body. Testosterone is responsible for causing and maintaining many of the changes in male bodies from puberty on.Testosterone topical solution works by adding or replacing the hormone testosterone in your body. Testosterone is responsible for causing and maintaining many of the changes in male bodies from puberty on.
Type of medication
AndrodermAxiron
Hormone replacement
Testosterone
Prescription only
Hormone replacement
Testosterone
Prescription only
Available as
AndrodermAxiron
  • Patch
  • Topical
Used for (click to learn more)
AndrodermAxiron
  • Low testosterone
  • Low testosterone
Risk factors for serious side effects
AndrodermAxiron
Coming soon.Coming soon.
Pregnancy category
AndrodermAxiron
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
  • The testosterone patch doesn't have to be removed when you're having sex or if you're showering or bathing.
No specific sex-related info.
Sleep
No specific sleep-related info.No specific sleep-related info.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
AndrodermAxiron
  • The testosterone patch doesn't have to be removed when you're having sex or if you're showering or bathing.
  • The testosterone patch prevents other people around you from coming in contact with testosterone, unlike other topical forms such as gels.
  • The testosterone patch only has to be placed once each night.
  • You're less likely with this formulation to transfer testosterone topical solution to another person since this is applied to the armpits -- unlike some other forms of topical testosterone.
  • You can use your regular deodorant or antiperspirant, but just make sure to apply that first before using testosterone topical solution.
Downsides and risks
AndrodermAxiron
  • Not available in generic.
  • You have to be careful to rotate the testosterone patch to a different part of your body each night.
  • Can cause skin irritation.
  • Has to be removed before you have an MRI.
  • The patch can become loose if you do heavy exercise or sweat a lot.
  • Only available as brand name.
  • You have to wait at least 2 hours after applying testosterone topical solution before you can swim or bathe, otherwise your body won't absorb the entire amount.
Tips from our pharmacists for people taking the medication
AndrodermAxiron
  • Place the testosterone patch on a clean, dry area of your skin each night. Don't put it on your scrotum or a bony part of your body.
  • Change the area where you place the testosterone patch every night, and wait at least 7 days before you put in on the same site again.
  • Make sure the patch is attached to your skin, especially along the edges. If it loosens, smooth the edges and then the center of the patch with your finger to make sure it's attached completely.
  • If the patch falls off before noon, apply another patch. If it falls off after that, don't apply another patch until your regular time at night. Don't use tape to keep the patch attached.
  • Don't bathe or swim for at least 3 hours after you put a new patch on. Also, heavy exercise or lots of sweating can make your patch fall off.
  • Prime testosterone topical solution first by pumping 3 times before you use a new bottle.
  • If you use deodorant or antiperspirant, apply that first before using testosterone topical solution.
  • Don't swim or bathe for at least 2 hours after you put on testosterone topical solution so that it has time to absorb.
  • Cover the area with clothing as soon as it's dry so you don't spread it to other people.
  • If you think you'll have skin-to-skin contact at the area where you've placed testosterone topical solution, wash that area with soap and water then dry.
  • Don't use testosterone topical solution anywhere besides your armpits.
Learn more
More about AndrodermSide effectsReviews & ratingsAlternativesFDA package insert
More about AxironSide effectsReviews & ratingsAlternativesFDA package insert